Research across Kidney Diseases
Related studies from across the Kidney Diseases family.
CKD-MBD care should shift from biochemical targets to phenotype-informed, outcome-oriented management
New approach to managing bone and vascular health in kidney disease
This narrative review argues that chronic kidney disease-mineral and bone disorder (CKD-MBD) management should move beyond biochemical targe…
Doctors are pushing for a new way to treat bone and blood vessel issues in patients with chronic kidney disease.
Kidney and brain share common pathways linking renal dysfunction to neurological impairment
Kidney and Brain Health Share Linked Biological Pathways
This narrative review explores the bidirectional relationship between renal and neurological health. It details how shared vascular, metabol…
Research shows that kidney and brain health are linked through shared metabolic and immune pathways, affecting how patients recover from inj…
H. pylori eradication linked to lower proteinuria and reduced CKD risk in meta-analysis
Treating a common stomach bacteria may help manage kidney disease
This meta-analysis examines the association between Helicobacter pylori eradication and kidney outcomes in patients with kidney disease or p…
Treating a common stomach infection called H. pylori may lower protein levels in the urine and reduce the risk of chronic kidney disease.
Intermittent Hemodialysis Falls Short of Continuous Therapy in Critically Ill AKI Trial
Trial shows continuous renal-replacement therapy may reduce kidney injury mortality
In critically ill adults with acute kidney injury, intermittent hemodialysis did not prove noninferior to continuous therapy and was linked …
A trial of 554 critically ill adults found that continuous renal-replacement therapy was associated with lower mortality rates than intermit…
nsMRAs reduce UACR and systolic BP in patients with diabetic kidney disease
New medication class shows promise for diabetic kidney disease
This meta-analysis of 15,143 patients found that nsMRAs reduced log-transformed UACR by 0.36 mg/g and systolic BP by 4.72 mmHg in patients w…
A new class of drugs may lower blood pressure and protein in the urine for people with diabetic kidney disease, though some risks exist.
Metabolic profiles and specific metabolites serve as potential biomarkers for diabetic kidney disease progression
Metabolites May Help Identify New Pathways in Diabetic Kidney Disease
This systematic review synthesizes the roles of metabolites as signaling hubs and substrates for epigenetic modifications in diabetic kidney…
New research identifies how specific metabolites act as signaling hubs that could help doctors better predict and treat diabetic kidney dise…
Monocyte and macrophage sensing of calciprotein particles triggers inflammasome activation and interleukin-1β release
Immune Cells and Calcium Particles May Drive Damage in Kidney Disease
This mini-review synthesizes evidence regarding how monocytes and macrophages respond to calciprotein particles (CPPs). The review details m…
New research shows how certain immune cells react to calcium particles, potentially causing inflammation and tissue damage in kidney patient…
Unhealthy food environments and ultra-processed foods contribute to obesity and related cardiometabolic diseases
Food Environments Linked to Obesity and Type 2 Diabetes
This narrative review examines how food environment factors like accessibility and affordability influence the consumption of ultra-processe…
Unhealthy food environments and ultra-processed foods are linked to serious conditions like insulin resistance, heart disease, and chronic k…
suPAR predicts incident CKD and ESKD in adults with preserved kidney function
suPAR Levels May Predict Risk of Chronic Kidney Disease
This systematic review of 31,416 patients found that suPAR predicts incident CKD (OR 3.13) and ESKD (HR 1.53) in adults with preserved kidne…
A large review suggests that suPAR levels can help predict the risk of developing chronic kidney disease and end-stage kidney disease in som…
Resistance training improves eGFR in non-dialysis diabetic kidney disease while mind-body exercise reduces UAE
Specific types of exercise may help manage diabetic kidney disease
This systematic review and network meta-analysis of 1,746 patients found that resistance training significantly increased eGFR compared to u…
Different types of exercise, from resistance training to mind-body practices, show different benefits for managing diabetic kidney disease a…
RAAS inhibitors modulate inflammatory responses and oxidative stress across multiple chronic conditions
RAAS Inhibitors May Protect Organs Beyond Lowering Blood Pressure
This systematic review synthesizes the roles of ACEI, ARB, DRI, ARNI, and MRA in modulating inflammatory responses and oxidative stress. The…
New research suggests certain blood pressure medications may protect the heart, kidneys, and lungs by reducing inflammation and oxidative st…
Glutamine metabolism serves as a critical energy substrate and potential therapeutic target in AKI and CKD
Glutamine Metabolism May Offer New Insights for Kidney Disease
This narrative review explores the role of glutamine metabolism in acute kidney injury and chronic kidney disease. The authors suggest that …
New research into glutamine metabolism suggests potential new ways to manage and treat acute and chronic kidney diseases.