Intrawound vancomycin powder reduces postoperative infection risk (OR 0.59) in high-risk fracture fixation cases
Vancomycin Powder May Reduce Infections After High Risk Fractures
This meta-analysis of 3185 patients found that intrawound vancomycin powder significantly reduced postoperative infection rates (OR 0.59; 95…
A review of data suggests that using vancomycin powder in wounds may lower infection rates for patients with serious bone fractures.
Model-informed precision dosing improves vancomycin target attainment in critically ill children compared to standard therapeutic drug monitoring
New dosing model helps severely ill children hit drug targets faster
In critically ill children, model-informed precision dosing significantly improved vancomycin target attainment versus standard monitoring. …
A new dosing method helped more critically ill children reach the right drug levels in their blood within two days of starting treatment for…
Meta-analysis links vincristine and other drugs to higher cisplatin hearing loss risk in pediatric cancer
Hidden Danger in Kids' Cancer Treatment Raises Hearing Loss Risk
This meta-analysis of observational studies synthesized evidence on concomitant medications and cisplatin-induced hearing loss in pediatric …
• Four common drugs nearly quadruple hearing damage during chemo • Helps oncologists protect children from silent treatment side effects • D…
Intrawound tobramycin plus vancomycin did not reduce deep infection risk compared with vancomycin alone in high-risk tibial fractures
Adding Antibiotics to Bone Surgery Didn't Lower Infection Risk
This randomized clinical trial evaluated adults with operatively treated periarticular tibial fractures at elevated infection risk. Among 16…
A major trial found that adding a second antibiotic powder directly into bone fractures during surgery failed to lower infection rates compa…
Positive in vitro interactions with β-lactam linked to lower 14-day mortality in MRSA bacteraemia
Positive lab interactions linked to lower early death in MRSA infection treatment
This post hoc analysis of a multicentre randomized trial included 150 adults with MRSA bacteraemia.
When lab tests showed bacteria died better with combined drugs, patients had lower early death rates. This finding suggests smarter drug pai…
CRS3123 shows efficacy in phase 2 trial for Clostridioides difficile infection
Early trial shows CRS3123 matches vancomycin for treating C. diff infection
This phase 2 randomized trial compared CRS3123 with vancomycin in 43 adults with CDI.
A small Phase 2 trial found CRS3123 worked as well as vancomycin for curing C. diff infection in adults with their first episode or recurren…
Meta-analysis shows pharmacist interventions improve vancomycin TDM outcomes and reduce kidney injury risk
Pharmacist oversight improves vancomycin safety and success rates in patients
This meta-analysis evaluated pharmacist interventions versus non-pharmacist interventions in patients treated with vancomycin under therapeu…
A large review shows pharmacist involvement lowers kidney injury risk and improves blood levels for patients taking vancomycin.
Electronic health record study links prior antimicrobial resistance to bacteraemia in cancer patients
Prior Antibiotic Resistance Linked to Higher Bacteraemia Risk in Cancer Patients
This electronic health record study analyzed 2752 adults with cancer diagnostic codes in Oxfordshire, UK, between 2015 and 2025.
Past antibiotic resistance in cancer patients strongly predicts future bloodstream infections, with specific cancer types increasing odds of…
FMT shifts bile acids faster than vancomycin in recurrent C. difficile infection subgroup
Study looks at bile acids and recurrent C. diff treatments
This randomized controlled trial subgroup analyzed patients with recurrent Clostridioides difficile infection.
Treating recurrent C. diff infection with FMT shifts bile acids faster than vancomycin, restoring a healthy pattern linked to the presence o…
Vancomycin AUC24 Monitoring Correlates With Trough Levels in Pediatric MRSA Inpatients: A Prospective Multicenter Study
Better Vancomycin Dosing Could Protect Children’s Kidneys
This prospective multicenter cohort study included 70 pediatric inpatients with methicillin-resistant Staphylococcus aureus (MRSA).
A new way to measure antibiotic levels in children may prevent kidney damage while fighting infection.
Narrative review suggests combination regimens over vancomycin monotherapy for Elizabethkingia meningoseptica infections
Is vancomycin alone safe for a rare infection that might actually need a stronger team approach?
This narrative review addresses Elizabethkingia meningoseptica infections, noting that frequent misidentification between E.
Doctors should combine vancomycin with other antibiotics instead of using it alone to treat rare Elizabethkingia infections, because relying…
Retrospective cohort study examines MRSA prevalence and resistance patterns in nosocomial bloodstream infections among 96 patients in central China
Are hospital infections getting harder to treat, or is the data stable?
This retrospective cohort study analyzed 96 Staphylococcus aureus isolates from patients with nosocomial bloodstream infections at a tertiar…
Hospital bloodstream infections from tough MRSA bacteria stayed stable in frequency, but one patient's germ was resistant to the last-resort…