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Cervical Adenocarcinoma

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Cervical Adenocarcinoma

18 trials tracked for Cervical Adenocarcinoma: 4 in phase 3 or 4 and 3 with published results. The most-cited published study has 1504 citations.

18Trials tracked
4Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 3 4 Phase 2 12 Phase 1 2
  1. Phase 3 Paclitaxel and Cisplatin or Topotecan With or Without Bevacizumab in Treating Patients With Stage IVB, Recurrent, or Persistent Cervical Cancer Completed · 1,504 cited
  2. Phase 3 Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel in Patients With Locally Advanced Cervical Cancer Completed · 194 cited
  3. Phase 3 Radiation Therapy With or Without Chemotherapy in Patients With Stage I-IIA Cervical Cancer Who Previously Underwent Surgery Completed · 41 cited
  4. Phase 3 Comparison of Four Combination Chemotherapy Regimens Using Cisplatin in Treating Patients With Stage IVB, Recurrent, or Persistent Cancer of the Cervix Completed
  5. Phase 2 Oxaliplatin and Paclitaxel in Treating Patients With Locally Recurrent or Metastatic Cervical Cancer Completed
  6. Phase 2 Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer Completed
Show 12 more trials
  1. Phase 2 ABI-007 in Treating Patients With Persistent or Recurrent Cervical Cancer Completed
  2. Phase 2 Vaccine Therapy in Treating Patients With Persistent or Recurrent Cervical Cancer Completed
  3. Phase 2 Bevacizumab, Radiation Therapy, and Cisplatin in Treating Patients With Previously Untreated Locally Advanced Cervical Cancer Completed
  4. Phase 2 Temsirolimus in Treating Patients With Cervical Cancer That Is Recurrent, Locally Advanced, Metastatic, or Cannot Be Removed By Surgery Completed
  5. Phase 2 Ipilimumab in Treating Patients With Metastatic or Recurrent Human Papilloma Virus-Related Cervical Cancer Completed
  6. Phase 2 Fludeoxyglucose (FDG) F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer Completed
  7. Phase 2 Sunitinib Malate in Treating Patients With Uterine Cervical Cancer That is Stage IVB, Recurrent, or Cannot Be Removed By Surgery Completed
  8. Phase 2 FDG and FMISO PET Hypoxia Evaluation in Cervical Cancer Completed
  9. Phase 2 Atezolizumab and Bevacizumab in Treating Patients With Recurrent, Persistent, or Metastatic Cervical Cancer Completed
  10. Phase 2 Brivanib Alaninate in Treating Patients With Persistent or Recurrent Cervical Cancer Completed
  11. Phase 1 Axalimogene Filolisbac (ADXS11-001) High Dose in Women With Human Papillomavirus (HPV) + Cervical Cancer Completed
  12. Phase 1 Atezolizumab Before and/or With Chemoradiotherapy in Immune System Activation in Patients With Node Positive Stage IB2, II, IIIB, or IVA Cervical Cancer Completed

Showing the 18 most-cited and recently-updated of 18 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Cervical Adenocarcinoma: what the trials found

Clinical investigations into cervical adenocarcinoma have evaluated several systemic therapies, including Bevacizumab and Atezolizumab. In a Phase 3 trial of Bevacizumab (N=452), the study was established as part of the standard evidence base 1. A separate Phase 2 trial evaluating Bevacizumab (N=60) reported that zero subjects experienced treatment-related serious adverse events or Grade 3+ adverse events within the first 90 days of treatment 16.

Atezolizumab was evaluated in two trials. In a Phase 2 study (N=11), 36.4% of participants experienced adverse events 5. A Phase 1 trial (N=40) reported that 21.43% of participants experienced dose-limiting toxicities, while the incidence of Grade 3 or higher adverse events during the treatment period ranged from 0% to 6% across various cohorts; this study also recorded disease-free survival at 2 years as 68.4% and 52.9% respectively 18.

Chemotherapeutic agents including Carboplatin and Cisplatin have been studied in Phase 3 trials. For Carboplatin (N=926), the reported 5-year overall survival rates were 71% and 72%, while 5-year progression-free survival rates were 62% and 63%; Grade 3 or higher adverse events in the first year ranged from 1% to 14% 2. For Cisplatin, Phase 3 trials were conducted with cohorts of N=340 3 and N=513 4.

Recent results — preliminary, needs further review

  • Ipilimumab (N=42) - Not yet corroborated.
  • Attenuated Live Listeria Encoding HPV 16 E7 Vaccine ADXS11-001 (N=54) - Not yet corroborated.
  • Paclitaxel Albumin-Stabilized Nanoparticle Formulation (N=37) - Not yet corroborated.
  • Filgrastim (N=27) - Not yet corroborated.
  • Brivanib Alaninate (N=31) - Not yet corroborated.

For the clinician treating this condition

  • Bevacizumab is established in the treatment landscape, with one study reporting no Grade 3+ adverse events within the first 90 days of initiation [1, 16].
  • Atezolizumab shows a range of tolerability; while 36.4% of patients experienced adverse events in a small cohort, dose-limiting toxicities were observed in approximately 21.43% of participants in another study [5, 18].
  • Chemotherapy options include Carboplatin and Cisplatin, with Carboplatin showing 5-year progression-free survival rates between 62% and 63% [2, 3, 4].

AI synthesis of 7 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.