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Home › Conditions › Squamous Cell Carcinoma

Squamous Cell Carcinoma

Part of Cancer

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Squamous Cell Carcinoma

46 trials tracked for Squamous Cell Carcinoma: 7 in phase 3 or 4 and 1 with published results. The most-cited published study has 22 citations.

46Trials tracked
7Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 3 4 Phase 2 25 Phase 1 4 Other / NA 10
  1. Phase 4 CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial Completed · 22 cited
  2. Phase 4 Safety and Efficacy Study of Abraxane in Combination With Carboplatin to Treat Advanced NSCL Cancer in the Elderly Completed
  3. Phase 4 Post-Operative Drainage Following Lymph Node Dissection Completed
  4. Phase 3 Photodynamic Therapy (PDT) With Metvix® 160 Milligrams/Gram Cream in Organ Transplant Participants With Non-melanoma Skin Cancer Completed
  5. Phase 3 Pembrolizumab (MK-3475) Versus Placebo Following Surgery and Radiation in Participants With Locally Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630/KEYNOTE-630) Completed
  6. Phase 3 LUX-Head&Neck 1: A Phase III Trial of Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy Completed
Show 40 more trials
  1. Phase 3 Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer Completed
  2. Phase 2 Cetuximab and Lenalidomide in Head and Neck Completed
  3. Phase 2 De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell Ca Completed
  4. Phase 2 Radiotherapy Plus Panitumumab Compared to Chemoradiotherapy With Unresected, Locally Advanced Squamous Cell Carcinoma of the Head and Neck Completed
  5. Phase 2 De-Escalation Therapy for Human Papillomavirus Negative Disease Completed
  6. Phase 2 A Phase II Trial of Cetuximab and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer Completed
  7. Phase 2 De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up Study Completed
  8. Phase 2 PRISM (Panitumumab Regimen In Second-line Monotherapy of Head and Neck Cancer) Completed
  9. Phase 2 Erlotinib in Women With Squamous Cell Carcinoma of the Vulvar Completed
  10. Phase 2 Quercetin Chemoprevention for Squamous Cell Carcinoma in Patients With Fanconi Anemia Completed
  11. Phase 2 Capecitabine or 5-FU With Pegylated Interferon Alpha-2b in Unresectable/Metastatic Cutaneous Squamous Cell Carcinoma Completed
  12. Phase 2 Study of Addition of Panitumumab to Chemoradiation Therapy in Patients With Locally Advanced Head and Neck Cancer Completed
  13. Phase 2 Radiation and Cetuximab Plus Intratumoral EGFR Antisense DNA in Locally Advanced Head and Neck Squamous Cell Carcinoma Completed
  14. Phase 2 Neoadjuvant Chemotherapy Versus Radiochemotherapy for Cancer of the Esophagus or Cardia Completed
  15. Phase 2 P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCC Completed
  16. Phase 2 A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6 Completed
  17. Phase 2 Study of TVEC in Patients With Cutaneous Squamous Cell Cancer Completed
  18. Phase 2 Paclitaxel, Carboplatin and Radiotherapy as Induction Therapy in Locally Advanced Head and Neck Cancer Completed
  19. Phase 2 BIBW 2992 (Afatinib) in Head & Neck Cancer Completed
  20. Phase 2 Rapamycin Therapy in Head and Neck Squamous Cell Carcinoma Completed
  21. Phase 2 Study of Pembrolizumab (MK-3475) in Adults With Recurrent/Metastatic Cutaneous Squamous Cell Carcinoma (cSCC) or Locally Advanced Unresectable cSCC (MK-3475-629/KEYNOTE-629) Completed
  22. Phase 2 Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers Completed
  23. Phase 2 An Open-Label Safety Study of API 31510 in a Topical Cream for in Situ Cutaneous Squamous Cell Carcinoma (SCCIS) Completed
  24. Phase 2 Cetuximab in Head and Neck Cancer Patients Completed
  25. Phase 2 Involved Field Elective Volume De-Intensification Radiation Therapy for Head and Neck Cancer Completed
  26. Phase 2 Determine Tumor Response Using Fluorodeoxyglucose (FDG)- Positron Emission Tomography (PET)/Computed Tomography (CT) Before and After Cetuximab in Patients With Head and Neck Cancer Completed
  27. Phase 1 M6620 Plus Standard Treatment in Oesophageal and Other Cancer Completed
  28. Phase 1 Nivolumab and Tumor Infiltrating Lymphocytes (TIL) in Advanced Non-Small Cell Lung Cancer Completed
  29. Phase 1 Pembrolizumab in Combination With CRT for LA-SCCHN Completed
  30. Phase 1 Testosterone for Treating Cachexia in Patients With Squamous Cell Carcinoma Completed
  31. N/A Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo Completed
  32. N/A Serum Concentration of Lidocaine After Local Injection During Mohs Micrographic Surgery Completed
  33. N/A Safety and Efficacy of Oral Midazolam for Perioperative Anxiety Relief of Patients Undergoing Mohs Micrographic Surgery Completed
  34. N/A Absorbable Suture Versus Tissue Glue to Repair Defects Following Mohs Surgery Completed
  35. N/A Strategies to Promote Skin Health Completed
  36. N/A The Impact of Total Body Skin Examination on Skin Cancer Detection Completed
  37. N/A Correlation Between Skin Carotenoid Levels and Previous History of Skin Cancer Completed
  38. N/A Warning Signs of Squamous Cell Carcinoma and Prevention of SCC by at Risk Organ Transplant Recipients Completed
  39. N/A Using MC1R Genotype to Impact Melanoma Risk Behavior Completed
  40. N/A Observational Study of Incidence Rates of Esophageal Cancer in Women Taking Medications for the Prevention or Treatment of Osteoporosis (MK-0217A-352) Completed

Showing the 46 most-cited and recently-updated of 46 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Squamous Cell Carcinoma: what the trials found

New evidence indicates that Quercetin, a dietary supplement, is being investigated in Phase 2 trials for Squamous Cell Carcinoma 1.

Treatment with 5-fluorouracil showed no statistically significant difference in the time to diagnosis of the first keratinocyte carcinoma (KC) requiring surgery or the hazard ratio for surgically treated KC 2. Nab-paclitaxel was associated with high rates of grade 2 or higher peripheral neuropathy and grade 3 or higher myelosuppression (approximately 76-77%) 3, with over half of patients requiring dose reductions 3.

Photodynamic therapy using Metvix 160 mg/g cream showed a significant reduction in the number of accumulated new skin lesions at month 3 compared to control 6, though this difference did not reach statistical significance at months 9 or 15 6. Afatinib demonstrated a statistically significant improvement in progression-free survival (PFS) but did not show a statistically significant difference in overall survival (OS) or objective response (OR) 7.

In studies involving placebo, there were significant differences in the incidence, duration, and time to onset of severe (Grade 3 or 4) oral mucositis 8. Clinical management with chemotherapy was evaluated across multiple trials [16, 19], and Pembrolizumab was assessed in Phase 2 settings 17.

The use of Fibrin Sealant (Tisseel) showed no statistically significant differences in post-operative wound drainage, length of time drains remained in situ, or the number of patients with post-operative complications 4.

Recent results — preliminary, needs further review

  • Quercetin (dietary supplement) is currently under investigation in Phase 2 trials 1.

For the clinician treating this condition

  • Afatinib has been shown to improve progression-free survival (PFS) in patients with Squamous Cell Carcinoma, though it did not significantly impact overall survival 7.
  • Photodynamic therapy with Metvix 160 mg/g cream shows a significant reduction in new skin lesions at the 3-month mark 6.
  • Nab-paclitaxel is associated with high rates of peripheral neuropathy and myelosuppression, necessitating frequent dose monitoring 3.

AI synthesis of 8 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Actinic keratosis increases melanoma risk while alcohol consumption is associated with lower squamous cell carcinoma risk
Genetics & Precision Medicine Meta-analysis
Actinic keratosis increases melanoma risk while alcohol consumption is associated with lower squamous cell carcinoma risk Actinic Keratosis Linked to Higher Risk of Melanoma
This meta-analysis of genome-wide association studies evaluates causal relationships between 11 modifiable risk factors and skin cancers. Th…
New research identifies a link between actinic keratosis and melanoma risk while highlighting potential new targets for skin cancer treatmen…
Frontiers Jul 8, 2026
Sugar sweetened beverages and orange juice are associated with increased risk of several cancer types
Nutrition & Obesity Medicine Sys. Review
Sugar sweetened beverages and orange juice are associated with increased risk of several cancer types Sugar sweetened drinks may increase risk of several cancer types
This meta-analysis of 51 cohort studies evaluates the link between sugar sweetened beverages (SSBs), artificially sweetened beverages (ASBs)…
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Meta-analysis of sirolimus for cutaneous squamous cell carcinoma in kidney transplant recipients
Dermatology Meta-analysis
Meta-analysis of sirolimus for cutaneous squamous cell carcinoma in kidney transplant recipients Sirolimus lowers skin cancer risk in kidney transplant patients
This meta-analysis of four randomized trials in kidney transplant recipients with prior cutaneous squamous cell carcinoma found that switchi…
A review of studies shows switching to sirolimus can cut skin cancer rates, but it may cause more side effects.
May 2, 2026
Becotatug vedotin shows 20.9% objective response in recurrent head and neck squamous cell carcinoma after prior therapy
Oncology Phase II
Becotatug vedotin shows 20.9% objective response in recurrent head and neck squamous cell carcinoma after prior therapy For patients with advanced head and neck cancer, a new drug showed a 21% response rate in early testing
This multicenter, Phase IIa trial evaluated intravenous becotatug vedotin in 67 patients with recurrent or metastatic squamous cell carcinom…
A new drug shrank tumors in 21% of patients with advanced head and neck cancer who had run out of standard treatment options.
Apr 16, 2026

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