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Home › Conditions › Low Back Pain

Low Back Pain

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Low Back Pain

223 trials tracked for Low Back Pain: 69 in phase 3 or 4 and 18 with published results. The most-cited published study has 369 citations.

223Trials tracked
69Phase 3 & 4
0Recruiting
18With published results
Phase distribution
Phase 4 27 Phase 3 42 Phase 2 22 Other / NA 132
  1. Phase 4 Lumbar Epidural Steroid Injections for Spinal Stenosis Multicenter Randomized, Controlled Trial (LESS Trial) Completed · 369 cited
  2. Phase 3 Osteopathic Health Outcomes in Chronic Low Back Pain (OSTEOPATHIC) Trial Completed · 184 cited
  3. Phase 3 Study to Test the Effectiveness of Controlled-Release OROS® Hydromorphone HCl Compared to Placebo in Patients With Chronic Low Back Pain Completed · 81 cited
  4. Phase 4 Comparison of Increasing Doses of Tapentadol Versus a Combination of Tapentadol and Pregabalin Completed · 71 cited
  5. Phase 4 Orphenadrine and Methocarbamol for LBP Completed · 68 cited
  6. Phase 3 Long-Term Safety and Tolerability Study of NKTR-181 in Subjects With Chronic Low Back Pain or Chronic Non-Cancer Pain Completed · 68 cited
Show 44 more trials
  1. Phase 3 A Phase 3 Study of Tanezumab for Chronic Low Back Pain Completed · 57 cited
  2. Phase 4 Ibuprofen Plus Metaxolone, Tizanidine, or Baclofen for Low Back Pain Completed · 50 cited
  3. Phase 4 Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain Patients Completed · 47 cited
  4. Phase 3 Oxycodone DETERx™ Versus Placebo in Chronic Low Back Pain (CLBP) Completed · 35 cited
  5. Phase 3 A Research Study of an Investigational Drug ALO-02 (Oxycodone Hydrochloride and Naltrexone Hydrochloride) in Patients With Moderate to Severe Chronic Low Back Pain Completed · 29 cited
  6. Phase 3 Efficacy and Safety Study of NKTR-181 in Opioid-Naive Subjects With Low Back Pain Completed · 29 cited
  7. Phase 4 Placebo In Chronic Back Pain - Double-Blind Randomized Control Trial Completed · 17 cited
  8. Phase 4 Placebo In Chronic Back Pain (Phase 2) Completed · 16 cited
  9. Phase 4 Determining the Prognostic Value of Continuous Intrathecal Infusion Completed · 11 cited
  10. Phase 3 Long Term Safety and Efficacy Study of Tanezumab in Japanese Adult Subjects With Chronic Low Back Pain Completed · 10 cited
  11. Phase 4 The BEST Trial: Biomarkers for Evaluating Spine Treatments Completed · 7 cited
  12. Phase 4 Study Evaluating Dexketoprofen Trometamol/Tramadol Hydrochloride Analgesic Efficacy in Acute Low Back Pain Completed · 7 cited
  13. Phase 4 Opioid Treatment for Chronic Low Back Pain and the Impact of Mood Symptoms Completed
  14. Phase 4 Brain Effects of Opiate Agonist and Antagonist Completed
  15. Phase 4 A Comparison of NSAIDs for Acute, Non-radicular Low Back Pain. Completed
  16. Phase 4 Effectiveness of Ultrasound Guided Platelet Rich Plasma Injections in the Sacroiliac Joint Completed
  17. Phase 4 Acute Low Back Pain. Topical Diclofenac and Oral Ibuprofen. Completed
  18. Phase 4 Effect of Combined Morphine and Duloxetine on Chronic Pain Completed
  19. Phase 4 The Back Pain Consortium Research Program Study Completed
  20. Phase 4 True Functional Restoration and Analgesia in Non-Radicular Low Back Pain Completed
  21. Phase 4 Tapentadol Prolonged Release (PR) Versus Oxycodone/Naloxone Prolonged Release in Severe Chronic Low Back Pain With a Neuropathic Component. Completed
  22. Phase 4 High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System Completed
  23. Phase 4 Study Of Disc Anaesthesia For The Preoperative Diagnosis Of Chronic Lower Back Pain Completed
  24. Phase 4 An Efficacy and Safety Study of Fentanyl Transdermal Patch in Filipino Participants With Osteoarthritis and Chronic Low Back Pain Completed
  25. Phase 4 The Glucosamine-study: The Effect of Glucosamine in Treatment of Chronic Low Back Pain Completed
  26. Phase 4 An Efficacy and Safety Study of Transdermal Therapeutic System (TTS)-Fentanyl in Severe Chronic Low Back Pain Completed
  27. Phase 4 Brain Imaging of Lidoderm for Chronic Back Pain Completed
  28. Phase 4 TissueLink Study During Multi-Level Spine Surgery Completed
  29. Phase 4 An Efficacy and Safety Study of Tramadol Hydrochloride-Paracetamol in Treatment of Moderate to Severe Acute Neck-Shoulder Pain and Low Back Pain Completed
  30. Phase 3 Efficacy and Safety of Finalgon® Cream Multiple Doses in Acute Low Back Pain Completed
  31. Phase 3 Efficacy and Safety of Hydrocodone Bitartrate Extended-Release Tablets for Moderate to Severe Chronic Low Back Pain Completed
  32. Phase 3 Open-Label, Extension Study to Evaluate the Safety of Hydrocodone Bitartrate Extended-Release Tablets Completed
  33. Phase 3 Diazepam Use With Standard Management for Acute Low Back Pain Completed
  34. Phase 3 Longterm Safety Study of BEMA Buprenorphine in Subjects With Chronic Pain Completed
  35. Phase 3 Long-term Open-Label Safety Study to Evaluate EN3409 Completed
  36. Phase 3 A Study to Determine the Efficacy and Safety of Fasinumab for the Treatment of Adults With Chronic Low Back Pain Completed
  37. Phase 3 Study of COV795 in Subjects With Osteoarthritis or Chronic Low Back Pain Completed
  38. Phase 3 Protocol to Monitor the Neurological Development of Infants With Exposure in Utero From Birth to 15 Months in Tanezumab Clinical Studies Completed
  39. Phase 3 Ibuprofen With or Without Acetaminophen for Low Back Pain Completed
  40. Phase 3 The Effects of Cognitive Behavioral Therapy and Transcranial Current Stimulation (tDCS) on Chronic Lower Back Pain Completed
  41. Phase 3 The Use of Methylsulfonylmethane (MSM) in the Treatment of Low Back Pain Completed
  42. Phase 3 Efficacy and Safety of FIRTECH in Patients With Mild to Moderate Acute Low Back Pain Completed
  43. Phase 3 Study to Evaluate the Safety and Efficacy of ABT-712 in Subjects With Moderate to Severe Chronic Low Back Pain (CLBP) Completed
  44. Phase 3 Buprenorphine Transdermal System (BTDS) in Subjects With Moderate to Severe Chronic Low Back Pain Completed

Showing the 50 most-cited and recently-updated of 223 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Lumbosacral orthoses may improve pain and disability in some patients with chronic non-specific low back pain
Physical Medicine & Rehab Meta-analysis
Lumbosacral orthoses may improve pain and disability in some patients with chronic non-specific low back pain Lumbosacral Orthoses May Help Manage Chronic Low Back Pain
This systematic review of 11 RCTs involving 691 participants examined the effectiveness of various lumbosacral orthoses for chronic non-spec…
New research suggests that wearing a back brace can provide short-term relief from chronic low back pain as part of a broader treatment plan…
Frontiers Jun 8, 2026
Systematic Review and Meta-Analysis: Bariatric Surgery Reduces Low Back Pain in Morbid Obesity
Nutrition & Obesity Medicine Meta-analysis
Systematic Review and Meta-Analysis: Bariatric Surgery Reduces Low Back Pain in Morbid Obesity Metabolic surgery reduces back pain and improves spinal health in morbidly obese adults
This systematic review and meta-analysis of 390 morbidly obese adults found that metabolic and bariatric surgery significantly reduced low b…
Metabolic surgery significantly reduced back pain and improved quality of life for morbidly obese patients with low back pain, though spinal…
May 1, 2026
Meta-analysis shows yoga may improve physical function over exercise for chronic low back pain in adults
Rheumatology Meta-analysis
Meta-analysis shows yoga may improve physical function over exercise for chronic low back pain in adults Yoga Beats Exercise For Back Pain Relief
This systematic review and meta-analysis evaluated seven randomized controlled trials involving adults with non-specific chronic low back pa…
Yoga improves physical function and emotional wellbeing for chronic back pain better than standard exercise programs, offering a unique mind…
Frontiers Apr 14, 2026
Recurrent low back pain accounts for disproportionate healthcare costs in Polish working-age adults
Hematology Cohort
Recurrent low back pain accounts for disproportionate healthcare costs in Polish working-age adults Why Your Back Pain Costs More Than the Pills
A 3-year observational cohort study of working-age adults in Poland found recurrent low back pain cases, comprising 24.5% of all LBP cases, …
Recurring low back pain eats up far more medical services per case than one-time flare-ups, mostly through repeated visits rather than expen…
Frontiers Apr 13, 2026
Systematic review finds limited evidence for antibiotics in low back pain with Modic changes
Geriatrics & Aging Sys. Review
Systematic review finds limited evidence for antibiotics in low back pain with Modic changes Antibiotics Might Ease Back Pain for Some
A systematic review of 3 RCTs (402 adults) found amoxicillin may slightly reduce pain and disability at 12-14 weeks in patients with low bac…
For people with low back pain and specific MRI changes, antibiotics could treat the root cause instead of just masking the pain.
Cochrane Apr 11, 2026
Aquatic therapy versus standard care in 34 patients with chronic low back pain
Psychiatry RCT
Aquatic therapy versus standard care in 34 patients with chronic low back pain Can swimming help chronic back pain? A small study found it might ease pain and fear of movement
This randomized controlled trial evaluated aquatic therapy against standard care in 34 individuals with chronic low back pain over 10 weeks.
Swimming exercises may ease chronic back pain and reduce fear of movement better than standard care alone, helping people break the cycle of…
Apr 9, 2026
Multidomain assessment protocol feasible in secondary care for low back pain
Physical Medicine & Rehab Cohort
Multidomain assessment protocol feasible in secondary care for low back pain Can a better pain check fit into routine care for 542 patients with low back pain?
A proof-of-concept cohort study of 542 patients at a Danish spine center found that embedding a multidomain disability evaluation protocol i…
A new 22-minute pain check using surveys and movement tests fits easily into routine care for patients with low back pain.
Frontiers Apr 8, 2026
Sequenced care pathway not superior to pain navigator for Veterans with low back pain at 3 months
Anesthesiology & Pain Medicine RCT
Sequenced care pathway not superior to pain navigator for Veterans with low back pain at 3 months Two care pathways for Veterans' low back pain showed similar results at three months
A cluster randomized clinical trial of 1817 Veterans with low back pain found that a sequenced care pathway (SCP) was not superior to a pain…
A simpler pain navigator approach worked just as well as a complex program for Veterans with low back pain after three months.
Apr 2, 2026

Questions about Low Back Pain

What evidence exists for using antibiotics in low back pain with Modic changes?

Limited evidence from systematic reviews suggests antibiotics may help some people with low back pain and Modic type 1 changes, but results are uncertain and more research is needed.

Full answer →
Is a sequenced care pathway better than a pain navigator for Veterans with low back pain?

A 2024 trial found that a sequenced care pathway was not superior to a pain navigator for Veterans with low back pain at 3 months.

Full answer →
Does bariatric surgery help reduce low back pain for morbidly obese adults?

Yes, bariatric surgery significantly reduces low back pain in morbidly obese adults, with studies showing major improvements in pain scores and disability.

Full answer →