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Home › Conditions › Critically Ill

Critically Ill

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Critically Ill

13 trials tracked for Critically Ill: 3 in phase 3 or 4.

13Trials tracked
3Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 1 Phase 3 2 Phase 2 2 Phase 1 1 Other / NA 7
  1. Phase 4 Pharmacokinetics of Daptomycin in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis (CVVHD) Completed
  2. Phase 3 Impact of SPN on Infection Rate, Duration of Mechanical Ventilation & Rehabilitation in ICU Patients Completed
  3. Phase 3 Hypocaloric Nutrition in Critically Ill Patients Completed
  4. Phase 2 The Effect of Thiamine vs. Placebo on VO2 in Critical Illness Completed
  5. Phase 2 Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury Completed
  6. Phase 1 Plasma Pharmacokinetics (PK) & Lung Penetration of Ceftolozane/Tazobactam in Participants With Pneumonia (MK-7625A-007) Completed
Show 7 more trials
  1. N/A Is There Any Correlation Between Respiratory Variation Ratios of Internal Jugular Vein and Inferior Vena Cava? Completed
  2. N/A Efficacy Study on Silver-coated ETT Cleaned With a Novel Device Completed
  3. N/A Testing of a New Therapeutic Vibration Device to Reduce Neuromuscular Weakness in Hospitalized Patients Completed
  4. N/A A Randomized, Controlled Trial of Inspiratory Muscle Training (IMT)in the ICU and CCU Completed
  5. N/A 24 Hour Intensivist Coverage in the Medical Intensive Care Unit Completed
  6. N/A NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock Completed
  7. N/A Enhanced Protein-Energy Provision Via the Enteral Route in Critically Ill Patients Completed

Showing the 13 most-cited and recently-updated of 13 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Conservative oxygen targets show no mortality difference in mechanically ventilated critically ill adults
Emergency Medicine Meta-analysis
Conservative oxygen targets show no mortality difference in mechanically ventilated critically ill adults New Oxygen Rules Save Lives Without Extra Risk in ICU
This systematic review and meta-analysis of 20,447 mechanically ventilated critically ill adults in the ICU found no substantial difference …
ICU teams can safely use less oxygen for ventilated patients, new research shows, potentially reducing harm without raising death risk for m…
May 8, 2026
Increasing midazolam sedation levels associated with decreased energy expenditure in mechanically ventilated patients
Rheumatology Cohort
Increasing midazolam sedation levels associated with decreased energy expenditure in mechanically ventilated patients Deep sedation reduces energy use in critically ill patients
In this prospective self-controlled study of 74 critically ill patients requiring mechanical ventilation, increasing levels of midazolam sed…
Deep sedation levels can lower how much energy the body burns in patients using mechanical ventilation.
Frontiers Apr 30, 2026
Conservative fluid management shows no difference in tissue perfusion or kidney injury in critically ill adults
Emergency Medicine RCT
Conservative fluid management shows no difference in tissue perfusion or kidney injury in critically ill adults Less Fluid in ICU: New Data Shows It Is Safe
This secondary analysis of an RCT in critically ill patients found that conservative fluid management with active deresuscitation did not di…
Doctors can safely reduce fluids in sick patients without hurting their organs.
Apr 23, 2026
Individualized commercial formulation reduces diarrhea in adult ICU patients receiving tube-fed enteral nutrition
Nutrition & Obesity Medicine Cohort
Individualized commercial formulation reduces diarrhea in adult ICU patients receiving tube-fed enteral nutrition Custom-Made Nutrition Cuts Diarrhea Risk in Half for ICU Patients
This retrospective cohort study of 605 adult ICU patients at Henan Provincial People's Hospital compared individualized commercial formulati…
For patients in the ICU who can’t eat normally, switching from a standard "one-size-fits-all" nutrition formula to a custom-made one could d…
Frontiers Apr 23, 2026
Protocol outlines individualized anticoagulation monitoring in critically ill adults using unfractionated or low-molecular-weight heparin
Rheumatology Cohort
Protocol outlines individualized anticoagulation monitoring in critically ill adults using unfractionated or low-molecular-weight heparin ICU Blood Clot Prevention Has a Monitoring Problem — This Study Aims to Fix It
This study protocol describes a prospective observational cohort design evaluating individualized anticoagulation monitoring in critically i…
A new prospective study is testing whether a real-time clotting test called viscoelastic testing can give ICU doctors a more complete pictur…
Frontiers Apr 18, 2026
Testosterone gel fails to normalize serum levels in critically ill ICU patients in pilot RCT
Emergency Medicine RCT
Testosterone gel fails to normalize serum levels in critically ill ICU patients in pilot RCT Can testosterone gel help critically ill men? A small study finds no clear benefit
A pilot RCT of 30 critically ill ICU patients on vasopressors and mechanical ventilation found 14-day testosterone gel administration did no…
Testosterone gel did not improve hormone levels or safety in critically ill men needing breathing machines and blood pressure support.
Apr 2, 2026