Primary and acquired resistance to immune checkpoint inhibitors in NSCLC involves antigen presentation and TME remodeling
Understanding why some lung cancer treatments do not work for every patient
This systematic review synthesizes mechanisms of primary and acquired resistance to PD-1/PD-L1 inhibitors in patients with non-small cell lu…
Doctors are studying why certain immune-boosting drugs fail to stop lung cancer growth. New insights help find better ways to treat patients…
Immune checkpoint inhibitor regimens for colorectal cancer increase risk of endocrine adverse events
Immunotherapy for colon cancer linked to thyroid problems
This network meta-analysis evaluates endocrine toxicity in patients with colorectal cancer treated with immune checkpoint inhibitor (ICI) ba…
New analysis finds immunotherapy for colorectal cancer raises risk of thyroid issues, especially with certain drug combos.
LncRNA signatures predict ICI response and survival across cancers in systematic review
lncRNA Signatures May Help Predict Response to Cancer Treatment
A systematic review of 31 studies found that lncRNA-based signatures consistently stratify cancer patients into groups with significantly di…
Specific genetic markers called lncRNAs may help doctors predict how well cancer patients will respond to immune checkpoint inhibitor treatm…
Neoadjuvant chemoimmunotherapy improves pathological response and surgical rates in resectable esophageal squamous cell carcinoma
Immune therapy shows promise for esophageal squamous cell carcinoma
This meta-analysis of randomized controlled trials involving 1070 patients found that neoadjuvant chemoimmunotherapy (NIC) significantly imp…
Adding immune checkpoint inhibitors to chemotherapy before surgery significantly improves tumor response rates in patients with esophageal c…
Synergistic Effects of Immune Checkpoint Inhibitors and Radiotherapy in Solid Tumor Management
Combining immune checkpoint inhibitors and radiotherapy improves survival outcomes
Meta-analysis data indicates that combining immune checkpoint inhibitors with radiotherapy significantly improves survival outcomes in solid…
New data shows that adding immune checkpoint inhibitors to radiation therapy can improve survival for patients with many types of solid tumo…
Single-cell and spatial omics provide detailed mapping of tumor-immune ecosystems in non-small cell lung cancer
New Mapping Tools May Improve Lung Cancer Treatment Planning
This mini review explores how single-cell RNA sequencing, chromatin profiling, and spatial transcriptomics offer superior resolution for ana…
Advanced mapping techniques are helping researchers identify how lung cancer cells adapt and hide from current treatments to help plan bette…
Intrathecal chemotherapy provides objective response rates of 34.5% to 86.4% in non-small-cell lung cancer leptomeningeal metastasis
Intrathecal chemotherapy shows promise for lung cancer spreading to brain
This systematic review evaluates intrathecal chemotherapy for patients with leptomeningeal metastasis of non-small-cell lung cancer. The syn…
New data shows that delivering chemotherapy directly into the spinal fluid can help patients with lung cancer that has spread to the lining …
Elevated troponin levels are associated with increased risk of MACE and all-cause mortality in ICI-associated myocarditis
Troponin levels help identify heart inflammation in cancer patients
This meta-analysis evaluates the performance of cardiac troponin as a biomarker for identifying immune checkpoint inhibitor (ICI)-associated…
A new look at cardiac troponin shows it can help doctors spot and predict serious heart risks for patients on certain cancer treatments.
Nanomedicine delivery systems may enhance immunotherapy efficacy in colorectal cancer
Nanomedicine may boost immunotherapy for colorectal cancer
This systematic review explores how nanomedicine delivery systems (liposomes, polymeric nanoparticles, metal nanoparticles) can remodel the …
Tiny particles could help immune therapies work better against colorectal cancer by changing the tumor environment.
Combination of Local Treatment and Systemic Therapy Improves Outcomes in Patients with Hepatocellular Carcinoma
Combining local and systemic treatments improves survival in liver cancer
This meta-analysis evaluated the addition of local treatments like TACE or HAIC to systemic therapy involving immune checkpoint inhibitors a…
Adding local treatments like TACE or HAIC to immunotherapy can improve response rates and extend survival for patients with hepatocellular c…
Pseudoprogression in immune checkpoint inhibitor therapy is associated with modest tumor growth and early progression
Immune Checkpoint Inhibitors May Cause Initial Tumor Growth in Cancer
This meta-analysis of retrospective data examines patients with solid tumors experiencing pseudoprogression during immune checkpoint inhibit…
A growing tumor during immunotherapy might actually be a sign that the treatment is working, not a sign that the cancer is spreading.
Undetectable baseline ctDNA significantly improves progression-free and overall survival in advanced NSCLC patients
Tumor DNA Levels Help Predict Outcomes in Lung Cancer Treatment
This meta-analysis of 2,107 patients evaluates the role of circulating tumor DNA (ctDNA) as a biomarker for outcomes in advanced NSCLC treat…
Testing for circulating tumor DNA may help doctors predict how well patients with advanced lung cancer respond to immunotherapy treatments.