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Home › Medications › midazolam

midazolam

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of midazolam

134 trials tracked of midazolam: 42 in phase 3 or 4 and 17 with published results. The most-cited published study has 424 citations.

134Trials tracked
42Phase 3 & 4
0Recruiting
17With published results
Phase distribution
Phase 4 27 Phase 3 15 Phase 2 15 Phase 1 59 Other / NA 18
  1. Phase 4 Ketamine in the Treatment of Suicidal Depression Completed · 424 cited
  2. Phase 3 A Phase III Study of Remimazolam in Patients Undergoing Bronchoscopy Completed · 314 cited
  3. Phase 3 A Phase III Study of the Efficacy and Safety of Remimazolam Compared to Placebo and Midazolam in Colonoscopy Patients Completed · 304 cited
  4. Phase 4 Ketamine For Suicidal Ideation Completed · 297 cited
  5. Phase 3 Intranasal Dexmedetomidine Premedication in Children Completed · 282 cited
  6. Phase 3 Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD) Completed · 232 cited
Show 44 more trials
  1. Phase 4 The Effect of Different Sedation Regimes on Cognitive Function in Lower Gastrointestinal System Endoscopy Completed · 169 cited
  2. Phase 3 Music vs Midazolam During Preop Nerve Block Placement Completed · 79 cited
  3. Phase 4 The Platelet Aggregation After tiCagrelor Inhibition and FentanYl Trial (PACIFY) Completed · 67 cited
  4. Phase 4 UNderstanding CONSciousness Connectedness and Intraoperative Unresponsiveness Study Completed · 61 cited
  5. Phase 4 Oral Versus Intravenous Sedation for Ocular Procedures Completed · 51 cited
  6. Phase 4 Propofol vs. Midazolam-based Balanced Propofol for Nonanesthesiologist Moderate Sedation in Colonoscopy Completed · 42 cited
  7. Phase 4 Evaluation of Oral Midazolam in First-trimester Surgical Abortions Completed · 26 cited
  8. Phase 4 Ketamine Infusion for Adolescent Depression and Anxiety Completed · 20 cited
  9. Phase 3 An Open-Label Immunogenicity and Pharmacokinetics Study of Daclizumab High Yield Process Prefilled Syringe in Relapsing Remitting Multiple Sclerosis Completed · 16 cited
  10. Phase 3 Ketamine for Treatment Resistant Late-Life Depression Completed · 12 cited
  11. Phase 3 Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old Completed · 8 cited
  12. Phase 4 Intranasal Midazolam for Treatment of Anxiety in Children Undergoing Suturing in the Pediatric Emergency Department Completed
  13. Phase 4 Intranasal Dexmedetomidine vs Intranasal Midazolam as Anxiolysis Prior to Pediatric Laceration Repair Completed
  14. Phase 4 The Combination of Adductor Canal Block and Periarticular Injection. A Novel Technique for Patients Undergoing Total Knee Replacement (ACB PAI) Completed
  15. Phase 4 A Non-inferiority Trial on Pain Relief During Oocyte Retrieval Completed
  16. Phase 4 Intranasal Midazolam in Children as a Pre-Operative Sedative - Part 2 Completed
  17. Phase 4 A Comparison of Intranasal Midazolam and Nitrous Oxide (N2O) Minimal Sedation for Minor Procedures in a Pediatric Emergency Department Completed
  18. Phase 4 Comparing Pediatric Dental Oral Sedation Outcomes With and Without Meperidine in Children Aged 3-7 Years Completed
  19. Phase 4 Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative Medication Completed
  20. Phase 4 Propofol Administered by Gastroenterologists by Target Controlled Infusion Pump During Endoscopy Completed
  21. Phase 4 Etomidate vs. Midazolam for Sedation During ERCP Completed
  22. Phase 4 Study to Evaluate Effect of Belatacept on Pharmacokinetics of Inje Cocktail in Healthy Volunteers Completed
  23. Phase 4 Study Evaluating the Effect of Desvenlafaxine on the Pharmacokinetics of Midazolam Completed
  24. Phase 4 Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy Completed
  25. Phase 4 Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine. Completed
  26. Phase 4 Does Preop Midazolam Maintain Blood Glucose Norms in the Non Diabetic Perioperative Period Completed
  27. Phase 4 Ultrasound-guided Axillary Plexus Block - Dose Reduction of Prilocaine Completed
  28. Phase 4 Open-Label, Safety Study Evaluating the Use of Dexmedetomidine in Pediatric Subjects Undergoing Procedure-Type Sedation Completed
  29. Phase 4 Intranasal Midazolam in Children as a Pre-Operative Sedative Completed
  30. Phase 3 A Comparison of Midazolam and Zolpidem as Oral Premedication in Children Completed
  31. Phase 3 Safety and Efficacy of Remimazolam in ASA III and IV Patients Undergoing Colonoscopy Completed
  32. Phase 3 Open-Label, Safety, and Efficacy Study of Dexmedetomidine in Preterm Subjects Ages ≥28 Weeks to <36 Weeks Gestational Age Completed
  33. Phase 3 Study Evaluating Safety and Efficacy of Dexmedetomidine (DEX) in Intubated and Mechanically Ventilated Pediatric Intensive Care Unit (PICU) Subjects Completed
  34. Phase 3 Dexmedetomidine Versus Fentanyl Following Pressure Equalization Tube Placement Completed
  35. Phase 3 Evaluate the Use of Paravertebral Block in Reconstructive Breast Surgery Completed
  36. Phase 3 Safety, Efficacy and Pharmacokinetic Study of Dexmedetomidine in Pediatrics Ages ≥28 Weeks to ≤44 Weeks Gestational Age Completed
  37. Phase 2 Analgesic Effect of IV Acetaminophen in Tonsillectomies Completed
  38. Phase 2 PREMIX vs PREMED Intranasal Lidocaine and Midazolam Completed
  39. Phase 2 Effect of Ketamine on Laboratory-induced Stress in Healthy Subjects Completed
  40. Phase 2 Optimization of IV Ketamine for Treatment Resistant Depression Completed
  41. Phase 2 Intranasal Midazolam Versus Rectal Diazepam for Treatment of Seizures Completed
  42. Phase 2 Dose Escalation Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics of ASP2215 in Patients With Relapsed or Refractory Acute Myeloid Leukemia Completed
  43. Phase 2 Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for Suicide Completed
  44. Phase 2 A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue Completed

Showing the 50 most-cited and recently-updated of 134 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Nalbuphine and midazolam show non-inferiority to pethidine and midazolam for oocyte retrieval pain
OB/GYN & Women's Health RCT
Nalbuphine and midazolam show non-inferiority to pethidine and midazolam for oocyte retrieval pain Nalbuphine Matches Old Painkiller For Egg Retrieval
In this double-blinded, non-inferiority randomized controlled trial of 94 participants, 10 mg intravenous nalbuphine with 5 mg midazolam was…
A new painkiller matches the old standard for egg retrieval without causing more side effects.
Frontiers Apr 30, 2026
Increasing midazolam sedation levels associated with decreased energy expenditure in mechanically ventilated patients
Rheumatology Cohort
Increasing midazolam sedation levels associated with decreased energy expenditure in mechanically ventilated patients Deep sedation reduces energy use in critically ill patients
In this prospective self-controlled study of 74 critically ill patients requiring mechanical ventilation, increasing levels of midazolam sed…
Deep sedation levels can lower how much energy the body burns in patients using mechanical ventilation.
Frontiers Apr 30, 2026
Network meta-analysis of ketamine regimens for pediatric ED procedural sedation safety and efficacy
Pediatrics Meta-analysis
Network meta-analysis of ketamine regimens for pediatric ED procedural sedation safety and efficacy Ketamine combos ease pain in kids with less nausea
This network meta-analysis evaluated ketamine-based regimens versus IV ketamine for pediatric procedural sedation in the emergency departmen…
A new analysis reveals a ketamine-propofol mix calms injured children faster and with fewer side effects than ketamine alone.
Apr 29, 2026
Intranasal Dexmedetomidine Plus Midazolam Improves Sedation Success Versus Chloral Hydrate in Children
Drug Pipeline RCT
Intranasal Dexmedetomidine Plus Midazolam Improves Sedation Success Versus Chloral Hydrate in Children Dexmedetomidine Plus Midazolam Works Better for Kids
This randomized controlled trial enrolled 180 children aged 1–6 years undergoing outpatient procedural sedation.
A common sedation combo for children fails more often and causes more side effects than a better alternative most clinics already use.
Frontiers Apr 25, 2026
Network meta-analysis of sedation strategies in therapeutic gastrointestinal endoscopy shows ketamine-propofol reduces hypoxia and bradycardia versus propofol-opioid
Drug Pipeline Meta-analysis
Network meta-analysis of sedation strategies in therapeutic gastrointestinal endoscopy shows ketamine-propofol reduces hypoxia and bradycardia versus propofol-opioid Better Sedation Choices Could Reduce Side Effects During Stomach Tests
This network meta-analysis evaluated pharmacological sedation strategies in 7,071 patients undergoing therapeutic gastrointestinal endoscopy…
Mixing ketamine with propofol lowers breathing and blood pressure risks for patients undergoing long stomach procedures compared to standard…
Frontiers Apr 21, 2026
Meta-analysis shows dexmedetomidine lowers mean arterial pressure compared to midazolam-fentanyl in surgical patients
Anesthesiology & Pain Medicine Meta-analysis
Meta-analysis shows dexmedetomidine lowers mean arterial pressure compared to midazolam-fentanyl in surgical patients A Calmer Sedative May Make Surgery Safer for Patients
This systematic review and meta-analysis evaluated 259 surgical patients receiving either dexmedetomidine or midazolam-fentanyl during intra…
A newer sedative keeps patients calmer with steadier vitals and fewer breathing problems than the older standard combination during surgery.
Frontiers Apr 15, 2026
Outpatient IV sedation for dental care in special needs patients shows 3.3% minor complication rate
Dermatology Cohort
Outpatient IV sedation for dental care in special needs patients shows 3.3% minor complication rate Study describes use of IV sedation for dental care in patients with special needs
A retrospective cohort study of 212 special health care needs patients (mean age 11.1 years) undergoing outpatient IV sedation for dental pr…
Over 2,200 dental procedures were safely performed on children with autism and Down syndrome using IV sedation at a Venezuelan clinic, with …
Frontiers Apr 8, 2026