Adaptive immune signatures and T cell infiltration characterize pathology in Alzheimer's, Parkinson's, and Lewy Body dementia
Adaptive Immune Signatures Linked to Alzheimer's and Parkinson's Disease
This mini review synthesizes evidence regarding adaptive immune remodeling and T cell responses in neurodegenerative dementias. The authors …
New research highlights how specific immune cell activity may play a role in the progression of Alzheimer's, Parkinson's, and Lewy body deme…
Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
Inflammatory markers linked to Alzheimer's and other dementia types
This systematic review and meta-analysis examined 41 eligible studies involving healthy controls and patients with various dementia subtypes…
A large review found that people with Alzheimer's and other dementias show higher inflammation than healthy people, though more research is …
Review of iRBD biomarker-positive participants shows higher rates of cognitive and autonomic symptoms compared to healthy controls
Sleep disorder signals hidden brain changes before official Parkinson's diagnosis
This observational review analyzes data from 197 iRBD participants with positive CSF neuronal alpha-synuclein seed amplification assay and 1…
People with this specific sleep disorder show clear signs of brain changes that happen before doctors officially diagnose Parkinson's diseas…
Review synthesizes genetic and environmental risk factors for dementia with Lewy bodies
Genetic and environmental factors linked to dementia with Lewy bodies
This narrative review examines genetic susceptibility and environmental factors, such as pesticides and air pollution, in the context of dem…
A review suggests genes and exposures like pollution may contribute to dementia with Lewy bodies, though details remain incomplete.
CSF α-synuclein SAA detects Lewy body dementia with 95% sensitivity in multicenter cohort
Researchers find new test spots Lewy body dementia
This prospective cohort study of 398 patients from memory clinics found that CSF α-synuclein seed amplification assay (SAA) had 95% sensitiv…
A new blood and spinal fluid test accurately identifies Lewy body dementia, even when Alzheimer’s is also present, helping clarify diagnosis…
FDA Approves DATSCAN (ioflupane I-123) for Striatal Dopamine Transporter Visualization in Suspected Parkinsonian Syndromes or Dementia with Lewy Bodies
FDA approves new brain imaging drug to help doctors diagnose Parkinson's and similar conditions
DATSCAN is approved as an adjunct diagnostic for striatal dopamine transporter visualization using SPECT brain imaging in adult patients wit…
FDA approves new brain imaging drug to help doctors diagnose Parkinson's and similar conditions.
Observational review of phenoconversion rates and biomarker alignment in Parkinson's disease genetic cohorts
Do your symptoms match the biology, or is the disease hiding in plain sight?
This observational cohort analysis reviews phenoconversion rates and biomarker alignment in Parkinson's Progression Markers Initiative parti…
In people at genetic risk for Parkinson's, symptoms and biological markers often don't align, with nearly one-third showing advanced brain c…
Research across Dementia
Related studies from across the Dementia family.
Higher GrimAge epigenetic age acceleration is significantly associated with higher dementia risk
GrimAge metric shows link to increased risk of dementia
This meta-analysis of 46,365 individuals with neurodegenerative diseases found that only the GrimAge metric showed a significant association…
One specific biological age clock, known as GrimAge, showed a link to higher dementia risk in a large study of over 46,000 people.
Social isolation and loneliness are significant determinants of cognitive decline and dementia risk in older adults
Social isolation and loneliness increase risk of dementia in older adults
This systematic review examines the impact of social isolation and loneliness on cognitive decline and dementia risk in older adults. The au…
Loneliness and social isolation are linked to faster cognitive decline and a higher risk of dementia in older adults.
Chronic pain is associated with poorer executive functioning and processing speed in dementia patients
Chronic pain is linked to poorer thinking in people with dementia
This systematic scoping review explores the relationship between chronic pain and cognitive performance in individuals with dementia. The re…
Living with chronic pain may make it harder for people with dementia to manage tasks and process information quickly.
HMB and vitamin D enriched protein supplements may support muscle and cognitive health in dementia
Nutrition Drink May Help Muscles In Dementia Patients
This narrative review examines the role of high protein oral nutritional supplements enriched with HMB and vitamin D for older adults at ris…
A high protein drink with HMB and vitamin D may support muscle health in older adults with dementia, but brain benefits remain unproven.
HMGB1 acts as a progression-associated inflammatory amplifier in Alzheimer's, Parkinson's, and ALS models
New research explores a protein linked to several brain diseases
This narrative review explores the role of HMGB1 in various neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS. The auth…
A specific protein called HMGB1 may act as a driver of inflammation in conditions like Alzheimer's and Parkinson's disease.
Mesenchymal stromal cells and MSC-derived extracellular vesicles may reprogram neuroimmune responses in neurodegenerative diseases
Stem cells and vesicles show potential for neurodegenerative diseases
This critical review examines the mechanisms and translational barriers of mesenchymal stromal cells (MSCs) and MSC-derived extracellular ve…
New research explores how stem cell products might protect the brain and repair blood-brain barriers in diseases like Parkinson's and Alzhei…
HRSN assessment tools lack sufficient psychometric testing and reliability data for geriatric populations
New Review Highlights Gaps in Alzheimer's and Dementia Care Tools
This systematic review of 7 studies evaluated the methodological rigor and psychometric properties of HRSN assessment tools in older adults.…
Current tools used to measure social needs for seniors with dementia lack enough testing to ensure they are accurate for older adults.
Scoping review protocol to map living arrangement and carer variables in dementia help-seeking research
Mapping How Living Arrangements Affect Help Seeking for Dementia
This is a scoping review protocol, not a completed study, that will map how living arrangement and supporter or carer related variables are …
New research plans to map how living situations and family support impact how people with memory problems seek a diagnosis for dementia.
Impact of Receptor Stimulating Antihypertensive Medications on Alzheimer Disease Risk in Elderly Patients
Certain blood pressure medications may link to lower dementia risk
Retrospective analysis suggests receptor-stimulating antihypertensives may correlate with lower ADRD incidence compared to receptor-inhibiti…
A large study of over 1.5 million seniors suggests specific blood pressure medications may be linked to lower rates of dementia and cognitiv…
Comprehensive dementia care interventions improve caregiver self-efficacy in those with lower baseline scores
Comprehensive Care Programs May Improve Confidence for Dementia Caregivers
This secondary analysis of a randomized pragmatic clinical trial involved 2037 caregivers of community-dwelling persons living with dementia…
Caregivers of people with dementia can improve their self-efficacy and confidence through comprehensive care programs.
Non-pharmacological interventions for sleep disturbances in mild cognitive impairment and early dementia provide management guidance
Sleep Care Plan for Early Dementia: Best Evidence
This integrative review and guideline identifies 44 evidence items across 11 themes for managing sleep disturbances in patients with mild co…
A new review maps 44 best evidence items for managing sleep problems in mild cognitive impairment and early dementia.
Impact of Domain Specific Physical Activity on Risk of All Cause Dementia
High levels of physical activity linked to lower dementia risk
A massive meta-analysis of over 4 million participants reveals that specific types of physical activity significantly influence dementia ris…
Active lifestyles, especially during leisure time, are linked to a lower risk of developing Alzheimer's and other forms of dementia.
Questions about dementia with Lewy bodies
Do people with iRBD biomarkers have more cognitive symptoms than healthy controls?
People with iRBD biomarkers show worse cognitive performance than healthy controls, with higher rates of mild cognitive impairment and neuropsychiatric symptoms.
Full answer →Can DATSCAN imaging help diagnose dementia with Lewy bodies?
Yes, DATSCAN imaging helps diagnose dementia with Lewy bodies by showing reduced dopamine transport in the brain, which supports the diagnosis when other symptoms are unclear.
Full answer →