Sirolimus and paclitaxel-coated balloons show similar outcomes for coronary in-stent restenosis
Sirolimus and paclitaxel balloons show similar results for heart disease
This GRADE-assessed systematic review and meta-analysis of 3,633 participants with coronary artery disease found no notable variations betwe…
Two drug-coated balloons for coronary artery disease work about equally well, a new analysis finds.
Systematic review and meta-analysis of drug-coated balloons versus drug-eluting stents in coronary artery disease
Meta-analysis links drug balloons to higher heart risks
This systematic review and meta-analysis evaluated drug-coated balloons (DCB) versus drug-eluting stents (DES) in 8,123 patients with corona…
A review of 8,123 patients found drug-coated balloons for heart arteries may raise risks of repeat procedures and cardiac death compared to …
Review of preclinical interventions for heat stroke pathophysiology and gaps
Heat Stroke Harms Your Cells: New Clues Could Change Treatment
This narrative review synthesizes preclinical evidence on several compounds for heat stroke pathophysiology. The authors note mitochondrial …
Heat stroke doesn't just raise your temperature, it shuts down your cells' power plants, and new research points to ways of protecting them …
Meta-analysis of sirolimus for cutaneous squamous cell carcinoma in kidney transplant recipients
Sirolimus lowers skin cancer risk in kidney transplant patients
This meta-analysis of four randomized trials in kidney transplant recipients with prior cutaneous squamous cell carcinoma found that switchi…
A review of studies shows switching to sirolimus can cut skin cancer rates, but it may cause more side effects.
Paclitaxel-coated balloons and sirolimus-eluting stents in noncomplex coronary bifurcation lesions
Drug coated balloons show similar results for certain artery blockages
This randomized noninferiority trial subgroup analysis evaluated 2,257 participants with de novo coronary lesions.
New data suggests drug coated balloons may work as well as traditional stents for specific types of coronary artery blockages.
Sirolimus-eluting iron bioresorbable scaffold shows higher late lumen loss than everolimus-eluting stents in coronary artery disease patients
New iron scaffold matches metal stents for heart artery repair
This randomized trial enrolled 518 patients with myocardial ischemia and 1 or 2 de novo target lesions at 36 centers in China.
A new iron heart scaffold matches metal stents in safety and effectiveness while dissolving over time.
Computational model review predicts dual optima for combination therapy in ageing
New math model shows combining drugs could slow aging better than weight loss alone
This review of a computational model explores combination therapy with semaglutide, SGLT2 inhibitors, metformin, and rapamycin for ageing.
A new computer model reveals that fixing blood sugar and slowing aging are separate tasks, meaning some drugs might help you live longer eve…
High NSUN3 expression linked to poor survival in oral squamous cell carcinoma
High NSUN3 protein makes oral cancer spread faster
This cohort study of 60 oral squamous cell carcinoma patients found that upregulated NSUN3 expression is an independent risk factor for poor…
Imagine waking up with a sore in your mouth that won't heal.
Proteomic profiling in anti-VEGF-treated AMD patients reveals VEGF-independent immune pathway activation
Why Immune Cells Keep Damaging Your Eyes
This observational study analyzed vitreous proteomic profiles in eight patients with neovascular AMD receiving anti-VEGF therapy compared to…
Standard eye drops for AMD stop one problem, but a second, hidden immune attack is still hurting your vision.
Itacitinib plus standard therapy in acute leukemia or myelofibrosis patients undergoing reduced-intensity conditioning donor stem cell transplantation
Early trial explores itacitinib for stem cell transplant patients with blood disorders
This Phase IIa trial evaluated itacitinib combined with tacrolimus and sirolimus in patients with acute leukemia, myelodysplastic syndrome, …
A new trial adds itacitinib to standard care for stem cell transplant patients with blood disorders to help prevent graft-versus-host diseas…
Rapamycin therapy reduced infections and lymph node size in a female child with APDS1
Neck Mass Was Not Cancer, It Was This Rare Condition
This case report describes a single female patient with Activated phosphoinositide 3-kinase delta syndrome type I (APDS1) who received rapam…
A rare genetic immune disorder caused a neck mass mistaken for cancer, ending years of failed treatments for recurrent lung infections and s…
Emergency sclerotherapy resolves airway obstruction in neonates with giant head and neck lymphatic malformations
A Simple Procedure Saves Newborns Struggling to Breathe
A retrospective cohort study of 13 neonates with giant head and neck lymphatic malformations complicated by airway obstruction found that em…
Doctors have refined a life-saving technique that can relieve a newborn’s airway obstruction in days, preventing the need for risky surgery.