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Home › Conditions › Anal Cancer

Anal Cancer

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Anal Cancer

34 trials tracked for Anal Cancer: 4 in phase 3 or 4 and 3 with published results. The most-cited published study has 520 citations.

34Trials tracked
4Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 3 4 Phase 2 18 Phase 1 1 Other / NA 11
  1. Phase 3 Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions Completed · 520 cited
  2. Phase 3 Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With Anal Neoplasia Completed · 62 cited
  3. Phase 3 Efficacy, Immunogenicity, and Safety Study of the 9vHPV Vaccine in Japanese Males (V503-064) Completed · 13 cited
  4. Phase 3 Multivalent HPV (Human Papillomavirus) Vaccine Study in 16- to 26-Year Old Men and Women (V503-003) Completed
  5. Phase 2 Cidofovir in Treating HIV-Infected Patients With High-Grade Squamous Intraepithelial Lesions of the Skin Near the Anus Completed
  6. Phase 2 Trial To Test Safety And Efficacy Of Vaccination For Incurable HPV 16-Related Oropharyngeal, Cervical And Anal Cancer Completed
Show 28 more trials
  1. Phase 2 A Phase 2 Study of Axalimogene Filolisbac (ADXS11-001) in Participants With Carcinoma of the Anorectal Canal Completed
  2. Phase 2 A Study of INCMGA00012 in Squamous Carcinoma of the Anal Canal Following Platinum-Based Chemotherapy (POD1UM-202) Completed
  3. Phase 2 Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers Completed
  4. Phase 2 M7824 in Subjects With HPV Associated Malignancies Completed
  5. Phase 2 T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers Completed
  6. Phase 2 Oral Cryotherapy Plus Acupressure and Acupuncture Versus Oral Cryotherapy for Decreasing Chemotherapy-Induced Peripheral Neuropathy From Oxaliplatin-Based Chemotherapy in Patients With Gastrointestinal Cancer Completed
  7. Phase 2 Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer Completed
  8. Phase 2 Treatment of Anal High-grade Squamous Intraepithelial Lesions (HSIL) Through Use of a Chinese Herbal Topical Cream Completed
  9. Phase 2 Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer Completed
  10. Phase 2 Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial Completed
  11. Phase 2 Vaccine Therapy in Preventing Human Papillomavirus Infection in Young HIV-Positive Male Patients Who Have Sex With Males Completed
  12. Phase 2 VGX-3100 Delivered Intramuscularly (IM) Followed by Electroporation (EP) for the Treatment of HPV-16 and/or HPV-18 Related Anal or Anal/Peri-Anal, High Grade Squamous Intraepithelial Lesion (HSIL) in Individuals Seronegative for Human Immunodeficiency Virus (HIV)-1/2 Completed
  13. Phase 2 Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer Completed
  14. Phase 2 [F-18] Fluorothymidine PET/CT Imaging for Pelvic Cancers Completed
  15. Phase 2 Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer Completed
  16. Phase 2 Pembrolizumab in Metastatic Anal Cancer Completed
  17. Phase 1 SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas Completed
  18. N/A Anal HPV Tests in Screening for Cell Changes in the Anus in Patients With HIV Completed
  19. N/A A Message Framing Intervention for Increasing Parental Acceptance of Human Papillomavirus Vaccination Completed
  20. N/A The Prevent Anal Cancer Palpation Study Completed
  21. N/A Men's Beliefs About Associations Between HPV, Cancers, and HPV Vaccination Completed
  22. N/A Programs To Support You During Chemotherapy Completed
  23. N/A A Chatbot Intervention for Reducing HPV Vaccine Hesitancy Completed
  24. N/A The Self-Sampling Pilot Study Completed
  25. N/A Cancer in Patients With Gabapentin (GPRD) Completed
  26. N/A Use of a Screening Tool to Describe HIV-Related Cancer Burden and Patient Characteristics in the AMC Completed
  27. N/A Open Pilot Trial of a Mind-Body Sexual Well-Being Intervention for Female GI Cancer Survivors Completed
  28. N/A The Prevent Anal Cancer Self-Swab Study Completed

Showing the 34 most-cited and recently-updated of 34 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Anal Cancer: what the trials found

Immunotherapy and pharmacological interventions have shown measurable effects on symptoms and disease markers. Imiquimod was associated with a reduction in Physical Symptom Scores from baseline to 4 weeks post-randomization 1.

Vaccination strategies show significant efficacy in reducing HPV-related infections and establishing immunity. V503 significantly reduced the combined incidence of HPV 6/11/16/18-related anogenital persistent infections compared to the control group (0.2 vs 2.2; p<0.001) 3. The 9vHPV vaccine demonstrated significant geometric mean titers (GMTs) against the targeted HPV types 4.

Cetuximab was evaluated for local and locoregional outcomes. There was no statistically significant difference in the local failure rate at 3 years between groups 17. However, a locoregional failure rate of 20% was observed in one cohort, with a corresponding EORTC Global Quality of Life score of 78.9 at 1 year 18.

Other established interventions include Fludarabine [15, 16] and clinical observation, which showed a 40% proportion of patients with high-grade anal intraepithelial neoplasia at 1 year 2.

Recent results — preliminary, needs further review

  • Acoupuncture therapy was evaluated for chemotherapy-induced peripheral neuropathy (CIPN) and associated symptoms (pain, fatigue, nausea, anxiety) over a 3-month period 5.

For the clinician treating this condition

  • Imiquimod is associated with a reduction in physical symptom scores in the early post-treatment period 1.
  • V503 and 9vHPV vaccines are established for reducing HPV-related infections and establishing high geometric mean titers against specific HPV types [3, 4].
  • Cetuximab shows no significant difference in local failure rates at 3 years 17, while locoregional failure rates and quality of life scores were documented in related cohorts 18.

AI synthesis of 7 cited trials, updated Oct 17, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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