Narrative review outlines practical framework for combined lipid and anti-inflammatory therapy in coronary atherosclerosis
Your Heart Has a Hidden Fire
This narrative review examines the role of colchicine and IL-1β inhibitors in patients with coronary atherosclerosis. The authors propose a …
Doctors now know you must fight two enemies at once: the bad fats in your blood and the hidden inflammation that makes them dangerous.
CHIP mutations increase cardiovascular risk and mortality in older adults independent of traditional factors.
Your Aging Blood Cells May Be Quietly Attacking Your Heart
This review synthesizes evidence regarding clonal hematopoiesis of indeterminate potential (CHIP) in individuals older than 70 years. Findin…
Aging blood cell mutations called CHIP quietly raise heart attack risk by fueling inflammation, affecting over 10% of adults over 70.
Meta-analysis finds colchicine associated with reduced MACE in ASCVD, but heterogeneity is substantial
Colchicine linked to fewer heart events in people with existing heart disease
A systematic review and meta-analysis of 5 RCTs (n=18,656 adults with established ASCVD) found colchicine was associated with reduced 4-poin…
A cautious statistical review of five trials found no solid proof that low-dose colchicine reduces major heart events in adults with existin…
Colchicine reduces total plaque burden but not low attenuation plaque in stable CAD patients
Can a cheap anti-inflammatory drug slow heart disease? It might help reduce plaque buildup.
In the EKSTROM RCT (n=84), low-dose colchicine (0.5 mg/day) did not significantly reduce low attenuation plaque volume (median change 0.1 vs…
A cheap anti-inflammatory drug called colchicine may help slow total plaque buildup in arteries for people already managing stable heart dis…
Colchicine reduces arterial stiffness in high-risk T2D patients: RCT
Could a common anti-inflammatory drug help protect the hearts of people with diabetes?
In a 26-week RCT of 100 high-risk patients with type 2 diabetes, colchicine 0.5 mg daily significantly reduced arterial stiffness (MAP-adjus…
A low-dose anti-inflammatory drug called colchicine may help keep arteries flexible and protect heart health in people with type 2 diabetes …
Meta-analysis: Colchicine reduces MACE by 17%, eMACE by 23% in ASCVD
Can an old anti-inflammatory drug help prevent heart attacks? A review of 11 trials suggests it might.
A meta-analysis of 11 trials (n=30,808) found low-dose colchicine was associated with a 17% reduction in MACE (RR 0.83, 95% CI 0.73-0.95; P=…
Adding a low-dose anti-inflammatory drug called colchicine to heart disease treatment lowers the risk of heart attacks and strokes by 17%.