PPI deprescription associated with 3.66 odds of CDI in hospitalized older adults
Stopping certain acid medications might increase risk of stomach infection
This quasi-interventional substudy of a cluster randomized trial involved 4990 hospitalized older adults taking five or more medications. Th…
A study of nearly 5,000 hospitalized seniors found that stopping specific acid-reducing drugs could actually lead to more frequent infection…
Fidaxomicin and vancomycin pulse and taper regimens show potential for reducing Clostridioides difficile recurrence
Fidaxomicin and Vancomycin Pulse Regimens May Reduce Infection Recurrence
Researchers evaluated various treatment regimens, including fidaxomicin and vancomycin pulse and taper strategies, for managing Clostridioid…
New analysis suggests that specific dosing schedules for fidaxomicin and vancomycin may be more effective at preventing recurring C. diffici…
CRS3123 shows efficacy in phase 2 trial for Clostridioides difficile infection
Early trial shows CRS3123 matches vancomycin for treating C. diff infection
This phase 2 randomized trial compared CRS3123 with vancomycin in 43 adults with CDI.
A small Phase 2 trial found CRS3123 worked as well as vancomycin for curing C. diff infection in adults with their first episode or recurren…
Review of Fluoroquinolone Restriction Implementation Modifications for C. difficile Prevention
Hospital plans to stop risky drugs often changed during real-world rollout
This review analyzes modifications to fluoroquinolone restriction implementation strategies from the FIRST trial across four diverse hospita…
Plans to limit risky fluoroquinolones often changed during rollout. Rural hospitals needed more tweaks than academic centers.
FMT shifts bile acids faster than vancomycin in recurrent C. difficile infection subgroup
Study looks at bile acids and recurrent C. diff treatments
This randomized controlled trial subgroup analyzed patients with recurrent Clostridioides difficile infection.
Treating recurrent C. diff infection with FMT shifts bile acids faster than vancomycin, restoring a healthy pattern linked to the presence o…
Fecal microbiota transplantation shows efficacy for recurrent C. difficile infection, IBD, and autism spectrum disorder in children
A Gut Reset Treatment Is Helping Sick Kids Bounce Back
This systematic review and meta-analysis of 47 studies evaluated fecal microbiota transplantation (FMT) in children with recurrent C.
A gut bacteria transplant helps children with stubborn infections, bowel disease, and autism symptoms, though kids with IBD face more side e…
ACIP updates adult vaccination recommendations, allowing Tdap or Td in more scenarios
New vaccine rules give adults more options for tetanus and whooping cough protection
The Advisory Committee on Immunization Practices has updated recommendations for adult vaccination in the United States.
Adults in the U.S. now have more options for their tetanus shots, as health advisors say both Tdap and Td vaccines are acceptable for routin…
Case report describes illnesses in women after presumed counterfeit botulinum toxin injections in nonmedical settings
Women became ill after receiving counterfeit botulinum toxin injections in nonmedical settings
A case report describes illnesses in women following administration of presumed counterfeit botulinum toxin injections in nonmedical setting…
Women fell ill after receiving counterfeit botulinum toxin injections outside medical settings, highlighting the dangers of unlicensed provi…
Influenza and Tdap vaccination coverage among pregnant women in the United States
Report examines flu and whooping cough vaccination rates in pregnant women
An observational report describes influenza and Tdap vaccination coverage among pregnant women in the United States.
A new report examines flu and whooping cough vaccination rates for pregnant women during the 2019-20 season, highlighting the need for more …
New 6-in-1 infant vaccine licensed but availability delayed until at least 2021
New six-in-one vaccine for infants receives regulatory approval
A new combination vaccine for infants targeting diphtheria, tetanus, pertussis, polio, Hib, and hepatitis B has received licensure.
A new six-in-one vaccine for infants has received regulatory approval, but it won't be available for use until 2021 or later.
Questions about Clostridioides difficile infection
Does limiting fluoroquinolone antibiotics help prevent Clostridioides difficile infection in hospitals?
Limiting fluoroquinolone antibiotics is a proven strategy to prevent Clostridioides difficile infection because these drugs carry a high risk of causing the illness compared to other antibiotics.
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