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Home › Medications › sertraline

sertraline

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of sertraline

56 trials tracked of sertraline: 34 in phase 3 or 4 and 16 with published results. The most-cited published study has 153 citations.

56Trials tracked
34Phase 3 & 4
0Recruiting
16With published results
Phase distribution
Phase 4 18 Phase 3 16 Phase 2 11 Phase 1 2 Other / NA 9
  1. Phase 3 Treatments for Depression: Drug Versus Psychotherapy Completed · 153 cited
  2. Phase 3 Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis Completed · 127 cited
  3. Phase 3 Chronic Kidney Disease Antidepressant Sertraline Trial Completed · 124 cited
  4. Phase 3 Comparison of Two Treatments for Post-Traumatic Stress Disorder Completed · 122 cited
  5. Phase 3 Rhodiola Rosea Therapy of Major Depressive Disorder Completed · 110 cited
  6. Phase 4 Treatment of Diabetes and Depression in Hispanics and African Americans and Its Effect on A1c and Quality of Life. Completed · 97 cited
Show 44 more trials
  1. Phase 4 Evaluating the Effectiveness of Sertraline in Treating Women With Premenstrual Dysphoric Disorder Completed · 87 cited
  2. Phase 4 PROlonGed ExpoSure Sertraline Completed · 40 cited
  3. Phase 3 A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major Depressive Disorder Completed · 25 cited
  4. Phase 4 Stress & Premenstrual Symptoms Study Completed · 17 cited
  5. Phase 3 Brexpiprazole as Combination Therapy With Sertraline in Treatment of Adults With PTSD Completed · 13 cited
  6. Phase 3 Safety and Tolerability of Oral OPC-34712 as Adjunctive Therapy in Adults With Major Depressive Disorder (the Orion Trial) Completed · 13 cited
  7. Phase 4 A Pilot Trial of Perinatal Depression Treatment in HIV Infected Women Completed · 12 cited
  8. Phase 4 Cost- Effectiveness and Quality of Life Assessment in Bipolar Disorder Depressive Episode Completed · 6 cited
  9. Phase 4 Cost- Effectiveness and Quality of Life Assessment in Major Depression Disorder Completed · 6 cited
  10. Phase 3 Brexpiprazole as Combination Therapy With Sertraline in the Treatment of Adults With Post-traumatic Stress Disorder Completed
  11. Phase 4 Frontal Hypoperfusion Effects on Antidepressant Outcomes in Late-Life Depression Completed
  12. Phase 4 Serotonin Selective Reuptake Inhibitor Treatment of Dual Diagnosis Post-traumatic Stress Disorder and Alcohol Problems Completed
  13. Phase 4 Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight Completed
  14. Phase 4 A Study Comparing Duloxetine to Other Antidepressants in the Treatment of Severe Depression Completed
  15. Phase 4 A Study of Sertraline to Prevent PTSD Completed
  16. Phase 4 Sertraline Pharmacotherapy for Alcoholism Subtypes Completed
  17. Phase 4 Improving Treatment Outcomes in Pharmacotherapy of Generalized Social Anxiety Disorder Completed
  18. Phase 4 Treatments for Psychogenic Nonepileptic Seizures (NES) Completed
  19. Phase 4 Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial Completed
  20. Phase 4 Antidepressant Treatment of Melancholia in Late Life Completed
  21. Phase 4 A Study Of Sertraline Compared With Paroxetine In The Treatment Of Panic Disorder Completed
  22. Phase 3 Antidepressant Medication Treatment for Depression in Individuals With Chronic Heart Failure Completed
  23. Phase 3 Quetiapine XR Versus Sertraline in Acute Bipolar Depression as add-on Therapy Completed
  24. Phase 3 Study of Pharmacotherapy of Psychotic Depression Completed
  25. Phase 3 Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury Completed
  26. Phase 3 Ziprasidone vs. Sertraline/Haloperidol in Psychotic Depression Completed
  27. Phase 3 Therapies for Treatment-Resistant Panic Disorder Symptoms Completed
  28. Phase 3 Exercise to Treat Depression in Individuals With Coronary Heart Disease Completed
  29. Phase 2 A Trial of Sertraline in Young Children With Autism Spectrum Disorder Completed
  30. Phase 2 A Study of Flexible Dose Brexpiprazole as Monotherapy or Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder (PTSD) Completed
  31. Phase 2 Geodon for the Treatment of Refractory Social Anxiety Disorder Completed
  32. Phase 2 Trial of Sertraline to Treat Children With Fragile X Syndrome Completed
  33. Phase 2 Effectiveness of Sertraline Alone and Interpersonal Psychotherapy Alone in Treating Women With Postpartum Depression Completed
  34. Phase 2 Effects of Sertraline on Brain Connectivity in Adolescents With OCD Completed
  35. Phase 2 Combined Treatment for Alcohol-Dependent Individuals With PTSD Completed
  36. Phase 2 The Serotonin Transporter Availability for Prognosing Major Depressive Disorder (MDD) Treatment and Detecting MDD Completed
  37. Phase 2 Treatment of Post-Traumatic Brain Injury (TBI) Depression Completed
  38. Phase 2 Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care for Depression Completed
  39. Phase 2 Clinical Efficacy of Sertraline Augmented With Gabapentin in Depressed, Recently Abstinent Cocaine-dependent Humans Completed
  40. Phase 1 A Study Comparing the Drug Exposure in Humans After Administration of a 50 mg Tablet of Sertraline Hydrochloride as Compared to a 50 mg Capsule of Sertraline Hydrochloride Under Fasted (Nonfed) Conditions Completed
  41. Phase 1 A Pharmacokinetic Study of the Coadministration of LY2216684 With Sertraline Completed
  42. N/A Special Investigation Of Long Term Use Of Sertraline. Completed
  43. N/A fMRI Study of Treatment Changes in Major Depression Completed
  44. N/A Magnetic Resonance Imaging Study of Geriatric Depression Completed

Showing the 50 most-cited and recently-updated of 56 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Preliminary evidence suggests therapeutic drug monitoring of sertraline may guide clinical judgment in specific populations
Drug Pipeline Meta-analysis
Preliminary evidence suggests therapeutic drug monitoring of sertraline may guide clinical judgment in specific populations TDM Monitoring May Help Guide Sertraline Use for OCD Patients
This scoping review examined the clinical utility of sertraline therapeutic drug monitoring (TDM) for individuals with depression and obsess…
Monitoring blood levels of the medication sertraline might help doctors manage treatment for patients with depression and obsessive-compulsi…
Frontiers Jul 25, 2026
Fatal serotonin syndrome in Parkinson's patient on rasagiline after sequential SSRI administration
Psychiatry
Fatal serotonin syndrome in Parkinson's patient on rasagiline after sequential SSRI administration Case report describes fatal serotonin syndrome in older Parkinson's patient on multiple medications
A case report describes a 72-year-old Parkinson's patient on rasagiline who developed fatal serotonin syndrome after sequential sertraline a…
A 72-year-old Parkinson's patient died after taking two antidepressants with a genetic makeup that slowed drug processing, causing fatal ser…
Frontiers Apr 1, 2026