PDE5 inhibitors increased cerebral blood flow in white matter hyperintensity regions in adults with cerebral small vessel disease.
An Old Drug Class May Protect the Brain From Silent Damage
This systematic review and meta-analysis evaluated phosphodiesterase-5 inhibitors (sildenafil or tadalafil) versus placebo in 236 adults wit…
Drugs already approved for other conditions may help restore blood flow in a part of the brain that quietly fuels strokes and dementia.
Tadalafil reduces some plasma neurodegeneration biomarkers in type 2 diabetes patients
Small study finds tadalafil may lower some Alzheimer's biomarkers in diabetes patients
A post-hoc analysis of a 6-week RCT in 15 individuals with type 2 diabetes found tadalafil reduced plasma amyloid-β 40, amyloid-β 42, and gl…
A small study suggests tadalafil lowers certain Alzheimer's-related blood markers in people with type 2 diabetes, though it did not change o…
Dutasteride-Tadalafil FDC Shows Superior Symptom Reduction in BPH Phase III Trial
Does taking two prostate drugs together work better than just one for symptom relief?
A phase III randomized trial in 619 BPH patients found a fixed-dose combination (FDC) of dutasteride 0.5 mg/tadalafil 5 mg significantly imp…
Men taking two prostate drugs together saw symptom relief twice as fast as single-drug therapy, though they faced more side effects.