Adaptive immune signatures and T cell infiltration characterize pathology in Alzheimer's, Parkinson's, and Lewy Body dementia
Adaptive Immune Signatures Linked to Alzheimer's and Parkinson's Disease
This mini review synthesizes evidence regarding adaptive immune remodeling and T cell responses in neurodegenerative dementias. The authors …
New research highlights how specific immune cell activity may play a role in the progression of Alzheimer's, Parkinson's, and Lewy body deme…
Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
Inflammatory markers linked to Alzheimer's and other dementia types
This systematic review and meta-analysis examined 41 eligible studies involving healthy controls and patients with various dementia subtypes…
A large review found that people with Alzheimer's and other dementias show higher inflammation than healthy people, though more research is …
Review of iRBD biomarker-positive participants shows higher rates of cognitive and autonomic symptoms compared to healthy controls
Sleep disorder signals hidden brain changes before official Parkinson's diagnosis
This observational review analyzes data from 197 iRBD participants with positive CSF neuronal alpha-synuclein seed amplification assay and 1…
People with this specific sleep disorder show clear signs of brain changes that happen before doctors officially diagnose Parkinson's diseas…
Review synthesizes genetic and environmental risk factors for dementia with Lewy bodies
Genetic and environmental factors linked to dementia with Lewy bodies
This narrative review examines genetic susceptibility and environmental factors, such as pesticides and air pollution, in the context of dem…
A review suggests genes and exposures like pollution may contribute to dementia with Lewy bodies, though details remain incomplete.
CSF α-synuclein SAA detects Lewy body dementia with 95% sensitivity in multicenter cohort
Researchers find new test spots Lewy body dementia
This prospective cohort study of 398 patients from memory clinics found that CSF α-synuclein seed amplification assay (SAA) had 95% sensitiv…
A new blood and spinal fluid test accurately identifies Lewy body dementia, even when Alzheimer’s is also present, helping clarify diagnosis…
FDA Approves DATSCAN (ioflupane I-123) for Striatal Dopamine Transporter Visualization in Suspected Parkinsonian Syndromes or Dementia with Lewy Bodies
FDA approves new brain imaging drug to help doctors diagnose Parkinson's and similar conditions
DATSCAN is approved as an adjunct diagnostic for striatal dopamine transporter visualization using SPECT brain imaging in adult patients wit…
FDA approves new brain imaging drug to help doctors diagnose Parkinson's and similar conditions.
Observational review of phenoconversion rates and biomarker alignment in Parkinson's disease genetic cohorts
Do your symptoms match the biology, or is the disease hiding in plain sight?
This observational cohort analysis reviews phenoconversion rates and biomarker alignment in Parkinson's Progression Markers Initiative parti…
In people at genetic risk for Parkinson's, symptoms and biological markers often don't align, with nearly one-third showing advanced brain c…
Research across Dementia
Related studies from across the Dementia family.
Comprehensive dementia care interventions improve caregiver self-efficacy in those with lower baseline scores
Comprehensive Care Programs May Improve Confidence for Dementia Caregivers
This secondary analysis of a randomized pragmatic clinical trial involved 2037 caregivers of community-dwelling persons living with dementia…
Caregivers of people with dementia can improve their self-efficacy and confidence through comprehensive care programs.
Non-pharmacological interventions for sleep disturbances in mild cognitive impairment and early dementia provide management guidance
Sleep Care Plan for Early Dementia: Best Evidence
This integrative review and guideline identifies 44 evidence items across 11 themes for managing sleep disturbances in patients with mild co…
A new review maps 44 best evidence items for managing sleep problems in mild cognitive impairment and early dementia.
Impact of Domain Specific Physical Activity on Risk of All Cause Dementia
High levels of physical activity linked to lower dementia risk
A massive meta-analysis of over 4 million participants reveals that specific types of physical activity significantly influence dementia ris…
Active lifestyles, especially during leisure time, are linked to a lower risk of developing Alzheimer's and other forms of dementia.
Increased Risk of Dementia Diagnosis Among Individuals Diagnosed With Bipolar Disorder
Bipolar disorder linked to triple dementia risk
A large-scale meta-analysis identifies a significant correlation between bipolar disorder and an elevated risk of dementia diagnosis.
People with bipolar disorder face a higher risk of dementia, a new analysis finds. The link is strong but the evidence has limits.
Dementia prevalence 24.3% in older adults with psychotic disorders, meta-analysis finds
Dementia found in 1 in 4 older adults with psychotic disorders
This meta-analysis of older adults with psychotic disorders reports a pooled dementia prevalence of 24.3% (95% CI: 20.5%-28.5%), with high h…
A new analysis finds dementia in 24.3% of older adults with psychotic disorders, highlighting the need for better care planning.
Animal-assisted interventions improve depression in dementia, but not other outcomes
Animal interactions may help ease depression in people with dementia
This overview of systematic reviews and meta-analyses found moderate evidence that animal-assisted interventions (AAIs) improve depression i…
Interacting with animals can significantly improve feelings of depression for people living with dementia, according to a review of recent r…
Prolonged FVEP-P2 latency is associated with Alzheimer's disease and other forms of dementia
Brain Signal Delays Linked to Alzheimer's and Dementia Types
This meta-analysis of 18 comparisons involving 1,778 participants found significantly prolonged FVEP-P2 latency in patients with Alzheimer's…
A large review found that specific brain signal delays are linked to Alzheimer's disease and other forms of cognitive decline.
Person-centered non-pharmacological interventions significantly reduce verbal agitation in patients with dementia
Personalized care helps reduce agitation in people with dementia
This meta-analysis of randomized controlled trials evaluates the impact of person-centered non-pharmacological interventions on agitation in…
Tailored, person-centered care can significantly lower verbal agitation in people living with dementia compared to standard methods.
SGLT2 inhibitors significantly reduce dementia risk in patients with type 2 diabetes
Diabetes drugs may lower dementia risk, study finds
This network meta-analysis involving 845,433 participants analyzed the impact of SGLT2 inhibitors on dementia outcomes in patients with type…
A large analysis of over 845,000 people with type 2 diabetes found that certain diabetes drugs, especially empagliflozin, were linked to a l…
Gabapentinoid use is associated with modestly higher odds of Alzheimer's disease and related dementias
Reviewing the Link Between Gabapentin Use and Risk of Developing Dementia
This meta-analysis of 325,245 individuals found that gabapentinoid use was associated with modestly higher odds of Alzheimer's disease and r…
A large review looked at how gabapentin and pregabalin affect brain health. Some findings suggest a possible link to dementia.
Diabetic retinopathy is associated with a significantly higher risk of all-cause dementia
Diabetic retinopathy is linked to a higher risk of dementia
This meta-analysis of observational studies involving 2,887,409 patients found that diabetic retinopathy is associated with an increased ris…
A large analysis shows people with diabetic retinopathy may face an increased risk of developing dementia, highlighting the need for closer …
Elevated neutrophil-to-lymphocyte ratio correlates with greater cerebral small vessel disease burden and white matter hyperintensities
High Neutrophil Levels Linked to Brain Small Vessel Damage
This systematic review and meta-analysis of 62,961 patients found that elevated neutrophil-to-lymphocyte ratio (NLR) is associated with the …
A large analysis finds that higher neutrophil-to-lymphocyte ratios are linked to more severe damage in the brain's small blood vessels.
Questions about dementia with Lewy bodies
Do people with iRBD biomarkers have more cognitive symptoms than healthy controls?
People with iRBD biomarkers show worse cognitive performance than healthy controls, with higher rates of mild cognitive impairment and neuropsychiatric symptoms.
Full answer →Can DATSCAN imaging help diagnose dementia with Lewy bodies?
Yes, DATSCAN imaging helps diagnose dementia with Lewy bodies by showing reduced dopamine transport in the brain, which supports the diagnosis when other symptoms are unclear.
Full answer →