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Home › Medications › methylphenidate

methylphenidate

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of methylphenidate

39 trials tracked of methylphenidate: 22 in phase 3 or 4 and 10 with published results. The most-cited published study has 170 citations.

39Trials tracked
22Phase 3 & 4
0Recruiting
10With published results
Phase distribution
Phase 4 15 Phase 3 7 Phase 2 7 Phase 1 5 Other / NA 5
  1. Phase 3 Treatment of Fatigue With Methylphenidate, Modafinil and Amantadine in Multiple Sclerosis Completed · 170 cited
  2. Phase 4 Treatment of Severe Childhood Aggression (The TOSCA Study) Completed · 140 cited
  3. Phase 3 Methylphenidate and a Nursing Telephone Intervention for Fatigue Completed · 117 cited
  4. Phase 3 Apathy in Dementia Methylphenidate Trial 2 Completed · 109 cited
  5. Phase 4 Stimulant Versus Nonstimulant Medication for Attention Deficit Hyperactivity Disorder in Children Completed · 62 cited
  6. Phase 4 Methylphenidate Treatment of Attention Deficits in Epilepsy Completed · 30 cited
Show 33 more trials
  1. Phase 4 Methylphenidate for Attention Problems After Pediatric TBI Completed · 22 cited
  2. Phase 4 Examining Tolerance to CNS Stimulants in ADHD Completed · 18 cited
  3. Phase 4 Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety Completed · 15 cited
  4. Phase 4 Interventions for Children With Attention and Reading Disorders Completed · 3 cited
  5. Phase 4 Long Acting Stimulant Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Young Children Completed
  6. Phase 4 Control of Cognition (Naltrexone, Methylphenidate, and ADHD Study (NMAS)) Completed
  7. Phase 4 Large-scale Brain Organization During Cognitive Control in ADHD Completed
  8. Phase 4 Methylphenidate for Apathy in Alzheimer's Dementia: A Controlled Study Completed
  9. Phase 4 Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder Completed
  10. Phase 4 Effectiveness of Vyvanse Compared to Concerta in Adolescents With Attention-deficit/Hyperactivity Disorder Completed
  11. Phase 4 Learning Impairments Among Survivors of Childhood Cancer Completed
  12. Phase 4 Response Variability in Children With Attention Deficit Hyperactivity Disorder (ADHD) Completed
  13. Phase 3 Methylphenidate to Improve Balance and Walking in MS Completed
  14. Phase 3 Methylphenidate in Treating Patients With Fatigue Caused by Cancer Completed
  15. Phase 3 Randomized, Double-blind Safety and Efficacy Study of Lisdexamfetamine Dimesylate (LDX) in Children and Adolescents Aged 6-17 Completed
  16. Phase 3 A Study of Pediatric Patients With Attention Deficit/Hyperactivity Disorder Completed
  17. Phase 2 Testing Methylphenidate for Smoking Abstinence Completed
  18. Phase 2 Dopamine Receptor Imaging to Predict Response to Stimulant Therapy in Chronic TBI Completed
  19. Phase 2 Methylphenidate for Ptsd and Stroke Veterans Completed
  20. Phase 2 The Discriminative Effects of Tramadol in Humans Completed
  21. Phase 2 Psychopharmacology for Cocaine Dependence - Buspirone Completed
  22. Phase 2 Apathy in Dementia Methylphenidate Trial (ADMET) Completed
  23. Phase 2 Reversal of General Anesthesia With Methylphenidate Completed
  24. Phase 1 Behavioral Effects of Drugs (Inpatient): 40 [Methamphetamine, Methylphenidate, Duloxetine] Completed
  25. Phase 1 SPD544 High Strength Bioequivalence Study Completed
  26. Phase 1 Effects of Commonly Used Medications on Mood and Choice Completed
  27. Phase 1 Behavioral Effects of Drugs: Inpatient (36) (Alcohol, Duloxetine, and Methylphenidate) Completed
  28. Phase 1 General Anesthesia Emergence Induced by Methylphenidate Completed
  29. N/A Methylphenidate (Ritalin) and Memory/Attention in Traumatic Brain Injury (TBI) Completed
  30. N/A Neurobiological Principles Applied to the Rehabilitation of Stroke Patients Completed
  31. N/A Behavioral Differences in Effortful Control Completed
  32. N/A Methylphenidate for Depressed Cancer Patients Receiving Palliative Care Completed
  33. N/A Gene-environment Interactions and Brain Functional Connectivity in Attention Deficit Hyperactivity Disorder Completed

Showing the 39 most-cited and recently-updated of 39 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Higher ADHD medication doses improve efficacy up to a threshold before benefits plateau
Pediatrics Meta-analysis
Higher ADHD medication doses improve efficacy up to a threshold before benefits plateau Higher ADHD medication doses often stop working or cause more side effects
This network meta-analysis examined oral monotherapy for ADHD in children, adolescents, and adults. Efficacy generally increased with dose u…
A large network analysis of ADHD drugs shows that increasing doses beyond specific limits usually does not improve symptoms and may increase…
Jun 1, 2026
Methylphenidate ER Improves Functional Capacity in Stable Schizophrenia
Psychiatry RCT
Methylphenidate ER Improves Functional Capacity in Stable Schizophrenia Methylphenidate extended-release improved daily function in stable schizophrenia patients
This randomized open-label trial in 24 stable adults with schizophrenia found that 4 weeks of methylphenidate ER improved functional capacit…
A new trial found that methylphenidate extended-release helped adults with schizophrenia spectrum disorder improve daily function and reduce…
May 1, 2026
Case report review suggests LAI paliperidone stabilizes behavior in a 9-year-old with TBI over two years
Psychiatry Sys. Review
Case report review suggests LAI paliperidone stabilizes behavior in a 9-year-old with TBI over two years Long-acting shots help a boy control severe brain injury rage
This case report review describes a 9-year-old boy with severe traumatic brain injury and posttraumatic confusional state treated with long-…
A boy with severe brain injury rage found calm after months of failed pills, showing long-acting shots could help when daily medicine fails
Frontiers Apr 29, 2026
Methylphenidate-treated children with ADHD show wider fQRS-T angles compared to healthy controls in a cross-sectional study
Psychiatry Cohort
Methylphenidate-treated children with ADHD show wider fQRS-T angles compared to healthy controls in a cross-sectional study Could long-term ADHD medication be linked to subtle heart electrical changes?
This single-center, retrospective cross-sectional study compared 75 children and adolescents with DSM-5 ADHD receiving continuous methylphen…
Children taking long-term ADHD medication showed wider heart electrical angles linked to natural inflammation rather than the drug itself.
Frontiers Apr 14, 2026
Early childhood temperament deviations linked to higher ADHD risk in Norwegian cohort study
Psychiatry Cohort
Early childhood temperament deviations linked to higher ADHD risk in Norwegian cohort study Early childhood temperament patterns linked to later ADHD risk in large Norwegian study
A large Norwegian cohort study of over 50,000 children found that deviations from expected temperament development trajectories at ages 1.5,…
Children with unusual early temperament patterns face higher ADHD risk later in life, according to a large Norwegian study of over 50,000 ki…
medRxiv Apr 3, 2026
Methylphenidate plus iron shows earlier response in children with severe ADHD and iron deficiency
Pediatrics RCT
Methylphenidate plus iron shows earlier response in children with severe ADHD and iron deficiency Iron supplements with ADHD medication may help children with both conditions
A small RCT of 50 children with severe ADHD and iron deficiency in Bangladesh compared methylphenidate plus iron to methylphenidate alone ov…
Adding iron supplements to ADHD medication helped children with both conditions improve symptoms faster than medication alone.
Apr 3, 2026
FDA Approves Methylphenidate Hydrochloride Extended-Release Tablets for ADHD and Narcolepsy
Psychiatry FDA Approval
FDA Approves Methylphenidate Hydrochloride Extended-Release Tablets for ADHD and Narcolepsy The FDA has approved a new, longer-acting generic version of a common ADHD and narcolepsy medication
The FDA has approved methylphenidate hydrochloride extended-release tablets for the treatment of Attention Deficit Hyperactivity Disorder (A…
The FDA approved a new generic ADHD and narcolepsy medicine that works for about 8 hours, offering a longer-lasting option for patients 6 ye…
FDA Mar 31, 2026