Phase 4 N=143 Ketamine Versus Etomidate for Rapid Sequence Intubation
Airway Control · Anesthesia · Intubation
Primary: SOFA Score — 6.5; 7 units on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=394 McGrath Videolaryngoscopy and Direct Laryngoscopy Rapid Sequence Intubation
Surgery
Primary: Visualization of the Vocal Cords — 90; 85; 63; 67 Participants — p=0.26
Phase 4 N=154 Intubation Conditions Achieved With Rapid Co-administration of Rocuronium and Propofol Versus Classical Induction
Anesthesia
Primary: The Total Time Between Laryngoscope Insertion Into Mouth and the Onset of Ventilation After Tracheal Intubation — 30.0; 33.0 seconds
N/A N=206 EmergeNcy Department Apneic Oxygenation Versus Usual Care During Rapid Sequence Intubation
Diffuse Apneic Oxygenation
Primary: Mean (Average) Arterial Oxygen Saturation — 92; 93 Percent Saturation (SpO2)
Phase 4 N=420 Succinylcholine Versus Rocuronium for Emergency Intubation in Intensive Care
Intubation
Primary: Number of Participants Exhibiting Desaturation >5% — 73; 66 participants
Phase 4 N=428 Evaluating the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence Intubation
Intubation Complication
Primary: Hemodynamic Effect as Measured by Systolic Blood Pressure Before and After RSI — 138.04; 132.39; 139.09; 130.09 mmHg
N/A N=1,301 Pragmatic Trial Examining Oxygenation Prior to Intubation
Acute Respiratory Failure
Primary: Incidence of Hypoxemia — 57; 118 Participants
Phase 4 N=2,367 Randomized Trial of Sedative Choice for Intubation
Acute Respiratory Failure
Primary: All-cause, 28-day, In-hospital Mortality — 330; 345 Participants
N/A N=64 Tracheal Intubation With the Rigid Tube for Laryngoscopy- a New Method
Intubation;Difficult
Primary: Time to Tracheal Intubation With the Rigid Tube — 50.5 seconds
N/A N=41 RIFL (Rigid and Flexing Laryngoscope) vs. Fiberoptic Bronchoscope
Intubation; Difficult
Primary: Time Until Proper Endotracheal Tube Placement — 49; 64 seconds
N/A N=51 Evaluation of the Rapid Airway Management Positioner
Endotracheal Intubation · Rapid Airway Management Positioner
Primary: Ease of Mask Ventilation as Assessed by Han Class — 15; 24; 18; 15 participants — p=0.0003
Phase 4 N=45 Premedication for Non-Emergency Endotracheal Intubation In the NICU
Respiratory Distress Syndrome
Primary: Present the Percentage of Participants With an Excellent Ease of Intubation Rating — 91; 17 % reported as excellent
Phase 4 N=337 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation
Acute Respiratory Failure · Intubation Complication
Primary: Number of Participants With Cardiovascular Collapse — 33; 31 Participants
N/A N=30 Evaluation of Etomidate on Adrenal Function in Trauma Patients
Adrenal Insufficiency
Primary: Cortisol Levels Pre and Post Rapid Sequence Induction and Cortisol Stimulation Test
N/A N=170 Intubating Conditions of Neuromuscular Blockade
Endotracheal Intubation
Primary: Number of Subjects With Optimal Intubating Conditions — 61; 47 Participants — p=0.036
N/A N=150 Facilitating EndotracheaL Intubation by Laryngoscopy Technique and Apneic Oxygenation Within the Intensive Care Unit: The FELLOW Study
Respiratory Failure
Primary: Successful First Attempt at Endotracheal Intubation (Defined by Confirmed Placement of an Endotracheal Tube in the Trachea During First Laryngoscopy Attempt) After…
N/A N=164 Soiled Airway Tracheal Intubation and the Effectiveness of Decontamination by Paramedics
Airway Management · Intubation, Intratracheal · Laryngoscopy
Primary: Difference in First-pass Intubation Success Rates Before and After SALAD Training — 44; 74 Participants
Phase 4 N=61 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation
Respiratory Distress Syndrome, Newborn
Primary: Rate of Failure of Surfactant Therapy, Either Early (Need for Mechanical Ventilation Within 1 Hour), or Late (FiO2 > 0.60 to Maintain Target SpO2, or Second Dose of…
Phase 4 N=801 Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial
Cardiopulmonary Arrest · Respiratory Arrest
Primary: Survival at Day 7 — 306; 336 Participants
N/A N=122 The Effect of Etomidate on Patient Outcomes After Single Bolus Doses
Sepsis · Trauma
Primary: Length of Stay — 9.5; 7.3 days
N/A N=1,420 DirEct Versus VIdeo LaryngosCopE Trial
Acute Respiratory Failure
Primary: Number of Intubations With Successful Intubation on the First Attempt — 600; 504 Participants
Phase 2 N=149 Aerosolized Surfactant in Neonatal RDS
Respiratory Distress Syndrome, Newborn
Primary: Number of Participants With Adverse Events as a Measure of Safety and Feasibility — 3; 8; 4; 12 Participants
N/A N=11 Sedation in Patients at Risk for Upper Airway Collapse
Obstructive Sleep Apnea
Primary: Respiratory Disturbance Index — 57.52; 21.32 events per hour
N/A N=68 Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses
Postoperative Pain
Primary: EC50 for Successful Intubation in Each Groups — 3.00; 2.00; 1.29 vol%
Phase 4 N=79 Use of Sugammadex for Reversal of Paralysis in Microlaryngoscopy
Microlaryngoscopy · Rigid Bronchoscopy
Primary: Time to Extubation After End of Procedure — 11.06; 10.36 Minutes
N/A N=60 Comparison of GlideScope-Specific Rigid Stylet to Standard Malleable Stylet for GlideScope Intubation by Novice Operators
Airway
Primary: Time to Intubation (Seconds) — 60; 61 seconds
Phase 4 N=102 Propofol for Pediatric Tracheal Intubation With Deep Anesthesia During Sevoflurane Induction
Anesthesia Intubation Complication
Primary: Estimated Propofol Doses Producing 50% Excellent Intubation Conditions — 1.48; 0.00; 0.07; 2.35 mg/kg
Phase 3 N=160 Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial
Critical Illness
Primary: Mean Arterial Pressure — 82.8; 80.9; 81.7; 77.6 mm Hg — p=0.385
N/A N=751 Protocolized Post-Extubation Respiratory Support Study
Mechanical Ventilation Complication · Acute Respiratory Failure · Intubation Complication
Primary: Reintubation — 57; 52 Participants
Phase 4 N=60 Comparing Hemodynamic Changes for Intubation With Shikani Intubating Stylet and Macintosh Laryngoscope
Anesthesia
Primary: Heart Rate and Blood Pressure Double Product — 9114; 8804 (beats/minute)*mmHg