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Home › Medications › metronidazole

metronidazole

17 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of metronidazole

34 trials tracked of metronidazole: 19 in phase 3 or 4 and 7 with published results. The most-cited published study has 459 citations.

34Trials tracked
19Phase 3 & 4
0Recruiting
7With published results
Phase distribution
Phase 4 6 Phase 3 13 Phase 2 7 Phase 1 3 Other / NA 5
  1. Phase 4 Alternative Antibiotic Regime in the Treatment of GAgP Completed · 459 cited
  2. Phase 3 Compare Ceftazidime-Avibactam + Metronidazole vs Meropenem for Hospitalized Adults With Complicated Intra-Abd Infections Completed · 104 cited
  3. Phase 3 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Completed · 93 cited
  4. Phase 3 Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem for Participants With Complicated Intra-abdominal Infection (MK-7625A-015) Completed · 21 cited
  5. Phase 3 Study of Tedizolid Phosphate in Adolescents With Complicated Skin and Soft Tissue Infection (cSSTI) (MK-1986-012) Completed · 19 cited
  6. Phase 4 Impact of Oral Antibiotic Treatment on C. Difficile Completed · 15 cited
Show 28 more trials
  1. Phase 3 Study to Assess Efficacy and Safety of PF-06947386 in Japanese Adult Patients With Complicated Intra-abdominal Infection Completed · 4 cited
  2. Phase 4 Responses to Rabies Vaccine in Adults With or Without Antibiotics Completed
  3. Phase 4 Trichomonas Vaginalis Recurrence Among HIV+ Women Completed
  4. Phase 4 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed
  5. Phase 4 Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo Completed
  6. Phase 3 Multi-Center Study of New Medications to Treat Vaginal Infections Completed
  7. Phase 3 Multi-Center Study of New Medications to Treat Vaginal Infections Completed
  8. Phase 3 Sulopenem Versus Ertapenem for Complicated Intra-abdominal Infection (cIAI) Completed
  9. Phase 3 Efficacy and Safety of Ertapenem Sodium (MK-0826) Following Colorectal Surgery in Chinese Adults (MK-0826-056) Completed
  10. Phase 3 A Phase 3 Study Of Intravenous Metronidazole For Intrabdominal Infection Completed
  11. Phase 3 Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant Pathogens Completed
  12. Phase 3 Bacterial Vaginosis Home Screening to Prevent STDs Completed
  13. Phase 3 Compare Ceftazidime-Avibactam + Metronidazole Versus Meropenem for Hospitalized Adults With Complicated Intra-Abdominal Infections Completed
  14. Phase 2 Determine the PK and Safety and Tolerability of ATM-AVI for the Treatment of cIAIs in Hospitalized Adults (REJUVENATE) Completed
  15. Phase 2 MK-7625A Plus Metronidazole Versus Meropenem in Pediatric Participants With Complicated Intra-Abdominal Infection (cIAI) (MK-7625A-035) Completed
  16. Phase 2 The Importance of Anti-anaerobic Therapy for Acute Pelvic Inflammatory Disease (PID) Completed
  17. Phase 2 Evaluation of Safety,Pharmacokinetics and Efficacy of CAZ-AVI With Metronidazole in Children Aged 3 Months to 18 Years Old With Complicated Intra-abdominal Infections (cIAIs). Completed
  18. Phase 2 Metronidazole for Pulmonary Tuberculosis (South Korea) Completed
  19. Phase 2 LACTIN-V Study for Recurrent Bacterial Vaginosis Completed
  20. Phase 2 Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers Completed
  21. Phase 1 Metronidazole Pharmacokinetics (PK) in Premature Infants Completed
  22. Phase 1 A Pilot Study of Vancomycin or Metronidazole in Patients With Primary Sclerosing Cholangitis Completed
  23. Phase 1 Bioavailability of Metronidazole Vaginal Gel in Healthy Subjects Completed
  24. N/A Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics Completed
  25. N/A A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions Completed
  26. N/A Compare Sequential and Quadruple Therapy for the Eradication of Helicobacter Pylori in Korea Completed
  27. N/A Drug Use Surveillance of Takecab for "Supplement to Helicobacter Pylori Eradication" Completed
  28. N/A Study of How Bacterial Vaginosis and Its Treatment Affects Cervical and Vaginal Tissue Completed

Showing the 34 most-cited and recently-updated of 34 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Phase 1 trial shows vaginal L. crispatus biotherapeutics colonize in bacterial vaginosis patients
Infectious Disease RCT
Phase 1 trial shows vaginal L. crispatus biotherapeutics colonize in bacterial vaginosis patients A Simple Swab Could Stop Bacterial Vaginosis From Coming Back
A phase 1 randomized trial in 71 participants with bacterial vaginosis in the US and South Africa tested vaginally delivered multi-strain La…
For the millions who struggle with BV that keeps returning, this early research points to a promising new strategy: using beneficial bacteri…
Apr 11, 2026
Intravaginal vitamin C may increase short-term cure and prevent recurrence of bacterial vaginosis
Infectious Disease Meta-analysis
Intravaginal vitamin C may increase short-term cure and prevent recurrence of bacterial vaginosis Intravaginal Vitamin C May Help Treat Bacterial Vaginosis in Nonpregnant Patients
A meta-analysis of 1,107 nonpregnant patients found intravaginal vitamin C (250 mg daily for 6 days) was associated with higher short-term c…
Intravaginal vitamin C cured 66% of bacterial vaginosis patients in short-term trials, outperforming placebo and showing promise against sta…
Apr 9, 2026
Oral and IV metronidazole show similar tissue concentrations in oral cancer flap reconstruction
ENT (Otolaryngology) RCT
Oral and IV metronidazole show similar tissue concentrations in oral cancer flap reconstruction Oral and IV metronidazole show similar tissue levels in small oral cancer surgery study
A randomized trial in 18 patients undergoing FAMM flap reconstruction after oral cancer surgery found no significant difference in tissue AU…
Oral and IV metronidazole reach the same tissue levels in oral cancer surgery, suggesting patients might take the antibiotic by mouth instea…
Apr 8, 2026
Adjunctive antibiotics in peri-implantitis surgery reduce bleeding on probing but not other outcomes
Infectious Disease RCT
Adjunctive antibiotics in peri-implantitis surgery reduce bleeding on probing but not other outcomes Antibiotics with surgery reduced gum bleeding around dental implants in small study
A 12-month RCT in 59 patients with peri-implantitis found that adding systemic amoxicillin and metronidazole to access-flap surgery signific…
Adding antibiotics to dental implant surgery reduced gum bleeding around implants, but offered no other benefits after one year.
Apr 3, 2026
Antibiotic duration and type associated with chronic post-amputation pain in military cohort
Anesthesiology & Pain Medicine Cohort
Antibiotic duration and type associated with chronic post-amputation pain in military cohort Study finds link between antibiotic use and chronic pain after traumatic amputation
A retrospective cohort study of 212 military personnel with traumatic amputations found prolonged antibiotic use (>21 days) and combined reg…
Using antibiotics for more than 21 days or taking two or more types together increased the risk of chronic pain after traumatic amputation i…
Frontiers Apr 3, 2026