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Home › Medications › tadalafil

tadalafil

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of tadalafil

48 trials tracked of tadalafil: 28 in phase 3 or 4 and 5 with published results. The most-cited published study has 165 citations.

48Trials tracked
28Phase 3 & 4
0Recruiting
5With published results
Phase distribution
Phase 4 11 Phase 3 17 Phase 2 13 Phase 1 3 Other / NA 4
  1. Phase 3 The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertension Completed · 165 cited
  2. Phase 4 Riociguat rEplacing PDE-5i Therapy evaLuated Against Continued PDE-5i thErapy Completed · 160 cited
  3. Phase 3 Tadalafil in Preventing Erectile Dysfunction in Patients With Prostate Cancer Treated With Radiation Therapy Completed · 62 cited
  4. Phase 3 Tadalafil for Sarcoidosis Associated Pulmonary Hypertension Completed · 42 cited
  5. Phase 3 A Trial of Tadalafil and Glycemic Traits Completed · 38 cited
  6. Phase 4 A Study of Tadalafil (LY450190) in Participants With Lower Urinary Tract Symptoms (LUTS) Suggestive of Benign Prostatic Hyperplasia LUTS (BPH-LUTS). Completed
Show 42 more trials
  1. Phase 4 A 48-week Study of the Effect of Dual Therapy (Inhaled Treprostinil and Tadafafil) Versus Monotherapy (Tadalafil). Completed
  2. Phase 4 A Study of Tadalafil (LY450190) in Chinese Men With Erectile Dysfunction Completed
  3. Phase 4 Effect of Tadalafil on Insulin Secretion and Insulin Sensitivity in Obese Men. Completed
  4. Phase 4 A Study in Erectile Dysfunction Completed
  5. Phase 4 A Study of Tadalafil and Sildenafil in Men With Erectile Dysfunction in China Completed
  6. Phase 4 A Study of Tadalafil After Radical Prostatectomy Completed
  7. Phase 4 A Study in Patients With Erectile Dysfunction Completed
  8. Phase 4 Study of Add-on Ambrisentan Therapy to Background Phosphodiesterase Type-5 Inhibitor (PDE5i) Therapy in Pulmonary Arterial Hypertension (ATHENA-1) Completed
  9. Phase 4 A Study in Erectile Dysfunction Completed
  10. Phase 3 A Study of Tadalafil in Pediatric Participants With Pulmonary Arterial Hypertension (PAH) Completed
  11. Phase 3 Phase 3 Study of Tadalafil Once-Daily in Asian Men With Benign Prostatic Hyperplasia (BPH) Completed
  12. Phase 3 Effect of Tadalafil Once a Day in Men With Erectile Dysfunction Completed
  13. Phase 3 Study the Safety and Effectiveness of Tadalafil on High Blood Pressure in the Blood Vessel Going From the Heart to the Lungs Completed
  14. Phase 3 A Study of Tadalafil in Men With Benign Prostatic Hyperplasia Symptoms Who Are Being Treated With Alpha Blockers Completed
  15. Phase 3 A Study in the Treatment of Erectile Dysfunction and Benign Prostate Hyperplasia Completed
  16. Phase 3 Study to Treat Patients Who Have Signs and Symptoms of Benign Prostatic Hyperplasia (BPH) With Tadalafil Daily Completed
  17. Phase 3 A Study in Benign Prostatic Hyperplasia Completed
  18. Phase 3 A Study of First-Line Ambrisentan and Tadalafil Combination Therapy in Subjects With Pulmonary Arterial Hypertension (PAH) Completed
  19. Phase 3 Study of Tadalafil Once-a Day for 12 Weeks in Men With Signs and Symptoms of Benign Prostatic Hyperplasia Completed
  20. Phase 3 A Study of Tadalafil Use With Finasteride in Men With Enlarged Prostates and Urinary Symptoms Completed
  21. Phase 3 Multinational Study to Evaluate Tadalafil in Asian Men With Signs and Symptoms of Benign Prostatic Hyperplasia Completed
  22. Phase 3 Tadalafil Taken Daily Compared to Placebo on Improvement of Getting and Maintaining an Erection and Sexual Quality of Life Completed
  23. Phase 2 Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2) Completed
  24. Phase 2 Effects of Tadalafil Once a Day for 12 Weeks in Men With Signs and Symptoms of Benign Prostatic Hyperplasia Completed
  25. Phase 2 Tadalafil for Pulmonary Hypertension Due to Chronic Lung Disease Completed
  26. Phase 2 A Study of LY2623091 in Participants With High Blood Pressure Completed
  27. Phase 2 Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Diastolic Cardiomyopathy (Aim3) Completed
  28. Phase 2 Tadalafil and Pembrolizumab in Recurrent or Metastatic Head and Neck Cancer Completed
  29. Phase 2 A Study of LY900010 in Erectile Dysfunction Completed
  30. Phase 2 Tadalafil and Nesiritide as Therapy in Pre-clinical Heart Failure Completed
  31. Phase 2 PDE5 Inhibition for Obesity-Related Cardiometabolic Dysfunction Completed
  32. Phase 2 A Phase II Trial of Tadalafil in Patients With Squamous Cell Carcinoma of the Upper Aero Digestive Tract Completed
  33. Phase 2 Pilot Study Investigating Safety and Efficacy of Tadalafil as Treatment for Benign Prostatic Hyperplasia (BPH) in Asian Men Completed
  34. Phase 2 A Trial of Tadalafil in Patients With Squamous Cell Carcinoma of the Upper Aero Digestive Tract Completed
  35. Phase 2 Study of CRS-207, Pembrolizumab, Ipilimumab, and Tadalafil in Metastatic Pancreatic Cancer Completed
  36. Phase 1 A Bioavailability Study of LY2452473 and Tadalafil Completed
  37. Phase 1 A Study of Tadalafil in Benign Prostatic Hyperplasia Completed
  38. Phase 1 A Study of LY2623091 in Healthy Participants Completed
  39. N/A Tadalafil in Treating Patients Undergoing Surgery for Cancer of the Oral Cavity or Oropharynx Completed
  40. N/A Tadalafil for the Treatment of Raynaud's Completed
  41. N/A The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue Completed
  42. N/A Renin Angiotensin Aldosterone System (RAAS) and Fibrinolysis in Humans: ACEi and PE5i Completed

Showing the 48 most-cited and recently-updated of 48 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
PDE5 inhibitors increased cerebral blood flow in white matter hyperintensity regions in adults with cerebral small vessel disease
Neurology Meta-analysis
PDE5 inhibitors increased cerebral blood flow in white matter hyperintensity regions in adults with cerebral small vessel disease An Old Drug Class May Protect the Brain From Silent Damage
This systematic review and meta-analysis evaluated phosphodiesterase-5 inhibitors (sildenafil or tadalafil) versus placebo in 236 adults wit…
Drugs already approved for other conditions may help restore blood flow in a part of the brain that quietly fuels strokes and dementia.
Frontiers Apr 14, 2026
Tadalafil reduces some plasma neurodegeneration biomarkers in type 2 diabetes patients
Diabetes & Endocrinology RCT
Tadalafil reduces some plasma neurodegeneration biomarkers in type 2 diabetes patients Small study finds tadalafil may lower some Alzheimer's biomarkers in diabetes patients
A post-hoc analysis of a 6-week RCT in 15 individuals with type 2 diabetes found tadalafil reduced plasma amyloid-β 40, amyloid-β 42, and gl…
A small study suggests tadalafil lowers certain Alzheimer's-related blood markers in people with type 2 diabetes, though it did not change o…
Apr 8, 2026
Dutasteride-Tadalafil FDC Shows Superior Symptom Reduction in BPH Phase III Trial
Urology RCT
Dutasteride-Tadalafil FDC Shows Superior Symptom Reduction in BPH Phase III Trial Does taking two prostate drugs together work better than just one for symptom relief?
A phase III randomized trial in 619 BPH patients found a fixed-dose combination (FDC) of dutasteride 0.5 mg/tadalafil 5 mg significantly imp…
Men taking two prostate drugs together saw symptom relief twice as fast as single-drug therapy, though they faced more side effects.
Apr 6, 2026