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Addictions

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Addictions

30 trials tracked for Addictions: 4 in phase 3 or 4 and 1 with published results. The most-cited published study has 40 citations.

30Trials tracked

4Phase 3 & 4

0Recruiting

1With published results

Phase distribution

Phase 4 1 Phase 3 3 Phase 2 4 Phase 1 2 Other / NA 20

Phase 3 The Role of Sleep in the Treatment of Cannabis Use Disorders Completed · 40 cited
Phase 4 A Randomized Double-Blind Controlled Trial of Creatine in Female Methamphetamine Users Completed
Phase 3 Perioperative Pregabalin in Ureteroscopy Completed
Phase 3 Evaluating Improvement Strategies in Addiction Treatment Completed
Phase 2 N-acetylcysteine in the Treatment of PTSD and Addiction Completed
Phase 2 Genetic Effects on Dopamine Response to an Opiate Completed

Show 24 more trials

Phase 2 Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD) Completed
Phase 2 Bilateral Prefrontal Modulation in Crack-cocaine Addiction Completed
Phase 1 Boost Study 31380 (mHealth) Completed
Phase 1 Safety and Tolerability of Cannabidiol Among Persons With Opioid Use Disorder Receiving Methadone or Buprenorphine Completed
N/A Cognitive Enhancement as a Target for Cocaine Pharmacotherapy Completed
N/A Clinical Trial of Smoking Cessation Mobile Phone Program Completed
N/A Leveraging Technology to Address Unhealthy Drug Use in Primary Care Settings Completed
N/A An Addiction-Based Mobile Health Weight Loss Intervention With Coaching Completed
N/A Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3 Completed
N/A Providing Mental Health Precision Treatment Completed
N/A Journaling and Addiction Recovery: Piloting "Positive Recovery Journaling" Completed
N/A Effects of MDMA on Social and Emotional Processing Completed
N/A Mobile Continuing Care Approach for Youth Completed
N/A Evaluation of a Health Plan Initiative to Mitigate Chronic Opioid Therapy Risks Completed
N/A Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD Completed
N/A Cognitive Effects of Atomoxetine in Humans: Genetic Moderators Completed
N/A Bilateral Prefrontal Modulation in Alcoholism Completed
N/A Innovative Digital Therapeutic for Smoking Cessation Completed
N/A Cannabidiol and Emotional Stimuli Completed
N/A Healing Lodge First Face Training Evaluation Study Completed
N/A Piloting "Positive Peer Journaling" a Journaling Practice to Support Recovery From Addiction Completed
N/A A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses Completed
N/A QuitFast: Evaluating Transcranial Magnetic Stimulation as a Tool to Reduce Smoking Directly Following a Quit Attempt Completed
N/A Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings Completed

Showing the 30 most-cited and recently-updated of 30 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Addictions: what the trials found

Established evidence indicates that Positive Peer Journaling (PPJ) is associated with specific outcomes in patient well-being and engagement. Patients utilizing PPJ reported satisfaction with life scores of 20.5 and 18.6 at 2 weeks, 19.4 and 18.8 at 4 weeks, and 21 and 21.2 at 8 weeks ¹⁶. Additionally, patients in the PPJ group demonstrated a 78.3% attendance rate for group sessions ²⁰.

Other established interventions include learning sessions ⁵, zolpidem extended-release which showed sleep efficiency of 78% and 74% ³, and pregabalin (300mg) which resulted in Visual Analog Scale of Pain scores of 3.7 and 2.0, with Watson Clock Drawing Test scores of 1.8 and 1.8 ⁴.

Recent results — preliminary, needs further review

Isoniazid was evaluated for TB Treatment Completion Rates in a prison setting (p=0.08) ¹.
CBD Day 1 was assessed in a Phase 1 trial ¹⁰.
First Face for Mental Health was evaluated in a study of 92 participants ¹².

For the clinician treating this condition

Positive Peer Journaling (PPJ) is associated with consistent levels of life satisfaction over an 8-week period and high rates of group session attendance.
Pregabalin at 300mg was shown to impact pain scores and cognitive testing as measured by the Watson Clock Drawing Test.

AI synthesis of 8 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.