HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Psychiatry
Meta-analysis
fMRI shows decreased activation in anterior cingulate cortex and increased activation in amygdala in women with premenstrual dysphoric disorder
Brain scans show PMDD linked to distinct activity patterns
This systematic review examined functional brain alterations in 598 participants, including 294 PMDD patients and 304 healthy controls. Wome…
Brain scans of women with PMDD show different activity in emotion and pain areas compared to healthy women, a review finds.
Frontiers
Jun 4, 2026
Psychiatry
Meta-analysis
Systematic review finds no efficacy advantage for psychedelic-assisted therapy over traditional antidepressants in major depression
A large review found that psychedelic therapy did not work better than standard antidepressant pills for depression
This systematic review and meta-analysis evaluated psychedelic-assisted therapy versus traditional antidepressants for major depression in a…
A massive study looked at psychedelic therapy versus regular antidepressants. It found that standard pills worked just as well or better for…
May 6, 2026
Psychiatry
RCT
Adjunctive JNJ-42165279 fails to improve depression in SSRI/SNRI inadequate responders
Early trial finds new drug did not help depression in patients already on antidepressants
This phase 2a double-blind RCT tested adjunctive JNJ-42165279 25 mg daily versus placebo in 153 adults with major depressive disorder with a…
A small early study found a new drug did not improve depression symptoms for patients already taking standard antidepressants.
May 1, 2026
Nutrition & Obesity Medicine
Meta-analysis
Umbrella review identifies risk factors and protective factors for male infertility and semen quality
New study lists many things that hurt male fertility and health
This umbrella review of 43 studies synthesizes evidence on risk factors for male infertility and abnormal semen parameters.
A new review shows that obesity, smoking, and certain illnesses can hurt sperm, but healthy habits might fix the problem.
May 1, 2026
Drug Pipeline
Sys. Review
Systematic review of Traditional Chinese Medicine for depression with unreported outcomes and safety data
Ancient Herbs Show Promise for Hard-to-Treat Depression
This systematic review evaluates Traditional Chinese Medicine (TCM), including botanical drug formulas, single medicinal botanical drugs, an…
Scientists are finding that traditional herbal blends might help where modern pills fall short.
Frontiers
Apr 24, 2026