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Home › Conditions › Benign Prostatic Hyperplasia

Benign Prostatic Hyperplasia

Part of Prostatic Diseases

14 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Benign Prostatic Hyperplasia

55 trials tracked for Benign Prostatic Hyperplasia: 22 in phase 3 or 4 and 1 with published results. The most-cited published study has 15 citations.

55Trials tracked
22Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 7 Phase 3 15 Phase 2 13 Phase 1 1 Other / NA 19
  1. Phase 3 Clinical Trial of Safety and Efficacy of Afalaza in Patients With Symptoms of Benign Prostatic Hyperplasia and Risk of Progression Completed · 15 cited
  2. Phase 4 A Study of Tadalafil (LY450190) in Participants With Lower Urinary Tract Symptoms (LUTS) Suggestive of Benign Prostatic Hyperplasia LUTS (BPH-LUTS). Completed
  3. Phase 4 A Study to Evaluate the Efficacy, Safety, and Tolerability of Mirabegron in Men With OAB Symptoms While Taking Tamsulosin Hydrochloride for Lower Urinary Tract Symptoms (LUTS) Due to Benign Prostatic Hyperplasia (BPH) Completed
  4. Phase 4 Self-Administered Nitrous Oxide (SANO) During Transrectal Prostate Biopsy to Reduce Patient Anxiety and Pain Completed
  5. Phase 4 Deprescribing Tamsulosin in Older Men Completed
  6. Phase 4 TRADE-Testosterone Replacement and Dutasteride Effectiveness Completed
Show 44 more trials
  1. Phase 4 A Long-Term Study Examining the Treatment of Benign Prostatic Hyperplasia With Photoselective Vaporization Completed
  2. Phase 4 Dutasteride and Flex Dose of Tamsulosin on as Needed Basis, to Treat Benign Prostatic Hyperplasia Completed
  3. Phase 3 A Comparison of Traditional and MOSES Laser Enucleation of the Prostate (MOLEP): A Prospective, Randomized, Double-blinded Control Trial A Comparison of Traditional and MOSES Laser Enucleation of the Prostate (MOLEP): A Prospective, Randomized, Double-blinded Control Trial Completed
  4. Phase 3 Phase 3 Study of Tadalafil Once-Daily in Asian Men With Benign Prostatic Hyperplasia (BPH) Completed
  5. Phase 3 Dutasteride 0.5mg For The Treatment Of Chinese Patients With Benign Prostatic Hyperplasia (BPH) Completed
  6. Phase 3 A Study of Tadalafil in Men With Benign Prostatic Hyperplasia Symptoms Who Are Being Treated With Alpha Blockers Completed
  7. Phase 3 A Study in the Treatment of Erectile Dysfunction and Benign Prostate Hyperplasia Completed
  8. Phase 3 Study to Treat Patients Who Have Signs and Symptoms of Benign Prostatic Hyperplasia (BPH) With Tadalafil Daily Completed
  9. Phase 3 A New Drug for Benign Prostatic Hyperplasia (BPH) Compared With Placebo Completed
  10. Phase 3 A Study in Benign Prostatic Hyperplasia Completed
  11. Phase 3 The Evaluation of the Safety of a New Drug for Benign Prostatic Hyperplasia Used for 9 Months Completed
  12. Phase 3 Study of Solifenacin Succinate and Tamsulosin Hydrochloride OCAS in Males With Lower Urinary Tract Symptoms Completed
  13. Phase 3 Study of Tadalafil Once-a Day for 12 Weeks in Men With Signs and Symptoms of Benign Prostatic Hyperplasia Completed
  14. Phase 3 A Study of Tadalafil Use With Finasteride in Men With Enlarged Prostates and Urinary Symptoms Completed
  15. Phase 3 Multinational Study to Evaluate Tadalafil in Asian Men With Signs and Symptoms of Benign Prostatic Hyperplasia Completed
  16. Phase 3 Long Term Study of Solifenacin Succinate and Tamsulosin Hydrochloride Oral Controlled Absorption System (OCAS) in Males With Lower Urinary Tract Symptoms Completed
  17. Phase 2 Botulinum Toxin Injection for the Management of BPH Completed
  18. Phase 2 Effects of Tadalafil Once a Day for 12 Weeks in Men With Signs and Symptoms of Benign Prostatic Hyperplasia Completed
  19. Phase 2 Effectiveness of onaBoNT-A vs Oral Tamsulosin in Men With BPH and LUTS Completed
  20. Phase 2 Prostate Embolization for Benign Prostatic Hyperplasia Completed
  21. Phase 2 Study of Tadalafil Once-a-Day for 12 Weeks in Japanese Men With Benign Prostatic Hyperplasia Followed by an Open-Label Extension Completed
  22. Phase 2 Cyclooxygenase-2 (COX-2) Inhibitor Reduces Serum Prostatic Specific Antigen (PSA) Levels Completed
  23. Phase 2 Pilot Study Investigating Safety and Efficacy of Tadalafil as Treatment for Benign Prostatic Hyperplasia (BPH) in Asian Men Completed
  24. Phase 2 Optilume™ BPH Prostatic Drug Coated Balloon Dilation Catheter Completed
  25. Phase 2 Efficacy and Safety of S-Equol on Men With Benign Prostatic Hyperplasia Completed
  26. Phase 2 A Study Evaluating the Effect of Botulinum Toxin Type A on Semen Quality in Patients With Benign Prostatic Hyperplasia Completed
  27. Phase 2 Safety and Efficacy Study of Botulinum Toxin Type A to Treat Lower Urinary Symptoms Due to Benign Prostatic Hyperplasia Completed
  28. Phase 2 Transperineal Intraprostatic Injection of PRX302 Under Ultrasound Guidance for Management of Prostatic Hyperplasia Completed
  29. Phase 2 Safety and Efficacy of Botulinum Toxin Type A to Treat Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia Completed
  30. Phase 1 A Study of Tadalafil in Benign Prostatic Hyperplasia Completed
  31. N/A An Observational Study of Radial Access Embolization Procedures Using HydroPearl Microspheres Completed
  32. N/A Anti-Androgen Treatment for COVID-19 Completed
  33. N/A BPH-6: Comparison of the UroLift System to TURP for Benign Prostatic Hyperplasia Completed
  34. N/A The Safety and Effectiveness of UroLift: LIFT Pivotal Study Completed
  35. N/A Prostate Artery Embolization for the Treatment of Symptomatic Benign Prostatic Hyperplasia Completed
  36. N/A Safety and Efficacy Study for the Treatment of BPH (Enlarged Prostate) Completed
  37. N/A UroLift System TOlerability and ReCovery When Administering Local Anesthesia Completed
  38. N/A Rezum I Pilot Study for Benign Prostatic Hyperplasia Completed
  39. N/A Rezum FIM Optimization Study Completed
  40. N/A Embosphere® PROstate Post Market Study Completed
  41. N/A Research on Benefit of Umooze as Add- on Therapy in Benign Prostatic Hyperplasia Completed
  42. N/A GreenLight XPS Laser System Retrospective Chart Review Completed
  43. N/A Flexiva Pulse Registry Completed
  44. N/A Prostate Artery Embolization (PAE) for Lower Urinary Tract Symptoms (LUTS) Due to Benign Prostatic Hyperplasia (BPH) Completed

Showing the 50 most-cited and recently-updated of 55 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
5-alpha-reductase inhibitors are associated with increased sexual adverse events in androgenetic alopecia patients
Oncology Meta-analysis
5-alpha-reductase inhibitors are associated with increased sexual adverse events in androgenetic alopecia patients Hair loss medications may cause some side effects for men
This systematic review of 41 studies evaluates the impact of finasteride and dutasteride on sexual dysfunction in patients with hair loss. T…
Men using finasteride or dutasteride for hair loss may experience sexual side effects, though most cases are mild and reversible when the dr…
Frontiers Jun 29, 2026
Infliximab may offer clinical improvement and wound reduction in non-Crohn's disease related fistulas
Gastroenterology Sys. Review
Infliximab may offer clinical improvement and wound reduction in non-Crohn's disease related fistulas Infliximab shows promise for complex fistulas in prostate cancer patients
This case report and mini-review describes a 76-year-old man with prostate cancer and non-Crohn's disease related fistulas treated with infl…
A new case report suggests that the drug infliximab may help treat difficult fistulas in men with a history of prostate cancer.
Frontiers Jun 16, 2026
Curcumin supplementation improves IPSS scores by 4.11 points in men with benign prostatic hyperplasia
Urology Meta-analysis
Curcumin supplementation improves IPSS scores by 4.11 points in men with benign prostatic hyperplasia Curcumin Shows Potential for Managing Benign Prostatic Hyperplasia Symptoms
This meta-analysis of 697 patients evaluated curcumin as an adjunct for benign prostatic hyperplasia (BPH). The analysis found a significant…
New research suggests that curcumin may help improve urinary symptoms and prostate health in men with enlarged prostates.
Jun 10, 2026
Meta-analysis shows shorter operative time and hospital stay with ThuLEP versus RASP for large-volume BPH
Rheumatology Meta-analysis
Meta-analysis shows shorter operative time and hospital stay with ThuLEP versus RASP for large-volume BPH Laser surgery beats robot surgery for big prostates in new review
This systematic review and meta-analysis evaluated Robot-assisted simple prostatectomy (RASP) versus laser enucleation of the prostate (LEP)…
New research shows laser surgery beats robot surgery for big prostates by cutting time and catheter use
Frontiers May 5, 2026
Machine Learning Model Improves Prediction of Detrusor Underactivity in BPH Patients
Rheumatology Cohort
Machine Learning Model Improves Prediction of Detrusor Underactivity in BPH Patients Smart computer program spots bladder weakness before prostate surgery starts
This retrospective cohort study of 538 urodynamically evaluated BPH patients found that an interpretable machine learning model (XGBoost) ou…
A new computer system predicts bladder weakness in men with prostate problems before they go under the knife for surgery.
Frontiers May 1, 2026
ThuFLEP non-inferior to HoLEP for benign prostatic obstruction symptom relief at 24 months
Urology RCT
ThuFLEP non-inferior to HoLEP for benign prostatic obstruction symptom relief at 24 months Two laser prostate surgeries offer the same long-term relief for men
This randomized non-inferiority trial compared thulium fiber laser enucleation (ThuFLEP) to holmium laser enucleation (HoLEP) in 150 patient…
Men with enlarged prostates can choose between two laser surgeries that provide equal relief and safety over two years
Apr 29, 2026
Mind map-guided nursing reduces pain and improves recovery in BPH patients undergoing TURP
Urology RCT
Mind map-guided nursing reduces pain and improves recovery in BPH patients undergoing TURP Mind Maps Help Patients Recover Faster After Prostate Surgery
This randomized controlled trial enrolled 80 patients with benign prostatic hyperplasia undergoing TURP.
Imagine waking up after surgery feeling less pain and ready to move around sooner.
Apr 23, 2026
Nomogram predicts bladder stone risk in BPH patients after prostate resection
Rheumatology Cohort
Nomogram predicts bladder stone risk in BPH patients after prostate resection New model predicts bladder stone risk in BPH patients after prostate surgery
This retrospective cohort study developed a nomogram to predict bladder stone risk in 446 BPH patients after transurethral resection.
A new tool helps doctors estimate bladder stone risk for men with enlarged prostates after surgery, based on a study of 446 patients.
Frontiers Apr 23, 2026
Machine Learning Model Predicts Histological Prostatitis in Patients With Benign Prostatic Hyperplasia
Urology Cohort
Machine Learning Model Predicts Histological Prostatitis in Patients With Benign Prostatic Hyperplasia Machine learning model predicts prostatitis in men with enlarged prostate
This single-center retrospective machine-learning prediction model study evaluated 723 patients admitted to a urology department for benign …
A new model using patient data accurately identified which men with enlarged prostates also had hidden prostate inflammation.
Frontiers Apr 22, 2026
In an RCT, dutasteride significantly reduced total International Prostate Symptom Score in men with lower urinary tract symptoms over 24 months
Urology RCT
In an RCT, dutasteride significantly reduced total International Prostate Symptom Score in men with lower urinary tract symptoms over 24 months Dutasteride Helps Bladder Flow, But Nighttime Relief Takes Years
This randomized controlled trial enrolled 8122 men with lower urinary tract symptoms and compared dutasteride to placebo over a 24.0-month f…
This common prostate medication works well for flow, but full bladder comfort comes slowly and may not be noticeable.
Apr 21, 2026
Dutasteride-Tadalafil FDC Shows Superior Symptom Reduction in BPH Phase III Trial
Urology RCT
Dutasteride-Tadalafil FDC Shows Superior Symptom Reduction in BPH Phase III Trial Does taking two prostate drugs together work better than just one for symptom relief?
A phase III randomized trial in 619 BPH patients found a fixed-dose combination (FDC) of dutasteride 0.5 mg/tadalafil 5 mg significantly imp…
Men taking two prostate drugs together saw symptom relief twice as fast as single-drug therapy, though they faced more side effects.
Apr 6, 2026
Prior HoLEP association with longer operative time and catheter duration in subsequent RARP
Urology Meta-analysis
Prior HoLEP association with longer operative time and catheter duration in subsequent RARP Does prior prostate surgery make your next operation harder or riskier?
This systematic review and meta-analysis of three retrospective studies compared men undergoing robot-assisted radical prostatectomy (RARP) …
Prior prostate surgery makes the next operation take longer and requires more rebuilding, but cancer removal and recovery remain just as eff…
Apr 6, 2026

Questions about Benign Prostatic Hyperplasia

What is the risk of developing bladder stones after prostate resection for BPH?

After prostate resection for BPH, the risk of developing bladder stones is low but increases with certain factors like larger prostate volume, higher symptom scores, and elevated uric acid.

Full answer →
Does ThuLEP surgery result in a shorter hospital stay compared to RASP for large BPH?

Yes, ThuLEP generally results in a shorter hospital stay than RASP for large BPH, though some studies show no difference.

Full answer →

All Benign Prostatic Hyperplasia Articles