N/A N=68 Clinical Stabilization of Hypercapnia: NIPPV v HVNI
Hypercapnic Respiratory Failure · Chronic Obstructive Pulmonary Disease · Dyspnea
Primary: Rated Perceived Dyspnea [RPD] — 5.4; 5.6; 3.97; 4.54 units on a scale (0-10)
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=54 Ketamine Infusion and Hypoventilation
Hypoventilation
Primary: Intraoperative Hypoventilation — 1.2; 65 % time
N/A N=20 High Intensity Non-Invasive Positive Pressure Ventilation (HINPPV)
Chronic Obstructive Pulmonary Disease (COPD)
Primary: Daytime Partial Pressure of Carbon Dioxide in Arterial Blood (PaCO2) — 53; 50 mmHg — p=0.01
N/A N=70 The Effect of Ventilation on Cerebral Oxygenation in the Sitting Position
Cerebral Ischemia
Primary: Incidence of Cerebral Desaturation Events — 19; 3 number of events
N/A N=167 Using Capnography to Reduce Hypoxia During Pediatric Sedation
Hypoventilation · Hypoxia
Primary: Frequency of Staff Interventions for Hypoventilation. — 0.39; 0.396 Events per patient minute of sedation
N/A N=20 Effect of Alveolar Minute Ventilation on Respiratory Gas Heat Content
Ventilation Perfusion Mismatch
Primary: Airway Enthalpy — 32; 23 Joules/Minute
N/A N=29 Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease
Amyotrophic Lateral Sclerosis (ALS) · Neuromuscular Diseases
Primary: Percent Change in Maximal Inspiratory Pressure (MIP) — 0.3; -3.1; -4.8; -5.0 percentage change in MIP from baseline
Phase 2 N=22 Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI
Epilepsy · SUDEP
Primary: Study Recruitment Rate — 3.8 participants/3 months
N/A N=22 Non-invasive Ventilation System in Moderate-to-Severe Chronic Obstructive Pulmonary Disease (COPD)
Pulmonary Disease, Chronic Obstructive · Airflow Obstruction, Chronic · Chronic Obstructive Airway Disease
Primary: Device Tidal Volume — 180 mL
N/A N=25 Servo-Ventilation In-lab PSG Evaluation
Sleep Apnea Syndromes
Primary: Average Apnea Hypopnea Index Among Different Polysomnography Devices. — 18.4; 25.4; 24.1; 19.2 events per hour
N/A N=26 Volume Guarantee Ventilation in Preterm Infants With Frequent Episodes of Hypoxemia
Episodic Hypoxemia in Mechanically Ventilated Preterm Infants
Primary: Percentage of Time Spent With Arterial Oxygen Saturation < 75% — 5; 4.4 % of time — p=0.44
Phase 4 N=40 Effect of Neuromuscular Blockade and Reversal on Breathing
Respiratory Insufficiency
Primary: Breathing Increase Due to a Reduction in Inspired Oxygen Saturation (Hypoxic Ventilatory Response) — 0.66; 0.43; 0.54; 0.34 L/min/% desaturation
N/A N=39 A Comparison of Different Ventilation Strategies in Infants Using the PLMA™
Ventilation
Primary: Mean Values of End-tidal Carbon Dioxide and Tidal Volume Compared Between the Spontaneous Ventilation and Pressure Support Ventilation Groups. — 4.5; 7; 51.8; 49 cc/kg
N/A N=1,705 ED Lung Protective Ventilation to Reduce Complications
Mechanical Ventilation · Ventilator-associated Conditions · ARDS
Primary: Number of Patients That Experience Pulmonary Complications After Admission From the Emergency Department — 171; 38 participants
N/A N=22 Improved Patient Recovery After Anesthesia With Hypercapnia Hyperpnoea
Hypercapnia
Primary: Recovery From Anesthesia — 53.0; 62.9 minutes — p=>0.05
Phase 1 N=14 Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study
Infant Respiratory Distress Syndrome · Respiratory Insufficiency · Apnea of Prematurity
Primary: pCO2 Measurements Post-intervention, as Compared to Pre-intervention Values — 50; 45 mm Hg — p=0.011
N/A N=20 EPO2-PV: Evaluation of Pre-Oxygenation Conditions in Morbidly Obese Volunteer: Effect of Position and Ventilation Mode
Morbid Obesity · Bariatric Surgery Candidate
Primary: Functional Residual Capacity — 2573; 2145; 2456; 2219 ml
N/A N=92 Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep
Sleep Apnea · Age
Primary: Apneic Threshold (AT) and Carbon-dioxide (CO2) Reserve — 39.8; 36.7; -4.1; -2.6 mm Hg — p=<0.05
N/A N=219 Mechanical Ventilation in the Emergency Department: A Prospective Cross-Sectional Study
Respiratory Failure · Mechanical Ventilation · Acute Lung Injury
Primary: To Further Characterize ED Mechanical Ventilation — 500 mL
N/A N=524 Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome
Primary: Ventilator-free Days (VFDs) — 18.4; 16.1 days
N/A N=15 Effects of the Breathe Technologies Ventilation System in Subjects With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease
Primary: Exercise Duration for Constant Work Rate Exercise Tests Under 4 Test Conditions — 6.3; 17.5; 11.4; 5.6 minutes — p=<0.05
N/A N=7 Assessing Variability of the Ventilatory Response to Duffin's Rebreathing Procedure
Ventilation · Reproducibility · Physiology
Primary: Baseline Minute Ventilation — 11.6; 12.0 L/min
N/A N=23 Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Newly Diagnosed Patients
Nocturnal Hypoventilation · Neuromuscular Disease · Chest Wall Disorder
Primary: Overnight Mean Oxygen Saturation — 96; 96 % SaO2 — p=0.13
N/A N=21 Adjustment of Mask Pressure, for Bilevel Positive Airways Pressure Therapy, by Automated Algorithm
Respiratory Insufficiency · Sleep Disordered Breathing
Primary: Index of Apneoas Plus Hypopnoeas Per Hour of Sleep (AHI) — 1.3; 1.7 Events per hour of sleep
N/A N=50 The Effect of Prolonged Inspiratory Time on Pulmonary Mechanics in Obese Patients
Hypoxia
Primary: PaO2(Partial Pressure of Oxygen in Arterial Blood) — 178.71; 198.04; 185.25; 202.54 mmHg
N/A N=83 Non-Invasive Ventilation Via a Helmet Device for Patients Respiratory Failure
Acute Respiratory Distress Syndrome · Shock · Ventilatory Failure
Primary: Need for Endotracheal Intubation — 24; 8 Participants
N/A N=2,860 Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project
Orthopedic Surgery · Ventilation
Primary: Time-weighted Average SaO2/FiO2 Ratio in the Postanesthesia Care Unit (PACU) — 355; 350; 353; 352 ratio — p=0.042
N/A N=6 Rebreathing of Carbon Dioxide With a Device Used for Giving Inhalational Anaesthesia
Anesthetic Ventilatory Requirements
Primary: Airway Dead Space With Devices for Heat and Moisture Exchange of Respiratory Gas. — 136 mL
N/A N=81 Helmet Continuous Positive Airway Pressure (CPAP) Versus Oxygen Venturi in Severe Acute Respiratory Failure in Pneumonia
Pneumonia · Respiratory Insufficiency
Primary: to Evaluate the Efficacy of CPAP (Group A) in Comparison With Oxygen Therapy With Venturi Mask (Group B, Standard Therapy) in Terms of Achievement of Criteria for…
N/A N=40 A Comparison of the Detection of Hypoventilation During Deep Sedation Utilizing Nasal End Title CO@ Versus Transcutaneous CO2 Measurement Techniques
Surgery · Hypoventilation
Primary: TcCo2 vs PACo2 Difference — 3.2 mmHG