miR-155 overexpression is frequently associated with treatment resistance across 8 cancer types
miR-155 Expression Linked to Treatment Resistance in Various Cancers
This systematic review of 19 studies across 8 cancer types indicates that miR-155 overexpression is associated with treatment resistance in …
Research suggests that high levels of a specific molecule, miR-155, may be linked to how well certain cancers respond to treatment.
Melanoma cell subpopulations identified; EIF5A linked to poor outcomes in observational cohort
New Cell Types Found That Help Fight Melanoma
This observational study analyzed 70,760 cells from 11 samples and clinical specimens from seven patients, alongside the TCGA-SKCM cohort.
Some melanoma cells help your immune system fight the cancer, and a new study identifies seven major cell types linked to better outcomes.
Research across Cancer
Related studies from across the Cancer family.
Dual immune checkpoint inhibition provides durable intracranial progression-free survival in melanoma patients with brain metastases
Dual immune therapy shows promise for melanoma brain metastases
This meta-analysis of 3,518 patients with cutaneous or mucosal melanoma brain metastases indicates that dual immune checkpoint inhibition pr…
Combining two immune therapies may offer more durable results for patients with melanoma that has spread to the brain.
PD-1/PD-L1 inhibitors with SRS or FSRT achieve 87% one-year local control in brain metastases
Combining immunotherapy and radiation for brain metastases shows promise
This meta-analysis of 2587 patients with brain metastases evaluated the combination of PD-1/PD-L1 inhibitors with stereotactic radiosurgery …
A new analysis shows that combining specific immunotherapy drugs with radiation can help control brain tumors and manage side effects.
Genetic risk factors and a validated polygenic risk score identify melanoma risk loci
Genetic Risk Factors Linked to Melanoma Development Identified
This meta-analysis of 69,871 cases and 1,616,233 controls identifies 156 independent signals at 116 risk loci for cutaneous melanoma. The st…
Researchers identified over 150 genetic signals linked to melanoma, helping to better understand how genetics influence skin cancer risk.
CIC-Rearranged Intracranial Sarcoma: Local Control Achieved but Distant Spread Rapid Despite Multimodal Therapy
Rare brain tumor appears in patient with history of melanoma
This is a single-patient case report of a 36-year-old woman with a prior history of melanoma who developed an intracranial sarcoma. Gross to…
A 36-year-old woman with a history of melanoma developed a rare type of brain tumor called an intracranial sarcoma.
mRNA vaccines provide a clinically validated platform to induce durable anti-tumor immunity in solid tumors
mRNA Vaccines Show Potential for Treating Several Solid Tumors
This systematic review evaluates mRNA vaccines for melanoma, pancreatic cancer, and non-small cell lung cancer. The authors conclude that mR…
mRNA technology is being used to create cancer vaccines that may help patients with melanoma, pancreatic, and lung cancers by building lasti…
Artificial Intelligence Performance in Dermatoscopic Image Interpretation for Skin Cancer Diagnosis
AI Shows High Performance in Detecting Skin Cancer Images
A meta-analysis of 208 articles evaluates how AI compares to expert dermatoscopy in identifying melanoma and other common skin malignancies.
Artificial intelligence may improve the accuracy of diagnosing skin cancers like melanoma when analyzing specialized skin images.
Approximately 40% to 55% of patients with advanced melanoma exhibit primary resistance to PD-1 monotherapy
PD-1 Inhibitors Show Varying Resistance Rates in Advanced Melanoma
This systematic review examines resistance mechanisms to PD-1 and PD-L1 inhibitors in patients with advanced melanoma. It identifies primary…
New research identifies specific rates of initial and acquired resistance to PD-1 inhibitors in patients with advanced melanoma.
MITF E318K variant associated with significantly increased melanoma risk and high nevus burden
Specific gene variant linked to higher risk of multiple melanomas
This systematic review and meta-analysis of 8,606 melanoma patients and 17,953 controls identifies the MITF E318K variant as a moderate-pene…
A specific genetic variant called MITF E318K is linked to a significantly higher risk of developing multiple primary melanomas.
Melanoma Immunoediting Review Maps Elimination, Equilibrium, Escape and Drivers of Immunotherapy Resistance
Immune System Changes Drive Melanoma Growth and Treatment Resistance
This systematic review synthesizes the tumor immunoediting framework in melanoma, describing three sequential phases (elimination, equilibri…
New research highlights how the immune system's failure to eliminate melanoma cells leads to tumor growth and resistance to current therapie…
Medicinal plant extracts and phytochemicals show potential as multitargeted candidates for metastatic melanoma
Plant extracts show promise for treating advanced melanoma skin cancer
This narrative review explores the potential of medicinal plant extracts and isolated phytochemicals as multitargeted therapeutic candidates…
Certain medicinal plants and their natural compounds may offer a new way to target multiple pathways in advanced melanoma.
Self-administered ivermectin and fenbendazole in a patient with metastatic melanoma showed mixed radiographic and ctDNA responses
One man with melanoma tries antiparasitic drugs for his cancer
This case report describes a 74-year-old man with metastatic melanoma who self-administered ivermectin and fenbendazole. The patient experie…
A man with advanced melanoma saw a temporary drop in cancer markers after taking ivermectin and fenbendazole, but the results were mixed.
Encorafenib and Binimetinib Combination Therapy for Patients with BRAF Mutated Cutaneous Melanoma
Trial Shows Encorafenib and Binimetinib for Melanoma Patients
This trial evaluates the safety and efficacy of encorafenib and binimetinib in patients with resected stage IIB/IIC melanoma.
A clinical trial shows that a combination of encorafenib and binimetinib may improve recurrence-free survival for patients with specific mel…