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Chronic constipation

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for chronic constipation

74 trials tracked for chronic constipation: 32 in phase 3 or 4 and 4 with published results. The most-cited published study has 530 citations.

74Trials tracked

32Phase 3 & 4

0Recruiting

4With published results

Phase distribution

Phase 4 14 Phase 3 18 Phase 2 20 Other / NA 22

Phase 4 Bowel Function After Minimally Invasive Hysterectomy Completed · 530 cited
Phase 3 Study Evaluating Long-Term Safety of MOA-728 in Participants With Opioid-Induced Constipation Completed · 153 cited
Phase 3 Safety and Efficacy of Linaclotide in Patients With Chronic Constipation and Prominent Abdominal Bloating Completed · 80 cited
Phase 4 Does a Preoperative Bowel Regimen Change Time to First Bowel Movement After Robotic Sacral Colpopexy Completed
Phase 4 Safety and Efficacy of Lubiprostone in Pediatric Patients With Constipation Completed
Phase 4 Effects of Lubiprostone on Small Bowel and Colonic Bacteria: A Correlation Study With Segmental and Whole Gut Transit Completed

Show 44 more trials

Phase 4 Study to Gather Information on the Acceptability of a New Flavor System With Increasing Levels of 2, 4, 6 g or Higher of Mannitol for PEG 3350 in Subjects Having Infrequent Bowel Movements. Completed
Phase 4 Trial of Alvimopan in Major Spine Surgery Completed
Phase 4 Lubiprostone in Patients With Multiple Sclerosis Associated Constipation Completed
Phase 4 Study to Investigate Prucalopride vs. Polyethylene Glycol 3350 on Colon Activity Completed
Phase 4 Study Comparing PEG 3350 Laxative to Placebo in the Treatment of Occasional Constipation (Study CL2007-12)(P08216) Completed
Phase 4 A Preference Study Comparing Kristalose® and Liquid Lactulose Completed
Phase 4 Evaluation of Long-term Prucalopride Treatment With Chronic Constipation in Subjects Aged ≥ 18 Years Completed
Phase 4 Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS) Completed
Phase 4 Effect of Octreotide on the Colonic Motility in Pediatric Patients Completed
Phase 4 The Effectiveness of Lubiprostone in Constipated Diabetics Completed
Phase 3 An Open-label, Long-term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation Completed
Phase 3 Lubiprostone for the Treatment of Chronic Idiopathic Constipation Completed
Phase 3 An Open-Label, Long-Term Safety Study of Linaclotide in Patients With Chronic Constipation or Irritable Bowel Syndrome With Constipation Completed
Phase 3 Lubiprostone for Chronic Idiopathic Constipation Treatment Completed
Phase 3 Study Evaluating the Efficacy and Safety of Subcutaneous Methylnaltrexone (MOA-728) for the Treatment of Opioid-Induced-Constipation Completed
Phase 3 BLI400-302: A Safety and Efficacy Evaluation of BLI400 Laxative in Constipated Adults Completed
Phase 3 An Open Label Study of Chronic Use of BLI400 Laxative in Constipated Adults Completed
Phase 3 A Safety and Efficacy Evaluation of BLI801 Laxative in Adults Experiencing Non-Idiopathic Constipation Completed
Phase 3 Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation Completed
Phase 3 Trial of Linaclotide in Patients With Chronic Constipation Completed
Phase 3 Efficacy and Safety of Acupuncture for Functional Constipation Completed
Phase 3 Phase III, Randomized, Double-Blind, Placebo-Controlled, Trial of Linaclotide Administered to Patients With Chronic Constipation Completed
Phase 3 Study Evaluating Subcutaneous MOA-728 for the Treatment of Opioid-Induced Constipation (OIC) in Subjects With Chronic Non-Malignant Pain Completed
Phase 3 Dulcolax vs Placebo in Functional Constipation Completed
Phase 3 B. Lactis HN019 for Functional Constipation Completed
Phase 3 Lubiprostone and Mucus Secretion in Patients With Chronic Constipation Completed
Phase 2 Study Evaluating MOA-728 Oral for the Treatment of OIBD in Subjects With Chronic Non-Malignant Pain Completed
Phase 2 Evaluation of Safety and Tolerability of ENT-01 for the Treatment of Parkinson's Disease Related Constipation Completed
Phase 2 Study of Elobixibat (A3309) in Patients With Chronic Idiopathic Constipation Completed
Phase 2 An Effectiveness and Safety Study of Chinese Herbal Medicine for Functional Constipation Completed
Phase 2 Orally Administered ENT-01 for Parkinson's Disease-Related Constipation (KARMET) Completed
Phase 2 A Clinical Standardization Study of the Preferred Acupuncture Treatment Protocol to Treat Functional Constipation Completed
Phase 2 The Efficacy and Safety Study of Electro-acupuncture for Severe Chronic Functional Constipation Completed
Phase 2 S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis Completed
Phase 2 Effects of Alpha-1 Antagonist, Stress and Relaxation on Anorectal Functions Completed
Phase 2 Laxative Effectiveness of a Phytotherapeutic Tea Completed
Phase 2 A Dose Determination Study of Chinese Herbal Medicine for Functional Constipation Completed
Phase 2 Safety and Tolerability of Oral Polyethylene Glycol (PEG 3350) Solution in Participants With Constipation (MK-8114-003) Completed
Phase 2 Post-Operative Constipation Following Total Knee Arthroplasty Completed
Phase 2 Use of Pyridostigmine for Constipation in Diabetics Completed
Phase 2 Dose-Finding Trial of Polyethylene Glycol 3350 Laxative Plus Electrolytes for the Treatment of Constipation (Protocol P07515) Completed
Phase 2 Study Evaluating Oral MOA-728 For The Treatment Of OIBD In Subjects With Chronic Non-Malignant Pain Completed
Phase 2 Dose-range-finding, Phase 2 Trial of Oral Linaclotide Acetate Administered to Patients With Chronic Constipation Completed
Phase 2 Evaluation of the Efficacy and Safety of ADL5945 Once Daily for the Treatment of Opioid-induced Constipation in Adults Taking Opioid Therapy for Chronic Noncancer Pain Completed

Showing the 50 most-cited and recently-updated of 74 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.