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Home › Conditions › bone metastases

Bone metastases

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for bone metastases

20 trials tracked for bone metastases: 8 in phase 3 or 4 and 4 with published results. The most-cited published study has 440 citations.

20Trials tracked
8Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 3 8 Phase 2 6 Phase 1 1 Other / NA 5
  1. Phase 3 Denosumab Compared to Zoledronic Acid in the Treatment of Bone Disease in Patients With Multiple Myeloma Completed · 440 cited
  2. Phase 3 A Randomized Trial Evaluating Rapid Delivery of Dose Escalated Hypofractionated Radiotherapy for Patients Diagnosed With Bone Metastases for Effective Palliation of Symptoms Completed · 226 cited
  3. Phase 3 Dexamethasone vs Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases Completed · 170 cited
  4. Phase 3 QUILT-2.014: Gemcitabine and AMG 479 in Metastatic Adenocarcinoma of the Pancreas Completed · 164 cited
  5. Phase 3 Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Men With Hormone-refractory Prostate Cancer Completed
  6. Phase 3 A Phase III Study of Radium-223 Dichloride in Patients With Symptomatic Hormone Refractory Prostate Cancer With Skeletal Metastases Completed
Show 14 more trials
  1. Phase 3 Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma. Completed
  2. Phase 3 A Study Comparing Denosumab vs. Zoledronic Acid for the Treatment of Bone Metastases in Breast Cancer Subjects. Completed
  3. Phase 2 Magnetic Resonance Imaging in Measuring the Effect of Cabozantinib in Patients With Castrate Resistant Prostate Cancer Completed
  4. Phase 2 Dasatinib in Combination With Zoledronic Acid for the Treatment of Breast Cancer With Bone Metastasis Completed
  5. Phase 2 A Study of Alpharadin With Docetaxel in Patients With Bone Metastasis From Castration-Resistant Prostate Cancer (CRPC) Completed
  6. Phase 2 Sipuleucel-T With or Without Radiation Therapy in Treating Patients With Hormone-Resistant Metastatic Prostate Cancer Completed
  7. Phase 2 Sm-EDTMP and Autologous Peripheral Blood Stem Cell Transplantation for Breast Cancer Patients With Bone Only Metastases Completed
  8. Phase 2 Open Label Extension In Cancer Patients Completed
  9. Phase 1 A Study to Determine the Safety, Tolerability, Pharmacokinetics and Dynamic Effects of Different Doses of the Study Drug EMD 525797 in Prostate Cancer Completed
  10. N/A ExAblate (MRgFUS) Treatment of Metastatic Bone Tumors for the Palliation of Pain Completed
  11. N/A EPIBONE Study: a Prospective Study on Feasibility, Safety and Accuracy Completed
  12. N/A Aspirin and Compression Devices for VTE Prophylaxis in Orthopaedic Oncology Completed
  13. N/A Rapid Radiation Therapy for Painful Osseous Metastatic Disease Completed
  14. N/A A Pilot Study to Enhance F18 FDG-PET Imaging of Prostate Cancers With the Metabolic Inhibitor Ranolazine Completed

Showing the 20 most-cited and recently-updated of 20 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Palliative care consultation for bone metastases radiotherapy patients shows no outcome data in protocol
Oncology RCT
Palliative care consultation for bone metastases radiotherapy patients shows no outcome data in protocol Hospital palliative care teams may improve satisfaction for advanced cancer patients
This is a study protocol for a randomized controlled trial in patients with bone metastases referred for radiotherapy. The intervention is c…
A hospital trial suggests that adding palliative care consultations could boost satisfaction for patients with bone metastases and advanced …
May 23, 2026
CT-Based Radiomics Model Predicts Pain Relief After Radiotherapy for Bone Metastases
Oncology Guideline
CT-Based Radiomics Model Predicts Pain Relief After Radiotherapy for Bone Metastases AI Predicts Who Will Get Pain Relief from Radiation
This retrospective dual-center study developed a CT-based radiomics model (KNN) to predict pain relief after palliative radiotherapy in 134 …
You’re sitting in the oncology clinic, tired from weeks of pain.
Frontiers Apr 24, 2026
225Ac-DOTA-IBA shows pain relief and imaging responses in bone metastases preliminary study
Oncology
225Ac-DOTA-IBA shows pain relief and imaging responses in bone metastases preliminary study Small preliminary study shows promising pain relief with new bone cancer treatments
A preliminary study of 14 patients with bone metastases found that 225Ac-DOTA-IBA at 3.7 MBq per cycle led to pain relief in 92.9% after the…
New bone cancer drugs relieved pain in 93% of patients and improved daily function with no severe side effects in this early study.
Apr 14, 2026

Questions about bone metastases

Will seeing a palliative care team help my bone metastases pain?

Seeing a palliative care team can help manage bone metastases pain by improving satisfaction with care and reducing symptom burden through a multidisciplinary approach.

Full answer →