Antidepressant-antipsychotic combination doubles likelihood of improvement in psychotic depression
Combination therapy doubles improvement odds in psychotic depression
This meta-analysis of randomized trials found that combination pharmacotherapy (antidepressant-antipsychotic) is associated with a significa…
For psychotic depression, pairing an antidepressant with an antipsychotic more than doubles the chance of improvement compared to other trea…
Serotonergic antidepressants and prolactin-elevating antipsychotics are associated with higher burdens of sexual dysfunction
Certain medications for depression and psychosis can cause sexual issues
This narrative review examines the impact of antidepressants and antipsychotics on sexual dysfunction in patients with depressive and psycho…
Some common treatments for mood and psychotic disorders may impact a patient's sex life, quality of life, and their ability to stay on medic…
Yoga with education yields clinically relevant improvements for depressive symptoms and pain in chronic low back pain
Yoga and Education Show Promise for Back Pain and Depression
This meta-analysis evaluates interventions for individuals with comorbid depressive symptoms and chronic nonspecific low back pain. Yoga wit…
A review of 834 patients suggests that yoga combined with education may improve both chronic back pain and depressive symptoms.
Drug-induced osteoporosis mechanisms and gut microbiota links remain largely unresolved for most medication classes
Many common medicines might change gut bacteria and affect bone strength in older adults
This narrative review examines the association between medications such as glucocorticoids and aromatase inhibitors and gut microbiota alter…
Some drugs like antidepressants and seizure medicines can alter gut bacteria. Scientists are still studying if these changes hurt bones or c…
Maintenance antidepressants show no effect on happy face recognition in adults with recurrent depression
Adults stopping antidepressants did not show worse mood face reading skills after one year of follow up time
This randomized controlled trial in 478 adults with recurrent depression found no evidence that discontinuing maintenance antidepressants al…
People with recurrent depression who stopped taking their medicine did not read happy faces differently than those who kept taking it. Their…
In a cohort of 561 individuals with chronic pain, sex and gender identity influenced repeated prescription refill odds
Your Pain Meds May Depend on Who You Are, Not Just What Hurts
This observational cohort study examined 561 individuals living with chronic pain using public and private prescription claims data over one…
Chronic pain treatment isn’t one-size-fits-all; new research shows your personal identity plays a major role in the prescriptions you receiv…
PETRUSHKA decision-support tool reduced treatment discontinuation and improved symptoms in major depressive disorder
The Algorithm That Helps Doctors Pick the Right Antidepressant for You
This randomized clinical trial evaluated an evidence-based clinical decision-support system called PETRUSHKA against usual care in adults wi…
A new web-based tool helps doctors pick the right antidepressant, cutting discontinuation rates by nearly 40% and helping patients stay on t…
Observational study examines antidepressant use patterns by sex and marital status in US adults
Survey examines antidepressant use among U.S. adults by sex and marital status
An observational study of US adults aged ≥20 years examined antidepressant use patterns by sex and marital status.
A new report looks at how antidepressant use among U.S. adults varies by sex and marital status, offering a snapshot of medication patterns …