Adaptive immune signatures and T cell infiltration characterize pathology in Alzheimer's, Parkinson's, and Lewy Body dementia
Adaptive Immune Signatures Linked to Alzheimer's and Parkinson's Disease
This mini review synthesizes evidence regarding adaptive immune remodeling and T cell responses in neurodegenerative dementias. The authors …
New research highlights how specific immune cell activity may play a role in the progression of Alzheimer's, Parkinson's, and Lewy body deme…
Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
Inflammatory markers linked to Alzheimer's and other dementia types
This systematic review and meta-analysis examined 41 eligible studies involving healthy controls and patients with various dementia subtypes…
A large review found that people with Alzheimer's and other dementias show higher inflammation than healthy people, though more research is …
Review of iRBD biomarker-positive participants shows higher rates of cognitive and autonomic symptoms compared to healthy controls
Sleep disorder signals hidden brain changes before official Parkinson's diagnosis
This observational review analyzes data from 197 iRBD participants with positive CSF neuronal alpha-synuclein seed amplification assay and 1…
People with this specific sleep disorder show clear signs of brain changes that happen before doctors officially diagnose Parkinson's diseas…
Review synthesizes genetic and environmental risk factors for dementia with Lewy bodies
Genetic and environmental factors linked to dementia with Lewy bodies
This narrative review examines genetic susceptibility and environmental factors, such as pesticides and air pollution, in the context of dem…
A review suggests genes and exposures like pollution may contribute to dementia with Lewy bodies, though details remain incomplete.
CSF α-synuclein SAA detects Lewy body dementia with 95% sensitivity in multicenter cohort
Researchers find new test spots Lewy body dementia
This prospective cohort study of 398 patients from memory clinics found that CSF α-synuclein seed amplification assay (SAA) had 95% sensitiv…
A new blood and spinal fluid test accurately identifies Lewy body dementia, even when Alzheimer’s is also present, helping clarify diagnosis…
FDA Approves DATSCAN (ioflupane I-123) for Striatal Dopamine Transporter Visualization in Suspected Parkinsonian Syndromes or Dementia with Lewy Bodies
FDA approves new brain imaging drug to help doctors diagnose Parkinson's and similar conditions
DATSCAN is approved as an adjunct diagnostic for striatal dopamine transporter visualization using SPECT brain imaging in adult patients wit…
FDA approves new brain imaging drug to help doctors diagnose Parkinson's and similar conditions.
Observational review of phenoconversion rates and biomarker alignment in Parkinson's disease genetic cohorts
Do your symptoms match the biology, or is the disease hiding in plain sight?
This observational cohort analysis reviews phenoconversion rates and biomarker alignment in Parkinson's Progression Markers Initiative parti…
In people at genetic risk for Parkinson's, symptoms and biological markers often don't align, with nearly one-third showing advanced brain c…
Research across Dementia
Related studies from across the Dementia family.
Pain assessment guidelines for cognitively impaired older adults lack practical detail
Pain guidelines for dementia patients lack practical advice
This scoping review mapped pain assessment guidelines for hospitalized older adults with cognitive impairment. No Australian guidelines were…
A review finds most pain assessment guidelines for older adults with dementia offer little practical help for hospital staff.
Network meta-analysis protocol aims to rank structured exercise interventions for fall prevention in dementia
Exercise Programs May Help Prevent Falls in Seniors with Dementia
This is a protocol for a systematic review and network meta-analysis regarding structured exercise interventions for older adults with mild …
A planned review aims to determine which types of structured exercise best help older adults with memory loss stay safe and avoid falling.
Multidomain lifestyle interventions provide small but statistically significant benefits for global cognition scores
Multidomain lifestyle changes may help slow signs of dementia
This meta-analysis of randomized controlled trials involving 23209 participants found that multidomain lifestyle interventions (three or mor…
Combining multiple lifestyle habits like diet and exercise can lead to small but steady improvements in brain health for those at risk of de…
TBP expansion in SCA17 can cause dementia-like symptoms and requires etiological reconsideration
New Diagnosis for Dementia Patients with Spinocerebellar Ataxia Type 17
This case report and focused literature review describes a patient with SCA17 presenting as dementia, highlighting the need for genetic test…
A new look at dementia cases may reveal an underlying genetic condition called spinocerebellar ataxia type 17.
Diabetes mellitus acts as a context-dependent modifier of risk and phenotype in neurological disorders
Diabetes May Influence Risk and Progress of Neurological Disorders
This narrative review synthesizes evidence regarding the role of diabetes mellitus (DM) as a disease modifier across various neurological co…
New research suggests that diabetes can change how certain neurological conditions progress, potentially opening doors for new treatment opt…
Ligustilide shows neuroprotective effects across multiple CNS disorders in preclinical models
Ligustilide Shows Potential for Treating Various Brain Disorders
This systematic review of 55 original studies evaluates the neuroprotective potential of ligustilide (LIG) in various neurological condition…
Early research on the compound ligustilide shows potential to protect brain cells from damage caused by stroke, dementia, and other neurolog…
The osteoimmune-brain axis links systemic inflammation and bone hormones to neurodegenerative pathology
Immune system may link bone health and brain disease
This systematic review examines the role of the osteoimmune-brain axis, where the immune system mediates skeletal and cerebral pathology thr…
A new look at the body's immune system suggests a link between bone health and conditions like Alzheimer's and dementia.
Rapid advancements in imaging and blood-based biomarkers are transforming the diagnosis and management of ADRD
New guidelines help doctors tell delirium from dementia
This clinical guideline provides a narrative review on the evolving diagnostic and treatment landscape for Alzheimer's disease and related d…
Delirium is acute and fluctuating; dementia is chronic. New guidelines help doctors tell them apart.
Extended occupational therapy showed no significant improvement in behavioral symptoms for dementia patients
Extended occupational therapy shows no added benefit for dementia
This randomized controlled trial evaluated community-dwelling adults with mild-to-moderate dementia in France. Participants received occupat…
Adding four more months of occupational therapy did not improve behavioral symptoms in people with mild-to-moderate dementia, compared to st…
GLP-1 receptor agonists may reduce cognitive decline in type 2 diabetes patients with dementia
GLP-1 drugs may slow cognitive decline in type 2 diabetes
A systematic review of systematic reviews and meta-analyses found that GLP-1 receptor agonists are associated with reduced overall cognitive…
A review of reviews suggests GLP-1 drugs like Ozempic may help protect memory and thinking in people with type 2 diabetes.
SLE linked to 53% higher odds of cognitive impairment in meta-analysis of 7 million
Lupus linked to higher risk of cognitive decline
This meta-analysis of 7 observational studies involving over 7 million participants found that systemic lupus erythematosus (SLE) is signifi…
People with lupus may face 53% higher odds of cognitive impairment, a large analysis finds.
Dog-assisted therapy significantly improves behavioral symptoms in dementia patients compared to routine care in a systematic review
Dog-assisted therapy improves behavior in dementia patients
This systematic review and meta-analysis of 10 randomized controlled trials evaluated dog-assisted therapy for patients with dementia. The p…
A meta-analysis suggests dog-assisted therapy may reduce behavioral symptoms in dementia patients, though evidence remains weak due to study…
Questions about dementia with Lewy bodies
Do people with iRBD biomarkers have more cognitive symptoms than healthy controls?
People with iRBD biomarkers show worse cognitive performance than healthy controls, with higher rates of mild cognitive impairment and neuropsychiatric symptoms.
Full answer →Can DATSCAN imaging help diagnose dementia with Lewy bodies?
Yes, DATSCAN imaging helps diagnose dementia with Lewy bodies by showing reduced dopamine transport in the brain, which supports the diagnosis when other symptoms are unclear.
Full answer →