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Home › Conditions › dental plaque

Dental plaque

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for dental plaque

36 trials tracked for dental plaque: 15 in phase 3 or 4 and 1 with published results. The most-cited published study has 14 citations.

36Trials tracked
15Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 4 Phase 3 11 Phase 2 4 Other / NA 17
  1. Phase 4 Six Month Plaque and Gingivitis Study Using Colgate Total Toothpaste Completed · 14 cited
  2. Phase 4 The Clinical Investigation of Toothpaste as Compared to Toothpaste and Mouthwash in Reducing Plaque and Gingivitis: A Six-week Clinical Study in the US Completed
  3. Phase 4 Clinical Study Comparing Dental Plaque and Gingivitis Reduction After Using One of Three Oral Hygiene Multi-component Regimens (Using of a Manual Toothbrush, a Toothpaste and a Mouthwash) Completed
  4. Phase 4 Cetylpyridium Chloride (CPC) Based Chewing Gum and Gingivitis Completed
  5. Phase 3 Evaluate Dental Plaque Benefit of a Preventive Treatment Gel Completed
  6. Phase 3 Clinical Research Study Efficacy of a Prototype Oral Rinse Completed
Show 30 more trials
  1. Phase 3 Train New Examiners Via Modified Gingival Margin Plaque Completed
  2. Phase 3 Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse Completed
  3. Phase 3 Effect on Bacterial Glycolytic Acid Formation on Plaque Completed
  4. Phase 3 Development of Clinical Method to Triclosan Retention in Plaque Following Brushing Completed
  5. Phase 3 The Clinical Efficacy of Three Oral Hygiene Regimens Using a Manual Toothbrush, Toothpaste and a Mouthwash in Controlling Dental Plaque and Gingivitis Completed
  6. Phase 3 Investigation of Dental Plaque and Gingival Index Completed
  7. Phase 3 Clinical Study to Compare Dental Plaque Control Completed
  8. Phase 3 Clinical Study to Evaluate the Treatment of Gingivitis of Two Toothpastes Completed
  9. Phase 3 Compare the Clinical Efficacy of Prototype Toothpastes Completed
  10. Phase 2 Dental Plaque Removal Ability of Prototype Power Toothbrush Versus a Manual Toothbrush in Healthy Participants Completed
  11. Phase 2 Clinical Efficacy Evaluation of Three Dentifrices Completed
  12. Phase 2 Evaluation of Oral Plaque Removal Utilizing an Adjunct Enzyme Pre-rinse Completed
  13. Phase 2 Evaluating Commercial Anti-Plaque Products and Oral Rinse Completed
  14. N/A Ability of Four Toothpastes to Remove Plaque Completed
  15. N/A Efficacy of Three Experimental Toothpastes to Remove Plaque Completed
  16. N/A A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation Completed
  17. N/A A Study to Investigate the Antimicrobial Activity of 2 Test Toothpastes Completed
  18. N/A Efficacy of Manual Toothbrushes in Removing Dental Plaque Completed
  19. N/A Effectiveness of Customized Handle Toothbrush Completed
  20. N/A Efficacy of Plaque Removal of a Novel Brushing Device Completed
  21. N/A Oral Health Literacy Tailored Communication Completed
  22. N/A Evaluation of Toothbrush Bristles in Plaque Reduction Completed
  23. N/A A Clinical Study Investigating the Effect of an Experimental Toothpaste Containing Stannous Fluoride in Improving Gingival Health Completed
  24. N/A Efficacy of a Commercial Dentifrice Containing Ilex Rotunda Thunb Extract for Dental Plaque and Gingivitis Completed
  25. N/A Evaluating the Effect of Tooth Cleaning Devices on Oral Health Completed
  26. N/A A Comparative Study of Electric Toothbrushes for the Efficacy Plaque Removal and the Effect on Plaque Accumulation and Gingivitis. Completed
  27. N/A BEhavioral EConomics for Oral Health iNnovation Trial Completed
  28. N/A Dental Office Prevention Strategies for Children Completed
  29. N/A A Four-Week Study to Measure the Effectiveness of an Experimental Mouthwash Used After Teeth Cleaning Completed
  30. N/A A Clinical Study Investigating the Effects of a Dentifrice Containing 67% Sodium Bicarbonate When Used Twice Daily for 12 Weeks on Gingivitis Treatment and Plaque Removal Completed

Showing the 36 most-cited and recently-updated of 36 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Dental plaque: what the trials found

Several studies evaluated the efficacy of various agents in managing dental plaque. Triclosan combined with fluoride was shown to significantly impact both dental plaque scores and gingivitis scores across multiple trials [5, 6]. Specifically, one study reported significant reductions in plaque scores (1.84; 1.86; 2.37, p<0.001) and gingivitis scores (1.17; 1.18; 1.85, p<0.001) 6, while another showed significant results for both plaque and gingivitis scores in a triclosan/fluoride formulation 5.

Fluoride-based interventions demonstrated consistent effects on dental plaque indices across multiple trials. Significant reductions were observed in plaque index values in studies utilizing fluoride alone [10, 14, 17, 21], while sodium monofluorophosphate was also shown to impact gingival margin plaque index 15. Additionally, a study using iodine showed significant improvements in the plaque index (2.47; 2.11, p=0.05) and gingival indices 13.

Specific formulations like Colgate Cavity Protection toothpaste were shown to significantly reduce dental plaque scores 3. Research into the chemical environment of plaque found that triclosan and fluoride maintained a specific pH after sucrose challenge (4.88; 5.04; 4.98, p=0.05) 9.

A combination of triclosan/fluoride toothpaste and a cetylpyridinium chloride mouthwash was associated with significant results for both dental plaque scores (2.42; 2.59; 3.38, p<0.001) and gingivitis scores (1.03; 1.21; 1.46, p<0.001) 8.

Recent results — preliminary, needs further review

  • Stannous Fluoride toothpaste significantly reduced the number of bleeding sites (NBS) at both week 6 and week 12 compared to a negative control 1.
  • A test toothpaste showed no significant difference in adjusted mean bleeding index or number of bleeding sites at week 4, but did show a significant reduction in modified gingival index (MGI) 2.

For the clinician treating this condition

  • Triclosan combined with fluoride is an established intervention for reducing both dental plaque scores and associated gingivitis.
  • Fluoride-based treatments, including specific formulations like sodium monofluorophosphate, are established methods for lowering plaque indices.
  • Stannous Fluoride toothpaste has shown significant efficacy in reducing bleeding sites at 6 and 12 weeks compared to control groups.

AI synthesis of 9 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Biodegradable oral hygiene tools show no clear plaque reduction versus plastic toothbrushes
Pediatrics Meta-analysis
Biodegradable oral hygiene tools show no clear plaque reduction versus plastic toothbrushes Natural toothbrushes work as well as plastic for plaque
This meta-analysis of 408 children and adults found no clear difference in plaque index between biodegradable/natural oral hygiene tools and…
Bamboo toothbrushes and miswak sticks may remove plaque just as well as plastic ones, but the evidence is weak.
Frontiers Jun 25, 2026
Systematic review suggests interdental brushes may reduce plaque and inflammation in orthodontic patients compared with other methods
Pediatrics Meta-analysis
Systematic review suggests interdental brushes may reduce plaque and inflammation in orthodontic patients compared with other methods Interdental brushes might help reduce plaque and gum inflammation for patients with braces
This systematic review evaluated interdental brushes (IDB) versus toothbrushing alone, floss, orthodontic toothbrushes, monotufted brushes, …
A review of studies found that using interdental brushes with braces may lower plaque and gum swelling better than just flossing. However, t…
Frontiers May 7, 2026
Video and plaque disclosing tablets improved oral hygiene indices in adult orthodontic patients compared to verbal instructions alone
Primary Care & Family Medicine RCT
Video and plaque disclosing tablets improved oral hygiene indices in adult orthodontic patients compared to verbal instructions alone Verbal instructions may be enough for orthodontic patients to improve oral hygiene
This open label randomised controlled trial enrolled 96 participants randomised to receive video, plaque disclosing tablets, or verbal instr…
A trial of 96 adult orthodontic patients found that simple verbal instructions improved oral hygiene just as well as video or plaque tablets…
May 1, 2026