Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Medications › metronidazole

metronidazole

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of metronidazole

34 trials tracked of metronidazole: 19 in phase 3 or 4 and 7 with published results. The most-cited published study has 462 citations.

34Trials tracked
19Phase 3 & 4
0Recruiting
7With published results
Phase distribution
Phase 4 6 Phase 3 13 Phase 2 7 Phase 1 3 Other / NA 5
  1. Phase 4 Alternative Antibiotic Regime in the Treatment of GAgP Completed · 462 cited
  2. Phase 3 Compare Ceftazidime-Avibactam + Metronidazole vs Meropenem for Hospitalized Adults With Complicated Intra-Abd Infections Completed · 100 cited
  3. Phase 3 Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis Completed · 93 cited
  4. Phase 3 Study of Tedizolid Phosphate in Adolescents With Complicated Skin and Soft Tissue Infection (cSSTI) (MK-1986-012) Completed · 19 cited
  5. Phase 3 Ceftolozane/Tazobactam (MK-7625A) Plus Metronidazole Versus Meropenem for Participants With Complicated Intra-abdominal Infection (MK-7625A-015) Completed · 19 cited
  6. Phase 4 Impact of Oral Antibiotic Treatment on C. Difficile Completed · 15 cited
Show 28 more trials
  1. Phase 3 Study to Assess Efficacy and Safety of PF-06947386 in Japanese Adult Patients With Complicated Intra-abdominal Infection Completed · 2 cited
  2. Phase 4 Responses to Rabies Vaccine in Adults With or Without Antibiotics Completed
  3. Phase 4 Trichomonas Vaginalis Recurrence Among HIV+ Women Completed
  4. Phase 4 Asymptomatic Bacterial Vaginosis and Herpes Simplex Virus Type 2 (BV/HSV-2) Shedding Study Completed
  5. Phase 4 Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo Completed
  6. Phase 3 Multi-Center Study of New Medications to Treat Vaginal Infections Completed
  7. Phase 3 Multi-Center Study of New Medications to Treat Vaginal Infections Completed
  8. Phase 3 Sulopenem Versus Ertapenem for Complicated Intra-abdominal Infection (cIAI) Completed
  9. Phase 3 Efficacy and Safety of Ertapenem Sodium (MK-0826) Following Colorectal Surgery in Chinese Adults (MK-0826-056) Completed
  10. Phase 3 A Phase 3 Study Of Intravenous Metronidazole For Intrabdominal Infection Completed
  11. Phase 3 Ceftazidime-Avibactam for the Treatment of Infections Due to Ceftazidime Resistant Pathogens Completed
  12. Phase 3 Bacterial Vaginosis Home Screening to Prevent STDs Completed
  13. Phase 3 Compare Ceftazidime-Avibactam + Metronidazole Versus Meropenem for Hospitalized Adults With Complicated Intra-Abdominal Infections Completed
  14. Phase 2 Determine the PK and Safety and Tolerability of ATM-AVI for the Treatment of cIAIs in Hospitalized Adults (REJUVENATE) Completed
  15. Phase 2 MK-7625A Plus Metronidazole Versus Meropenem in Pediatric Participants With Complicated Intra-Abdominal Infection (cIAI) (MK-7625A-035) Completed
  16. Phase 2 The Importance of Anti-anaerobic Therapy for Acute Pelvic Inflammatory Disease (PID) Completed
  17. Phase 2 Evaluation of Safety,Pharmacokinetics and Efficacy of CAZ-AVI With Metronidazole in Children Aged 3 Months to 18 Years Old With Complicated Intra-abdominal Infections (cIAIs). Completed
  18. Phase 2 Metronidazole for Pulmonary Tuberculosis (South Korea) Completed
  19. Phase 2 LACTIN-V Study for Recurrent Bacterial Vaginosis Completed
  20. Phase 2 Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers Completed
  21. Phase 1 Metronidazole Pharmacokinetics (PK) in Premature Infants Completed
  22. Phase 1 A Pilot Study of Vancomycin or Metronidazole in Patients With Primary Sclerosing Cholangitis Completed
  23. Phase 1 Bioavailability of Metronidazole Vaginal Gel in Healthy Subjects Completed
  24. N/A Systems Biology of Flu Vaccine in Healthy Adults With and Without the Use of Antibiotics Completed
  25. N/A A Randomized Controlled Trial of Three Antibiotic Regimens for First Trimester Abortions Completed
  26. N/A Compare Sequential and Quadruple Therapy for the Eradication of Helicobacter Pylori in Korea Completed
  27. N/A Drug Use Surveillance of Takecab for "Supplement to Helicobacter Pylori Eradication" Completed
  28. N/A Study of How Bacterial Vaginosis and Its Treatment Affects Cervical and Vaginal Tissue Completed

Showing the 34 most-cited and recently-updated of 34 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Antibiotic resistance mutations drive H. pylori treatment failure across Asia-Pacific region
Infectious Disease Meta-analysis
Antibiotic resistance mutations drive H. pylori treatment failure across Asia-Pacific region Antibiotic resistance in H. pylori rising across Asia
This meta-analysis of H. pylori infections in the Asia-Pacific region finds that clarithromycin resistance (19-34%) is driven by A2142G/A214…
H. pylori bacteria in Asia are increasingly resistant to common antibiotics, driven by specific mutations.
Jul 3, 2026
Meta-analysis: Nitazoxanide triple therapy improves H. pylori eradication vs standard triple therapy
Infectious Disease Meta-analysis
Meta-analysis: Nitazoxanide triple therapy improves H. pylori eradication vs standard triple therapy Nitazoxanide triple therapy significantly improves H. pylori cure rates compared to standard treatment
This systematic review and meta-analysis of 1286 participants found that nitazoxanide-based triple therapy significantly improved H.
A large review of 1286 patients found that adding nitazoxanide to standard triple therapy significantly improved H. pylori cure rates and re…
May 1, 2026
Meta-analysis: Postoperative oral antibiotics reduce cellulitis after cesarean in obese women
Diabetes & Endocrinology Meta-analysis
Meta-analysis: Postoperative oral antibiotics reduce cellulitis after cesarean in obese women Adding two antibiotics may lower cellulitis risk for obese women having C-sections
This systematic review and meta-analysis of 1144 obese women undergoing cesarean delivery found that adding postoperative oral cephalexin an…
A large review found adding oral cephalexin and metronidazole to standard care significantly reduced cellulitis in obese women after C-secti…
May 1, 2026
FDA Approves Metronidazole Injection for Anaerobic Infections and Prophylaxis
Infectious Disease FDA Approval
FDA Approves Metronidazole Injection for Anaerobic Infections and Prophylaxis FDA approves new antibiotic for serious anaerobic bacterial infections
The FDA approved Metronidazole Injection for treatment of serious anaerobic infections and for prophylaxis in elective colorectal surgery.
The FDA approved Metronidazole Injection USP for serious infections caused by anaerobic bacteria.
FDA Apr 29, 2026
Retrospective study compares antibiotic regimens for H. pylori eradication in children
Pediatrics Cohort
Retrospective study compares antibiotic regimens for H. pylori eradication in children Two antibiotic regimens cleared H. pylori in most children within four weeks
This retrospective observational study evaluated two antibiotic combinations for treating Helicobacter pylori infection in children aged 4 t…
A look at two common treatments found that both regimens successfully eliminated the bacteria in most children within four weeks.
Frontiers Apr 23, 2026
Bismuth-containing quadruple therapy associated with higher H. pylori eradication rates compared to triple therapy in children
Pediatrics Cohort
Bismuth-containing quadruple therapy associated with higher H. pylori eradication rates compared to triple therapy in children New Mix Clears Stomach Bugs Better in Children
This retrospective cohort study of 161 pediatric patients compared 14-day bismuth-containing quadruple therapy against triple therapy for He…
A four-drug plan works better than the usual three-drug plan for clearing stomach bacteria in kids.
Frontiers Apr 22, 2026
Cross-sectional study in South Benin finds metronidazole prescribing linked to symptoms
Infectious Disease
Cross-sectional study in South Benin finds metronidazole prescribing linked to symptoms A Common Antibiotic Is Being Widely Prescribed — but Is It Always the Right Call?
A register-based cross-sectional study of 2,200 medical visits in South Benin primary care found metronidazole prescribing was associated wi…
In Benin, a common gut infection antibiotic is prescribed in nearly one in five clinic visits, raising urgent questions about whether it is …
medRxiv Apr 18, 2026
H. pylori eradication reduces cholesterol and LDL in patients with cardiovascular disease risk
Infectious Disease RCT
H. pylori eradication reduces cholesterol and LDL in patients with cardiovascular disease risk Treating This Stomach Bug May Quietly Lower Heart Risk
A randomized controlled trial in 72 patients with H.
Treating a common stomach infection can lower cholesterol and small dense lipoprotein particles a year later, potentially reducing heart dis…
Apr 15, 2026
Phase 1 trial shows vaginal L. crispatus biotherapeutics colonize in bacterial vaginosis patients
Infectious Disease RCT
Phase 1 trial shows vaginal L. crispatus biotherapeutics colonize in bacterial vaginosis patients A Simple Swab Could Stop Bacterial Vaginosis From Coming Back
A phase 1 randomized trial in 71 participants with bacterial vaginosis in the US and South Africa tested vaginally delivered multi-strain La…
For the millions who struggle with BV that keeps returning, this early research points to a promising new strategy: using beneficial bacteri…
Apr 11, 2026
Intravaginal vitamin C may increase short-term cure and prevent recurrence of bacterial vaginosis
Infectious Disease Meta-analysis
Intravaginal vitamin C may increase short-term cure and prevent recurrence of bacterial vaginosis Intravaginal Vitamin C May Help Treat Bacterial Vaginosis in Nonpregnant Patients
A meta-analysis of 1,107 nonpregnant patients found intravaginal vitamin C (250 mg daily for 6 days) was associated with higher short-term c…
Intravaginal vitamin C cured 66% of bacterial vaginosis patients in short-term trials, outperforming placebo and showing promise against sta…
Apr 9, 2026
Oral and IV metronidazole show similar tissue concentrations in oral cancer flap reconstruction
ENT (Otolaryngology) RCT
Oral and IV metronidazole show similar tissue concentrations in oral cancer flap reconstruction Oral and IV metronidazole show similar tissue levels in small oral cancer surgery study
A randomized trial in 18 patients undergoing FAMM flap reconstruction after oral cancer surgery found no significant difference in tissue AU…
Oral and IV metronidazole reach the same tissue levels in oral cancer surgery, suggesting patients might take the antibiotic by mouth instea…
Apr 8, 2026
Adjunctive antibiotics in peri-implantitis surgery reduce bleeding on probing but not other outcomes
Infectious Disease RCT
Adjunctive antibiotics in peri-implantitis surgery reduce bleeding on probing but not other outcomes Antibiotics with surgery reduced gum bleeding around dental implants in small study
A 12-month RCT in 59 patients with peri-implantitis found that adding systemic amoxicillin and metronidazole to access-flap surgery signific…
Adding antibiotics to dental implant surgery reduced gum bleeding around implants, but offered no other benefits after one year.
Apr 3, 2026

All metronidazole Articles