Cariprazine showed modest weight reduction versus aripiprazole in schizophrenia patients previously treated with olanzapine.
Cariprazine shows modest weight benefit over aripiprazole in schizophrenia patients
This trial compared cariprazine to aripiprazole in patients with schizophrenia who had previously used olanzapine. While both groups improve…
A trial found cariprazine linked to slightly more weight loss than aripiprazole in people with schizophrenia, though overall differences wer…
Mirtazapine and olanzapine reduce anxiety and depression scores in oral cavity cancer patients.
Two Common Pills Ease Cancer Anxiety and Depression
This randomized controlled trial included 144 patients with oral cavity cancer. Both mirtazapine 15 mg/day and olanzapine 5 mg/day significa…
Two well-known antidepressants significantly eased anxiety and depression in oral cancer patients, with mirtazapine showing a slight edge.
Case report review suggests LAI paliperidone stabilizes behavior in a 9-year-old with TBI over two years
Long-acting shots help a boy control severe brain injury rage
This case report review describes a 9-year-old boy with severe traumatic brain injury and posttraumatic confusional state treated with long-…
A boy with severe brain injury rage found calm after months of failed pills, showing long-acting shots could help when daily medicine fails
Non-pharmacological de-escalation techniques used in Australian EDs for children with acute severe behavioural disturbance.
Why Calming Kids in the ER Often Isn’t Enough
This secondary analysis of a randomized controlled trial in 337 children aged 9-17 with acute severe behavioural disturbance found verbal de…
ER staff try talking first for severe behavioral issues, but 96% of children still need medicine to calm down before treatment.
Clozapine, olanzapine, or haloperidol reduced assaults in 99 individuals with schizophrenia and assaultive behaviors.
Does the right antipsychotic drug reduce violence in people with schizophrenia and conduct disorder?
This RCT evaluated clozapine, olanzapine, or haloperidol in 99 individuals with schizophrenia and assaultive behaviors. Reductions in assaul…
Clozapine reduced violent urges in schizophrenia patients even when their mental symptoms did not improve, suggesting a direct calming effec…
Aripiprazole linked to less insight improvement than dopamine antagonists in schizophrenia trial
Can reducing symptoms help people with schizophrenia gain insight into their illness?
A 6-week RCT of 144 schizophrenia spectrum disorder patients found symptom reduction was associated with improved clinical insight. Patients…
Reducing symptoms helps people with schizophrenia gain insight into their illness, but early improvement in hallucinations and delusions mat…
Review synthesizes evidence on olanzapine's metabolic dysregulation and proposes care pathway
How does a common psychiatric medication cause metabolic problems throughout the body?
A systematic review synthesizes clinical and translational evidence on olanzapine's metabolic dysregulation across multiple organs. The revi…
Olanzapine directly injures metabolic systems in multiple organs, causing weight gain and fatty liver disease through mechanisms beyond simp…