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Chemotherapy-Induced Nausea and Vomiting

6 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Chemotherapy-Induced Nausea and Vomiting

39 trials tracked for Chemotherapy-Induced Nausea and Vomiting: 19 in phase 3 or 4 and 6 with published results. The most-cited published study has 251 citations.

39Trials tracked
19Phase 3 & 4
0Recruiting
6With published results
Phase distribution
Phase 4 2 Phase 3 17 Phase 2 10 Phase 1 4 Other / NA 6
  1. Phase 3 Aprepitant ,Olanzapine,Palonosetron and Dexamethasone for the Prevention of Chemotherapy-induced Nausea and Vomiting Completed · 251 cited
  2. Phase 3 A Safety Study of Intravenous Pro-Netupitant and Palonosetron Combination for the Prevention of Nausea and Vomiting Completed · 39 cited
  3. Phase 3 A Study Of IV Casopitant For The Prevention Of Chemotherapy Induced Nausea And Vomiting. Completed · 32 cited
  4. Phase 3 A Prospective, Multicenter, Study of APF530 (Granisetron) SC for Prevention of CINV in Patients Receiving HEC Completed · 24 cited
  5. Phase 3 A Study to Assess the Safety and the Efficacy of IV Fosnetupitant/Palonosetron (260 mg/0.25 mg) Combination Compared to Oral Netupitant/Palonosetron (300 mg/0.5 mg) Combination for the Prevention of CINV in AC Chemotherapy in Women With Breast Cancer Completed · 14 cited
  6. Phase 4 Safety of a Three-Day Fosaprepitant Regimen for the Prevention of Chemotherapy-Induced Nausea and Vomiting in Pediatric Participants (MK-0517-045) Completed
Show 33 more trials
  1. Phase 4 Oral Akynzeo® vs Standard of Care in Preventing CINV in High-risk MEC Patients (MyRisk) Completed
  2. Phase 3 An Efficacy and Safety Study of Intravenous Palonosetron Administered as an Infusion and as a Bolus for the Prevention of Nausea and Vomiting Completed
  3. Phase 3 Palonosetron and Dexamethasone With or Without Dronabinol in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy For Cancer Completed
  4. Phase 3 Olanzapine for Nausea/Vomiting Prophylaxis in Recipients of Hematopoietic Stem Cell Transplants Completed
  5. Phase 3 Efficacy and Safety of Palonosetron Intravenous in Prevention of Chemotherapy Induced Nausea and Vomiting in Pediatric Patients Completed
  6. Phase 3 A Safety Study of Oral Netupitant and Palonosetron for the Prevention of Nausea and Vomiting Completed
  7. Phase 3 Ph 3 Safety/Efficacy Study of Rolapitant for Prevention of CINV in Subjects Receiving Moderately Emetogenic Chemotherapy Completed
  8. Phase 3 An Efficacy and Safety Study of Oral Netupitant and Palonosetron for the Prevention of Nausea and Vomiting Completed
  9. Phase 3 Aprepitant for the Prevention of Chemotherapy Induced Nausea and Vomiting (CINV)(0869-130)(COMPLETED) Completed
  10. Phase 3 Ph3 Safety/Efficacy Study of Rolapitant for the Prevention of CINV in Subjects Receiving Highly Emetogenic Chemotherapy Completed
  11. Phase 3 A Study of the Safety and Efficacy of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Pediatric Participants (MK-0869-208) Completed
  12. Phase 3 Ph3 Safety/Efficacy Study of Rolapitant for the Prevention of CINV in Subjects Receiving Highly Emetogenic Chemotherapy Completed
  13. Phase 3 An Efficacy and Safety Study of Oral and Intravenous Palonosetron for the Prevention of Nausea and Vomiting Completed
  14. Phase 2 Palonosetron, Ondansetron, and Dexamethasone for Delayed Nausea and Vomiting in Autologous Transplant Patients Completed
  15. Phase 2 Olanzapine for Prevention of Chemotherapy-induced Nausea and Vomiting in Children: A Multi-Centre Feasibility Study Completed
  16. Phase 2 Aromatherapy for Chemotherapy-induced Nausea and Vomiting (CINV) Completed
  17. Phase 2 Pilot Study of Olanzapine and Aprepitant to Prevent Nausea and Vomiting in Children Receiving Chemotherapy Completed
  18. Phase 2 Phase 2 Study of Efficacy, Tolerability, and Safety of Intranasal Granisetron for Chemo-Induced Nausea and Vomiting Completed
  19. Phase 2 Palonosetron Versus Ondansetron for the Prevention of Nausea and Vomiting Completed
  20. Phase 2 Study of the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Fosaprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Children (MK-0517-029) Completed
  21. Phase 2 Fosaprepitant + 5HT3 Receptor Antagonists + Dexamethasone in Germ Cell Tumors Completed
  22. Phase 2 Safety and Efficacy of Aprepitant, Ramosetron, and Dexamethasone for Chemotherapy-Induced Nausea and Vomiting in Patients With Ovarian Cancer Treated With Taxane/Carboplatin Completed
  23. Phase 2 Use of Aromatherapy to Reduce Symptom Burden Completed
  24. Phase 1 A Study to Assess the Bioequivalence of Aprepitant and Fosaprepitant and the Effect of Food on Aprepitant Bioavailability (0869-165) Completed
  25. Phase 1 A Bioequivalence Study of 3 Formulations of Ondansetron in Healthy Adults (0869-095)(COMPLETED) Completed
  26. Phase 1 A Study to Investigate the Safety and Tolerability of MK-0517 in Healthy Subjects (MK-0517-012) Completed
  27. Phase 1 Bioequivalence of Two Formulations of Ondansetron in Healthy Adults (0869-106) Completed
  28. N/A Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed
  29. N/A Acupuncture for Chemotherapy-Induced Nausea and Vomiting Completed
  30. N/A Observational Study on the Use of Akynzeo® in Patients Receiving HEC Completed
  31. N/A Re-examination Study of EMEND (Aprepitant) (MK-0869-184) Completed
  32. N/A Fosaprepitant in Patients Receiving Ifosfamide-based Regimen Completed
  33. N/A Promoting Cancer Symptom Management in Older Adults Completed

Showing the 39 most-cited and recently-updated of 39 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Questions about Chemotherapy-Induced Nausea and Vomiting

What risk factors are associated with chemotherapy-induced nausea and vomiting in breast cancer?

Key risk factors for CINV in breast cancer include younger age (≤45 years), history of motion sickness, and multiple chemotherapy cycles (≥3).

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Can Focinvez prevent chemotherapy-induced nausea and vomiting in cancer patients?

Yes, Focinvez (fosaprepitant) is FDA-approved to prevent chemotherapy-induced nausea and vomiting when used with other antiemetics.

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How do 5-HT3 antagonists compare to dexamethasone for highly emetogenic chemotherapy-induced nausea and vomiting?

5-HT3 antagonists and dexamethasone are both effective for CINV, but adding a 5-HT3 antagonist to dexamethasone improves outcomes; guidelines recommend using them together with other agents for highly emetogenic chemotherapy.

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How common is chemotherapy-induced nausea and vomiting in breast cancer patients?

About 48% of breast cancer patients experience chemotherapy-induced nausea and vomiting, with higher risk in younger patients and those with motion sickness history.

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