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Cholera

Part of Vibriosis

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Cholera

8 trials tracked for Cholera: 4 in phase 3 or 4 and 3 with published results. The most-cited published study has 197 citations.

8Trials tracked
4Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 3 4 Phase 2 3 Other / NA 1
  1. Phase 3 Safety and Efficacy Challenge Study of Live Oral Cholera Vaccine Candidate,PXVX0200, to Prevent Cholera Completed · 197 cited
  2. Phase 3 A Phase 3 Lot to Lot Consistency Study of Live Oral Cholera Vaccine, PXVX0200 in Healthy Adults Completed · 21 cited
  3. Phase 3 A Study of Live Oral Cholera Vaccine, PXVX200 in Healthy Older Adults Completed · 12 cited
  4. Phase 3 Next Generation ORS: Comparing ORS With Calcium vs Standard ORS in Reducing Severity of Acute Watery Diarrhea Completed
  5. Phase 2 Cholera Anti-Secretory Treatment Trial Completed
  6. Phase 2 Assessment of a Novel Fixed-dose Combination (FDC) Drug VR-AD-1005 for the Treatment of Acute Watery Diarrhea in Cholera Completed
Show 2 more trials
  1. Phase 2 Immunologic Responses to a Live Attenuated Oral Cholera Vaccine Completed
  2. N/A Water, Sanitation, and Hygiene Mobile Health Messages as an Innovative Tool to Facilitate Behavior Change Completed

Showing the 8 most-cited and recently-updated of 8 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Questions about Cholera

What interventions were used during the cholera outbreak in Zimbabwe?

Zimbabwe's cholera response combined water, sanitation, and hygiene improvements with mass oral vaccination campaigns to control outbreaks.

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Can the cholera vaccine be used as a reactive campaign?

Yes, the cholera vaccine is used as a reactive campaign to stop outbreaks, with studies showing it reduces transmission and cases when combined with water and hygiene measures.

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Did water and hygiene help stop the cholera outbreak in Zimbabwe?

Water, sanitation, and hygiene (WASH) interventions were a key part of stopping the 2018 cholera outbreak in Zimbabwe, alongside vaccination and detection efforts.

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What are the CDC 2022 recommendations for cholera vaccine use?

The CDC 2022 recommendations advise using the oral cholera vaccine (CVD 103-HG R) for travelers to areas with cholera outbreaks or endemic areas, particularly those at higher risk for severe disease.

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Did the oral cholera vaccine reduce transmission in Malawi?

A 2022-2023 vaccination campaign in Blantyre, Malawi, reduced cholera transmission by 53.5% to 62.1%.

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See all 5 questions about Cholera →