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Home › Medications › minocycline

minocycline

11 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of minocycline

48 trials tracked of minocycline: 13 in phase 3 or 4 and 1 with published results. The most-cited published study has 74 citations.

48Trials tracked
13Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 9 Phase 3 4 Phase 2 24 Phase 1 1 Other / NA 10
  1. Phase 3 Minocycline and Aspirin in the Treatment of Bipolar Depression Completed · 74 cited
  2. Phase 4 Minocycline for Bipolar Depression Completed
  3. Phase 4 Administration of Oral Extended Release Minocycline for Assessment of Skin and Plasma Concentrations of Minocycline Completed
  4. Phase 4 Minocycline Augmentation to Clozapine Completed
  5. Phase 4 Minocycline for Treatment of Posttraumatic Stress Disorder in Veterans Completed
  6. Phase 4 Minocycline Pharmacokinetics (ACUMIN) Completed
Show 42 more trials
  1. Phase 4 Minocycline and Tobacco Craving in Smokers With Schizophrenia Completed
  2. Phase 4 Brain and Stress Study Completed
  3. Phase 4 The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis Completed
  4. Phase 4 Minocycline to Treat Childhood Regressive Autism Completed
  5. Phase 3 Neuroprotection in Acute Ischemic Stroke Completed
  6. Phase 3 Antibiotic Study for Dental Implants Completed
  7. Phase 3 Pilot Study of Minocycline in Huntington's Disease Completed
  8. Phase 2 Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy Completed
  9. Phase 2 Minocycline Hydrochloride in Reducing Chemotherapy-Induced Peripheral Neuropathy and Acute Pain in Patients With Breast Cancer Undergoing Treatment With Paclitaxel Completed
  10. Phase 2 Minocycline in Patients With Alzheimer's Disease Completed
  11. Phase 2 Study 3: Minocycline Decreases Microglia Activation Completed
  12. Phase 2 Open Label Photo-Documentation Study Of BPX-01 Minocycline Gel Completed
  13. Phase 2 Minocycline Study in Pancreatic Cancer Patients Completed
  14. Phase 2 Prevention of Treatment Induced Neuropathy in Multiple Myeloma Completed
  15. Phase 2 Study of a Neuroprotective Drug to Limit the Extent of Damage From an Ischemic Stroke Completed
  16. Phase 2 Safety and Feasibility of Minocycline in the Treatment of Traumatic Brain Injury (TBI) Completed
  17. Phase 2 Intervention for Symptom Burden During Maintenance Therapy for Multiple Myeloma Completed
  18. Phase 2 Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients Completed
  19. Phase 2 Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration Completed
  20. Phase 2 Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD Completed
  21. Phase 2 Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Randomized Study. Completed
  22. Phase 2 Systemic and Topical Treatments for Rash Secondary to Erlotinib in Lung Cancer Completed
  23. Phase 2 Minocycline Hydrochloride in Reducing Chemotherapy Induced Depression and Anxiety in Patients With Stage I-III Breast Cancer Completed
  24. Phase 2 A Pilot Study for the Evaluation of Minocycline as a Microglia Inhibitor in the Treatment of Diabetic Macular Edema Completed
  25. Phase 2 A Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer Completed
  26. Phase 2 Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma Completed
  27. Phase 2 Minocycline to Treat Branch Retinal Vein Occlusion Completed
  28. Phase 2 Minocycline to Treat Central Retinal Vein Occlusion Completed
  29. Phase 2 A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients Completed
  30. Phase 2 Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa Completed
  31. Phase 2 Minocycline to Reduce Pain After Carpal Tunnel Release Completed
  32. Phase 1 Neurophysiological and Acute Pharmacological Studies in FXS Patients Completed
  33. N/A Minocycline in the Treatment of Angelman Syndrome Completed
  34. N/A The Effects of Minocycline in Opioid-maintained Patients Completed
  35. N/A Add-on Pilot Trial of Minocycline to Treat Fragile X Syndrome Completed
  36. N/A Open Treatment of Minocycline in Geriatric Depression Completed
  37. N/A Minocycline to Prevent Acute Kidney Injury After Cardiac Surgery Completed
  38. N/A A Study for Reducing Symptom Burden Produced by Chemoradiation Treatment for Non Small Cell Lung Cancer by Minocycline and Armodafinil Completed
  39. N/A Kidney and Periodontal Disease Study Completed
  40. N/A Trial of Minocycline to Treat Children With Fragile X Syndrome Completed
  41. N/A Adjunctive Minocycline in Clozapine Treated Schizophrenia Patients Completed
  42. N/A Depression, Obesity and Inflammatory Markers Completed

Showing the 48 most-cited and recently-updated of 48 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Minocycline reduces 3-month NIH Stroke Scale scores by 2.43 in acute ischemic stroke
Neurology Meta-analysis
Minocycline reduces 3-month NIH Stroke Scale scores by 2.43 in acute ischemic stroke Minocycline may improve recovery for some patients after ischemic stroke
This meta-analysis of 2186 patients with acute ischemic and intracerebral hemorrhage evaluated the impact of minocycline on neurological out…
A review of clinical data suggests the antibiotic minocycline could help some patients regain function after an ischemic stroke.
NEJM Oct 28, 2026
G-CSF shows potential signal for neurological grade improvement in acute spinal cord injury
Drug Pipeline Meta-analysis
G-CSF shows potential signal for neurological grade improvement in acute spinal cord injury G-CSF Shows Potential for Improving Spinal Cord Injury Recovery
This meta-analysis evaluates the efficacy of G-CSF, EPO, MP, and minocycline for neurological grade improvement in acute spinal cord injury.…
A review of treatments for acute spinal cord injury suggests that G-CSF may help improve neurological grades, though more evidence is needed…
Frontiers Oct 11, 2026
Minocycline-based regimens are noninferior to bismuth quadruple therapy for refractory H. pylori eradication
Infectious Disease RCT
Minocycline-based regimens are noninferior to bismuth quadruple therapy for refractory H. pylori eradication New minocycline treatment shows promise for stubborn stomach infections
This randomized controlled trial of 480 participants with refractory H. pylori infection found that three minocycline-containing regimens we…
A new study shows that minocycline-based treatments are as effective as standard options for clearing tough, treatment-resistant stomach inf…
Oct 5, 2026
Levofloxacin improves survival versus TMP-SMX in multidrug-resistant S. maltophilia infections
Infectious Disease Sys. Review
Levofloxacin improves survival versus TMP-SMX in multidrug-resistant S. maltophilia infections Levofloxacin Shows Better Survival for Multidrug-Resistant Stenotrophomonas Infections
This systematic review and meta-analysis evaluated levofloxacin, minocycline, tigecycline, and TMP-SMX for multidrug-resistant Stenotrophomo…
Levofloxacin may improve survival rates for patients with multidrug-resistant Stenotrophomonas maltophilia infections compared to standard t…
Oct 3, 2026
Minocycline 40 mg outperforms doxycycline for rosacea in meta-analysis
Infectious Disease Meta-analysis
Minocycline 40 mg outperforms doxycycline for rosacea in meta-analysis Minocycline Shows Better Success Rates for Treating Rosacea
A meta-analysis of 643 rosacea patients found minocycline 40 mg extended-release significantly improved treatment success versus modified-re…
A new extended-release minocycline may be more effective than doxycycline for reducing inflammatory lesions in patients with rosacea.
Sep 25, 2026
Propofol outperforms sevoflurane and midazolam in preventing delayed neurocognitive recovery during surgery
Drug Pipeline Meta-analysis
Propofol outperforms sevoflurane and midazolam in preventing delayed neurocognitive recovery during surgery Propofol May Offer Better Protection Against Post-Surgery Cognitive Issues
This meta-analysis of 9,636 patients evaluated 18 interventions for preventing delayed neurocognitive recovery. Propofol showed statisticall…
A large review of surgical data suggests that propofol may be more effective than other anesthetics at preventing delayed cognitive recovery…
Frontiers Sep 24, 2026
Dapsone 5% and erythromycin 2% significantly reduce inflammatory lesion counts in acne vulgaris
Infectious Disease Sys. Review
Dapsone 5% and erythromycin 2% significantly reduce inflammatory lesion counts in acne vulgaris Trial shows specific antibiotics help treat certain types of acne
This network meta-analysis of 22,645 patients evaluated various topical antibiotic monotherapies for acne vulgaris. While specific agents li…
New data identifies which topical antibiotics are most effective at reducing different types of acne lesions while highlighting risks like a…
Aug 7, 2026
Quadruple antimycobacterial regimen achieves clinical stability in cystic fibrosis patient with M. abscessus
Pediatrics Sys. Review
Quadruple antimycobacterial regimen achieves clinical stability in cystic fibrosis patient with M. abscessus Case report shows quadruple regimen for cystic fibrosis infection
A case report and literature review describes a 21-year-old man with cystic fibrosis and Mycobacterium abscessus infection who achieved clin…
A young man with cystic fibrosis and a hard-to-treat infection achieved stability using a four-drug antimycobacterial regimen.
Frontiers Jun 2, 2026
Case report of multidrug resistant Myroides odoratimimus infection in a gastric cancer patient
Infectious Disease Sys. Review
Case report of multidrug resistant Myroides odoratimimus infection in a gastric cancer patient Rare bacteria shows resistance to most common antibiotics
This case report describes a single instance of Myroides odoratimimus infection in a patient with gastric cancer.
A single case study reveals a rare urinary infection that resisted 23 out of 24 antibiotics tested in a laboratory setting.
Frontiers Apr 30, 2026
Systematic review identifies specific medications significantly associated with drug-induced hyperpigmentation across diverse drug classes
Drug Pipeline Meta-analysis
Systematic review identifies specific medications significantly associated with drug-induced hyperpigmentation across diverse drug classes These Common Meds Might Be Darkening Your Skin
A systematic review and meta-analysis evaluated twenty-two studies regarding the incidence of drug-induced hyperpigmentation.
A major review reveals many common medicines can cause noticeable skin darkening.
Frontiers Apr 24, 2026
Systematic review finds limited evidence for antibiotics in low back pain with Modic changes
Geriatrics & Aging Sys. Review
Systematic review finds limited evidence for antibiotics in low back pain with Modic changes Antibiotics Might Ease Back Pain for Some
A systematic review of 3 RCTs (402 adults) found amoxicillin may slightly reduce pain and disability at 12-14 weeks in patients with low bac…
For people with low back pain and specific MRI changes, antibiotics could treat the root cause instead of just masking the pain.
Cochrane Apr 11, 2026