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Home › Medications › varenicline

varenicline

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of varenicline

129 trials tracked of varenicline: 60 in phase 3 or 4 and 27 with published results. The most-cited published study has 183 citations.

129Trials tracked
60Phase 3 & 4
0Recruiting
27With published results
Phase distribution
Phase 4 37 Phase 3 23 Phase 2 37 Phase 1 2 Other / NA 30
  1. Phase 4 A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers Completed · 183 cited
  2. Phase 4 Study To Evaluate Cardiac Assessments Following Different Treatments Of Smoking Cessation Medications In Subjects With And Without Psychiatric Disorders. Completed · 149 cited
  3. Phase 4 Varenicline Adjunctive Treatment in Schizophrenia Completed · 141 cited
  4. Phase 3 Evaluation of Varenicline (Champix) in Smoking Cessation for Patients Post-Acute Coronary Syndrome (EVITA) Trial Completed · 136 cited
  5. Phase 3 Pharmacogenetics, Emotional Reactivity and Smoking Completed · 134 cited
  6. Phase 3 Varenicline for Adolescent Smoking Cessation Completed · 112 cited
Show 44 more trials
  1. Phase 3 Combining Varenicline and Bupropion for Smoking Cessation Completed · 112 cited
  2. Phase 4 Varenicline Effects In Schizophrenic Smokers Completed · 106 cited
  3. Phase 4 Relapse Prevention With Varenicline Completed · 72 cited
  4. Phase 4 Smoking Cessation Treatment for Methadone Maintenance Patients Completed · 72 cited
  5. Phase 4 Varenicline for Cognitive Deficits and Cigarette Smoking in Schizophrenia - Efficacy and Predictors Completed · 72 cited
  6. Phase 4 Varenicline and Combined NRT for Smoking Cessation Completed · 72 cited
  7. Phase 3 Maintaining Nonsmoking Completed · 72 cited
  8. Phase 4 Understanding Disparities in Quitting in African American and White Smokers Completed · 63 cited
  9. Phase 4 UW Quitting Using Intensive Treatment Study (QUITS) Completed · 57 cited
  10. Phase 3 Varenicline for Nicotine Dependence Among Those With HIV/AIDS Completed · 46 cited
  11. Phase 4 Genetically Informed Smoking Cessation Trial Completed · 36 cited
  12. Phase 3 EVarQuit: Extended Pre-quit Varenicline to Assist in Quitting Smoking Completed · 30 cited
  13. Phase 4 Varenicline for Light Smokers Completed · 27 cited
  14. Phase 4 Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders Completed · 25 cited
  15. Phase 4 Extended Treatment for Smoking Cessation Completed · 23 cited
  16. Phase 4 Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers Completed · 12 cited
  17. Phase 3 Individualizing Pharmacotherapy for African American Smokers Completed · 10 cited
  18. Phase 4 Cannabis and Tobacco Co-use Study Completed · 3 cited
  19. Phase 4 UW-CTRI Triple Medication Smoking Cessation Study Completed · 2 cited
  20. Phase 3 PRecision Interventions for SMoking in the SCCS Completed · 2 cited
  21. Phase 3 Optimizing Smoking Cessation for People With HIV/AIDS Who Smoke Completed
  22. Phase 4 Effectiveness of Varenicline: Testing Individual Differences Completed
  23. Phase 4 A Smoking Cessation Intervention for Yale Dining Employees Completed
  24. Phase 4 Balanced Placebo Design With Varenicline: Pharmacological and Expectancy Effects on Medication Adherence Completed
  25. Phase 4 Varenicline Light Smoking Pilot Completed
  26. Phase 4 Mobile Evidence-Based Smoking Cessation for Veterans Living With HIV (MESH) Completed
  27. Phase 4 Novel Pharmacotherapy Approaches in Smokers With Serious Mental Illness Completed
  28. Phase 4 Health Systems Reach Interventions Project Completed
  29. Phase 4 Tobacco Treatment Comparison for Cancer Care Completed
  30. Phase 4 A Study of Varenicline for Prevention of Relapse to Smoking in Patients With Schizophrenia or Bipolar Disorder Completed
  31. Phase 4 A Study To Evaluate The Efficacy And Safety Of Varenicline Compared To Placebo For Smoking Cessation Through Reduction Completed
  32. Phase 4 Safety And Efficacy Of 12 Weeks Of Varenicline For Smoking Cessation In Smokers With Depression Completed
  33. Phase 4 Assessing Neuropsychiatric Symptoms Including Depression, Anxiety, Irritability, and Suicidal Thoughts or Behavior in Subjects Quitting Smoking on Varenicline Tartrate or Placebo Completed
  34. Phase 4 Long-term Varenicline Treatment for Smoking Cessation Completed
  35. Phase 4 Varenicline Treatment for Smoking Cessation in Patients With Bipolar Disorder Completed
  36. Phase 4 A Multi-National Study To Assess How Effective And Safe The Smoking Cessation Medicine Varenicline Is In Smokers Who Have Already Tried Varenicline In The Past As A Prescription Medicine From Their Usual Healthcare Provider Completed
  37. Phase 4 Study Evaluating The Efficacy Of Varenicline In Cessation Of Oral Smokeless Tobacco Use Completed
  38. Phase 4 A Pilot Study Of Smoking Cessation Treatment Including Varenicline In Patients Scheduled For Planned Surgery Completed
  39. Phase 4 Distribution of Bupropion and Varenicline to Increase Smoking Cessation Attempts Completed
  40. Phase 4 Measuring Smoking Behaviors While Using Varenicline Completed
  41. Phase 4 Randomized Study Comparing the Efficacy and Safety of Varenicline Tartrate to Placebo in Smoking Cessation When Subjects Are Allowed to Set Their Own Quit Date Completed
  42. Phase 3 Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation Completed
  43. Phase 3 Extended Varenicline Treatment for Smoking Among Cancer Patients Completed
  44. Phase 3 Smoking Cessation & Opioid Dependence Treatment Integration Completed

Showing the 50 most-cited and recently-updated of 129 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers
Infectious Disease RCT
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers New data on nicotine treatment for HIV patients who use opioids
This secondary analysis of a randomized trial in 97 HIV-positive smokers with risky alcohol use and baseline opioid use found no significant…
A new look at nicotine treatment for HIV patients who use opioids found no difference in opioid use between two drug groups.
May 1, 2026
Adding Bupropion or Varenicline to NRT After ACS Linked to Lower Mortality
Cardiology Cohort
Adding Bupropion or Varenicline to NRT After ACS Linked to Lower Mortality Adding Prescription Meds to Nicotine Patches Lowers Heart Death Risk
This retrospective cohort study of 8,574 propensity-matched pairs found that adding bupropion or varenicline to NRT after ACS was associated…
Heart attack survivors who quit smoking with extra prescription help live longer.
medRxiv Apr 24, 2026