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Home › Medications › olanzapine

olanzapine

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of olanzapine

63 trials tracked of olanzapine: 47 in phase 3 or 4 and 15 with published results. The most-cited published study has 449 citations.

63Trials tracked
47Phase 3 & 4
0Recruiting
15With published results
Phase distribution
Phase 4 18 Phase 3 29 Phase 2 10 Other / NA 6
  1. Phase 3 Antiemetic Therapy With or Without Olanzapine in Preventing Chemotherapy-Induced Nausea and Vomiting in Patients With Cancer Receiving Highly Emetogenic Chemotherapy Completed · 449 cited
  2. Phase 3 Aprepitant ,Olanzapine,Palonosetron and Dexamethasone for the Prevention of Chemotherapy-induced Nausea and Vomiting Completed · 251 cited
  3. Phase 4 Metabolic Effects of Antipsychotics in Children Completed · 77 cited
  4. Phase 3 Olanzapine for the Treatment of Chronic Nausea and/or Vomiting in Advanced Cancer Patients Completed · 74 cited
  5. Phase 4 Preventing Relapse in Schizophrenia: Oral Antipsychotics Compared To Injectables: Evaluating Efficacy Completed · 72 cited
  6. Phase 3 Study of FOND Versus FOND+O for the Prevention of CINV in Hematology Patients Receiving Highly Emetogenic Chemotherapy Regimens Completed · 55 cited
Show 44 more trials
  1. Phase 3 A Study of ALKS 3831 in Adults With Acute Exacerbation of Schizophrenia (the ENLIGHTEN-1 Study) Completed · 54 cited
  2. Phase 4 Assessment and Comparison of Metabolic Changes in Non-psychotic Adults Taking Iloperidone or Olanzapine or Placebo Completed · 29 cited
  3. Phase 4 Telmisartan as an Adjunctive Treatment for Metabolic Problems in Patients With Schizophrenia Completed · 27 cited
  4. Phase 3 A Study of ALKS 3831 in Adults With Schizophrenia (The ENLIGHTEN-2 Study) Completed · 24 cited
  5. Phase 4 A Trial to Explore Acceptance and Performance of Using a Digital Medicine System With Healthcare Professionals and Adults With Schizophrenia, Schizoaffective Disorder, or First Episode Psychosis on an Oral Atypical Antipsychotic Completed · 17 cited
  6. Phase 3 Study to Evaluate the Efficacy of ALKS 3831 on Body Weight in Young Adults Who Have Been Recently Diagnosed With Schizophrenia, Schizophreniform, or Bipolar I Disorder Completed · 15 cited
  7. Phase 3 A Study to Compare Disease Progression and Modification Following Treatment With Paliperidone Palmitate Long-Acting Injection or Oral Antipsychotics in Participant's With Recent-onset Schizophrenia or Schizophreniform Completed · 14 cited
  8. Phase 3 Effect of Lu AF35700 in Patients With Treatment-resistant Schizophrenia Completed · 12 cited
  9. Phase 3 Olanzapine With or Without Fosaprepitant Dimeglumine in Preventing Chemotherapy Induced Nausea and Vomiting in Cancer Patients Receiving Highly Emetogenic Chemotherapy Completed · 2 cited
  10. Phase 4 Examining the Effects of Antipsychotic Medications on Insulin Sensitivity Completed
  11. Phase 4 The Effects of Antipsychotic Drugs on Brain Metabolism in Healthy Individuals Completed
  12. Phase 4 Safety Study of Olanzapine and a Comparator in Patients With Schizophrenia and Schizoaffective Disorder Completed
  13. Phase 4 A Comparison of Olanzapine in Combination With a Mood Stabilizer vs Mood Stabilizer Alone, in Mixed Bipolar Patients Completed
  14. Phase 4 Effectiveness of Atypical Antipsychotic Medication for Outpatients With Anorexia Nervosa Completed
  15. Phase 4 15 Month Study for Adults Who Have Been Diagnosed With Schizophrenia and Incarcerated Completed
  16. Phase 4 Comparison of Optimal Antipsychotic Treatments for Adults With Schizophrenia Completed
  17. Phase 4 Supported Employment and Skills Training in Conjunction With Pharmacotherapy in Schizophrenia Patients Completed
  18. Phase 4 Study in Adolescents With Schizophrenia or Bipolar Disorder Completed
  19. Phase 4 Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders Completed
  20. Phase 4 Comparison of Antipsychotics for Metabolic Problems in Schizophrenia or Schizoaffective Disorder Completed
  21. Phase 4 Efficacy Study of Early Onset of Antipsychotic Drug Action in Schizophrenia Completed
  22. Phase 4 Switching Medication to Treat Schizophrenia Completed
  23. Phase 3 Treatment of Refractory Nausea and Vomiting in Patients With Breast Cancer Completed
  24. Phase 3 Efficacy and Safety of Olanzapine in the Extended Treatment for Manic or Mixed Episode of Bipolar I Disorder Completed
  25. Phase 3 A Study of the Efficacy and Safety of Asenapine in Participants With an Acute Exacerbation of Schizophrenia (P05688) Completed
  26. Phase 3 Efficacy and Safety of Asenapine Compared With Olanzapine in Patients With Persistent Negative Symptoms of Schizophrenia (A7501013)(COMPLETED)(P05771) Completed
  27. Phase 3 A Study to Evaluate Effectiveness and Safety of ER OROS Paliperidone in Patients With Schizophrenia Completed
  28. Phase 3 Olanzapine Pamoate Depot Versus Oral Olanzapine on Treatment Outcomes in Outpatients With Schizophrenia Completed
  29. Phase 3 Trial of Olanzapine in Patients With Manic or Mixed Episode of Bipolar I Disorder Completed
  30. Phase 3 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptoms Patients Who Completed the First 6- Month Trial (A7501014)(COMPLETED)(P05772) Completed
  31. Phase 3 A Study to Evaluate the Effectiveness and Safety of Extended-Release (ER) Paliperidone Compared With Placebo in Delaying the Recurrence of Symptoms in Bipolar I Disorder Completed
  32. Phase 3 Validation of Multidimensional Assessment of THYmic States (MATHYS): A Study in a Population of Bipolar Patients Treated With Olanzapine Completed
  33. Phase 3 Study of Pharmacotherapy of Psychotic Depression Completed
  34. Phase 3 A 6 Month Study to Compare the Metabolic Effects of Paliperidone ER and Olanzapine in Patients With Schizophrenia Completed
  35. Phase 3 Olanzapine Treatment of Patients With Bipolar I Disorder Completed
  36. Phase 3 A Study to Evaluate the Efficacy and Safety of Risperidone for the Prevention of Mood Episodes in the Treatment of Patients With Bipolar I Disorder Completed
  37. Phase 3 Safety and Efficacy of Olanzapine in the Long-term Treatment for Bipolar I Disorder, Depressed Completed
  38. Phase 3 6-Month Extension Trial of Asenapine With Olanzapine in Negative Symptom Patients Who Completed the Protocol 25543 (25544)(P05777) Completed
  39. Phase 3 Lurasidone HCl A Phase 3 Study of Patients With Acute Schizophrenia Completed
  40. Phase 3 Assessment of Safety and Efficacy of Therapy for the Prevention of Weight Gain Associated With Olanzapine Completed
  41. Phase 3 40 Week Extension Study Of Asenapine and Olanzapine For Bipolar Disorder (A7501007)(COMPLETED)(P05857) Completed
  42. Phase 2 Diabetes in Neuropsychiatric Disorders Completed
  43. Phase 2 Phase IIA Study in Patients With Schizophrenia Completed
  44. Phase 2 Olanzapine for Prevention of Chemotherapy-induced Nausea and Vomiting in Children: A Multi-Centre Feasibility Study Completed

Showing the 50 most-cited and recently-updated of 63 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Cariprazine showed modest weight reduction versus aripiprazole in schizophrenia patients previously treated with olanzapine
Psychiatry RCT
Cariprazine showed modest weight reduction versus aripiprazole in schizophrenia patients previously treated with olanzapine Cariprazine shows modest weight benefit over aripiprazole in schizophrenia patients
This trial compared cariprazine to aripiprazole in patients with schizophrenia who had previously used olanzapine.
A trial found cariprazine linked to slightly more weight loss than aripiprazole in people with schizophrenia, though overall differences wer…
May 1, 2026
Mirtazapine and olanzapine reduce anxiety and depression scores in oral cavity cancer patients
Oncology RCT
Mirtazapine and olanzapine reduce anxiety and depression scores in oral cavity cancer patients Two Common Pills Ease Cancer Anxiety and Depression
This randomized controlled trial included 144 patients with oral cavity cancer.
Two well-known antidepressants significantly eased anxiety and depression in oral cancer patients, with mirtazapine showing a slight edge.
Apr 29, 2026
Case report review suggests LAI paliperidone stabilizes behavior in a 9-year-old with TBI over two years
Psychiatry Sys. Review
Case report review suggests LAI paliperidone stabilizes behavior in a 9-year-old with TBI over two years Long-acting shots help a boy control severe brain injury rage
This case report review describes a 9-year-old boy with severe traumatic brain injury and posttraumatic confusional state treated with long-…
A boy with severe brain injury rage found calm after months of failed pills, showing long-acting shots could help when daily medicine fails
Frontiers Apr 29, 2026
Non-pharmacological de-escalation techniques used in Australian EDs for children with acute severe behavioural disturbance
Pediatrics RCT
Non-pharmacological de-escalation techniques used in Australian EDs for children with acute severe behavioural disturbance Why Calming Kids in the ER Often Isn’t Enough
This secondary analysis of a randomized controlled trial in 337 children aged 9-17 with acute severe behavioural disturbance found verbal de…
ER staff try talking first for severe behavioral issues, but 96% of children still need medicine to calm down before treatment.
Apr 19, 2026
Clozapine, olanzapine, or haloperidol reduced assaults in 99 individuals with schizophrenia and assaultive behaviors
Psychiatry RCT
Clozapine, olanzapine, or haloperidol reduced assaults in 99 individuals with schizophrenia and assaultive behaviors Does the right antipsychotic drug reduce violence in people with schizophrenia and conduct disorder?
This RCT evaluated clozapine, olanzapine, or haloperidol in 99 individuals with schizophrenia and assaultive behaviors.
Clozapine reduced violent urges in schizophrenia patients even when their mental symptoms did not improve, suggesting a direct calming effec…
Apr 9, 2026
Aripiprazole linked to less insight improvement than dopamine antagonists in schizophrenia trial
Psychiatry RCT
Aripiprazole linked to less insight improvement than dopamine antagonists in schizophrenia trial Can reducing symptoms help people with schizophrenia gain insight into their illness?
A 6-week RCT of 144 schizophrenia spectrum disorder patients found symptom reduction was associated with improved clinical insight.
Reducing symptoms helps people with schizophrenia gain insight into their illness, but early improvement in hallucinations and delusions mat…
Apr 7, 2026
Review synthesizes evidence on olanzapine's metabolic dysregulation and proposes care pathway
Drug Pipeline Sys. Review
Review synthesizes evidence on olanzapine's metabolic dysregulation and proposes care pathway How does a common psychiatric medication cause metabolic problems throughout the body?
A systematic review synthesizes clinical and translational evidence on olanzapine's metabolic dysregulation across multiple organs.
Olanzapine directly injures metabolic systems in multiple organs, causing weight gain and fatty liver disease through mechanisms beyond simp…
Frontiers Apr 2, 2026