Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
Inflammatory markers linked to Alzheimer's and other dementia types
This systematic review and meta-analysis examined 41 eligible studies involving healthy controls and patients with various dementia subtypes…
A large review found that people with Alzheimer's and other dementias show higher inflammation than healthy people, though more research is …
Review of iRBD biomarker-positive participants shows higher rates of cognitive and autonomic symptoms compared to healthy controls
Sleep disorder signals hidden brain changes before official Parkinson's diagnosis
This observational review analyzes data from 197 iRBD participants with positive CSF neuronal alpha-synuclein seed amplification assay and 1…
People with this specific sleep disorder show clear signs of brain changes that happen before doctors officially diagnose Parkinson's diseas…
Review synthesizes genetic and environmental risk factors for dementia with Lewy bodies
Genetic and environmental factors linked to dementia with Lewy bodies
This narrative review examines genetic susceptibility and environmental factors, such as pesticides and air pollution, in the context of dem…
A review suggests genes and exposures like pollution may contribute to dementia with Lewy bodies, though details remain incomplete.
CSF α-synuclein SAA detects Lewy body dementia with 95% sensitivity in multicenter cohort
Researchers find new test spots Lewy body dementia
This prospective cohort study of 398 patients from memory clinics found that CSF α-synuclein seed amplification assay (SAA) had 95% sensitiv…
A new blood and spinal fluid test accurately identifies Lewy body dementia, even when Alzheimer’s is also present, helping clarify diagnosis…
FDA Approves DATSCAN (ioflupane I-123) for Striatal Dopamine Transporter Visualization in Suspected Parkinsonian Syndromes or Dementia with Lewy Bodies
FDA approves new brain imaging drug to help doctors diagnose Parkinson's and similar conditions
DATSCAN is approved as an adjunct diagnostic for striatal dopamine transporter visualization using SPECT brain imaging in adult patients wit…
FDA approves new brain imaging drug to help doctors diagnose Parkinson's and similar conditions.
Observational review of phenoconversion rates and biomarker alignment in Parkinson's disease genetic cohorts
Do your symptoms match the biology, or is the disease hiding in plain sight?
This observational cohort analysis reviews phenoconversion rates and biomarker alignment in Parkinson's Progression Markers Initiative parti…
In people at genetic risk for Parkinson's, symptoms and biological markers often don't align, with nearly one-third showing advanced brain c…
Research across Dementia
Related studies from across the Dementia family.
Rapid advancements in imaging and blood-based biomarkers are transforming the diagnosis and management of ADRD
New guidelines help doctors tell delirium from dementia
This clinical guideline provides a narrative review on the evolving diagnostic and treatment landscape for Alzheimer's disease and related d…
Delirium is acute and fluctuating; dementia is chronic. New guidelines help doctors tell them apart.
Extended occupational therapy showed no significant improvement in behavioral symptoms for dementia patients
Extended occupational therapy shows no added benefit for dementia
This randomized controlled trial evaluated community-dwelling adults with mild-to-moderate dementia in France. Participants received occupat…
Adding four more months of occupational therapy did not improve behavioral symptoms in people with mild-to-moderate dementia, compared to st…
GLP-1 receptor agonists may reduce cognitive decline in type 2 diabetes patients with dementia
GLP-1 drugs may slow cognitive decline in type 2 diabetes
A systematic review of systematic reviews and meta-analyses found that GLP-1 receptor agonists are associated with reduced overall cognitive…
A review of reviews suggests GLP-1 drugs like Ozempic may help protect memory and thinking in people with type 2 diabetes.
SLE linked to 53% higher odds of cognitive impairment in meta-analysis of 7 million
Lupus linked to higher risk of cognitive decline
This meta-analysis of 7 observational studies involving over 7 million participants found that systemic lupus erythematosus (SLE) is signifi…
People with lupus may face 53% higher odds of cognitive impairment, a large analysis finds.
Dog-assisted therapy significantly improves behavioral symptoms in dementia patients compared to routine care in a systematic review
Dog-assisted therapy improves behavior in dementia patients
This systematic review and meta-analysis of 10 randomized controlled trials evaluated dog-assisted therapy for patients with dementia. The p…
A meta-analysis suggests dog-assisted therapy may reduce behavioral symptoms in dementia patients, though evidence remains weak due to study…
Higher EAT-Lancet diet adherence linked to lower risks of depression, anxiety, stroke, and dementia in observational cohorts
Eating healthy plant foods may lower risk of depression, anxiety, stroke, and dementia in older adults
This systematic review and meta-analysis examined associations between adherence to the EAT-Lancet diet and neuropsychiatric disorders acros…
A review of many studies found that following a plant-based diet like EAT-Lancet was linked to lower chances of depression, anxiety, stroke,…
Systematic review and meta-analysis of retinal biomarkers in frontotemporal dementia and Alzheimer disease
Retinal scans show thinner layers in frontotemporal dementia than Alzheimer disease
This systematic review and meta-analysis synthesized optical coherence tomography data on retinal biomarkers in frontotemporal dementia, Alz…
A new analysis of retinal scans found that people with frontotemporal dementia have thinner eye layers than those with Alzheimer disease or …
Depression linked to higher risk of progression from mild cognitive impairment to Alzheimer's disease and dementia in adults
Depression Linked to Higher Risk of Dementia Progression in Mild Cognitive Impairment
This systematic review and meta-analysis evaluated the association between depression and progression from mild cognitive impairment to Alzh…
A new analysis suggests depression may increase the risk of dementia progression in adults with mild cognitive impairment, though evidence c…
Meta-analysis suggests high BMI causally increases vascular-related dementia risk via blood pressure mediation
Higher body weight linked to increased risk of vascular dementia
This Mendelian randomization meta-analysis evaluates the causal link between high body mass index and vascular-related dementia. The analysi…
A large genetic study shows that a higher body mass index (BMI) raises the risk of vascular-related dementia. High blood pressure plays a ke…
Meta-analysis of Mendelian randomization suggests GLP-1 receptor agonism lowers vascular dementia risk
Genetic data suggests GLP-1 drugs may lower vascular dementia risk
This meta-analysis of Mendelian randomization studies evaluated the association between GLP-1 receptor agonism and dementia risk using genet…
New genetic evidence hints that GLP-1 receptor agonists might lower the risk of vascular dementia, but results for Alzheimer's disease remai…
Antipsychotic use persists in hospitalized dementia patients despite intervention
Antipsychotics Stay High Despite New Care Plans
This secondary analysis of an RCT examined antipsychotic use in 455 hospitalized older adults with dementia across 12 nursing homes. The int…
Older adults with dementia often leave the hospital on strong drugs that may not help them feel better at home.
Meta-analysis links acute kidney injury to increased stroke, delirium, and dementia risk
Kidney Injury Today Linked to Higher Stroke and Dementia Risk Tomorrow
This systematic review and meta-analysis synthesized data from 11,253,825 participants on associations between acute kidney injury and subse…
New research shows kidney injury dramatically increases later dementia risk even after recovery surprising many who thought kidneys and brai…
Questions about dementia with Lewy bodies
Do people with iRBD biomarkers have more cognitive symptoms than healthy controls?
People with iRBD biomarkers show worse cognitive performance than healthy controls, with higher rates of mild cognitive impairment and neuropsychiatric symptoms.
Full answer →Can DATSCAN imaging help diagnose dementia with Lewy bodies?
Yes, DATSCAN imaging helps diagnose dementia with Lewy bodies by showing reduced dopamine transport in the brain, which supports the diagnosis when other symptoms are unclear.
Full answer →