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Diabetic Nephropathy

Part of Diabetes

7 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Diabetic Nephropathy

15 trials tracked for Diabetic Nephropathy: 9 in phase 3 or 4 and 4 with published results. The most-cited published study has 129 citations.

15Trials tracked
9Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 4 Phase 3 5 Phase 2 6
  1. Phase 4 Nephropathy In Type 2 Diabetes and Cardio-renal Events Completed · 129 cited
  2. Phase 3 Efficacy and Safety of Canagliflozin (TA-7284) in Patients With Diabetic Nephropathy Completed · 27 cited
  3. Phase 3 Effect of Sulodexide in Early Diabetic Nephropathy Completed · 6 cited
  4. Phase 3 Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants With Diabetic Nephropathy Completed · 4 cited
  5. Phase 4 Lipo-prostaglandin E1 Improves Renal Hypoxia Evaluated by BOLD-MRI in Patients With Diabetic Nephropathy Completed
  6. Phase 4 Immunosuppression Impact on the Metabolic Control of Kidney Transplant With Pre-Existing Type 2 Diabetes (DM) Completed
Show 9 more trials
  1. Phase 4 Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes Completed
  2. Phase 3 ORIENT: Olmesartan Reducing Incidence of End Stage Renal Disease in Diabetic Nephropathy Trial Completed
  3. Phase 3 Renoprotection in Early Diabetic Nephropathy in Pima Indians Completed
  4. Phase 2 The Effect of Paricalcitol Capsules on Reducing Albuminuria in Patients With Type 2 Diabetic Nephropathy Being Treated With Renin-angiotensin System Inhibitors Completed
  5. Phase 2 Study of LY3016859 in Participants With Diabetic Nephropathy Completed
  6. Phase 2 A Phase 2 Multi-Center Study To Evaluate The Efficacy And Safety Of A Chemokine CCR2/5 Receptor Antagonist In Adults With Type 2 Diabetes And Overt Nephropathy Completed
  7. Phase 2 Safety, Tolerability and Efficacy of Nidufexor in Patients With Diabetic Nephropathy Completed
  8. Phase 2 Acthar for Treatment of Proteinuria in Diabetic Nephropathy Patients Completed
  9. Phase 2 N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy Completed

Showing the 15 most-cited and recently-updated of 15 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Diabetes

Related studies from across the Diabetes family.

Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy
Neurology Sys. Review
Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy New research explores how inflammation drives nerve damage in diabetes
This narrative review explores the pathophysiology of diabetic peripheral neuropathy, focusing on how hyperglycemia, lipotoxicity, and intes…
Chronic high blood sugar causes more than just high glucose; it triggers a cycle of inflammation and immune stress that damages nerves.
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems
Diabetes & Endocrinology Sys. Review
Chronic hyperglycemia causes multi-level nerve damage across the peripheral, autonomic, and central nervous systems Understanding how high blood sugar damages the entire nervous system in diabetes
This narrative review synthesizes how chronic hyperglycemia impacts the entire neuroaxis in patients with diabetes. It details metabolic and…
High blood sugar can damage nerves throughout the whole body. This affects your senses, movement, and internal organs.
Intravitreal ziv-aflibercept reduces central macular thickness and improves visual acuity in DME and RVO
Ophthalmology Meta-analysis
Intravitreal ziv-aflibercept reduces central macular thickness and improves visual acuity in DME and RVO Trial shows ziv-aflibercept improves vision in macular edema cases
This systematic review and meta-analysis of 5 RCTs and 8 observational studies found that intravitreal ziv-aflibercept significantly reduced…
A new eye treatment called ziv-aflibercept may help reduce swelling and improve vision for patients with specific types of macular edema.
Local antibiotic delivery systems increase healing rates in diabetic foot osteomyelitis compared with control groups in this meta-analysis
Infectious Disease Meta-analysis
Local antibiotic delivery systems increase healing rates in diabetic foot osteomyelitis compared with control groups in this meta-analysis Local Antibiotics May Boost Healing in Diabetic Foot Infections
This systematic review and meta-analysis evaluated local antibiotic delivery systems versus control groups for patients with diabetic foot o…
A new analysis suggests local antibiotic delivery may improve healing for diabetic foot bone infections, but more research is needed.
Antibiotic cement achieves 85.2% healing rate in diabetic foot osteomyelitis meta-analysis
Diabetes & Endocrinology Meta-analysis
Antibiotic cement achieves 85.2% healing rate in diabetic foot osteomyelitis meta-analysis Antibiotic cement may help heal diabetic foot infections without major surgery
A systematic review and meta-analysis of 82 patients with diabetic foot osteomyelitis found a weighted healing rate of 85.2% with antibiotic…
A meta-analysis suggests antibiotic-impregnated cement can heal diabetic foot osteomyelitis in most patients, though some still need surgery…
SGLT2 inhibitor use associated with increased diabetic ketoacidosis risk, especially with elevated HbA1c
Diabetes & Endocrinology Meta-analysis
SGLT2 inhibitor use associated with increased diabetic ketoacidosis risk, especially with elevated HbA1c New review shows SGLT2 drugs raise DKA risk when blood sugar is high
This meta-analysis of observational and randomized trials found SGLT2 inhibitor use is associated with an increased risk of diabetic ketoaci…
A big review of many studies found that medicines for diabetes called SGLT2 inhibitors can increase the chance of a serious condition called…
Perioperative anti-VEGF injections improve vision and reduce bleeding in proliferative diabetic retinopathy
Ophthalmology Meta-analysis
Perioperative anti-VEGF injections improve vision and reduce bleeding in proliferative diabetic retinopathy Anti-VEGF injections before eye surgery improve vision and reduce bleeding in diabetic retinopathy
This network meta-analysis evaluated the timing of perioperative anti-VEGF injections for proliferative diabetic retinopathy. Results indica…
A network meta-analysis of 2,646 eyes found that perioperative anti-VEGF injections improved vision and reduced bleeding in patients with pr…
Exosomes show promise as biomarkers and therapeutic vectors in diabetic complications
Drug Pipeline Sys. Review
Exosomes show promise as biomarkers and therapeutic vectors in diabetic complications Review suggests exosomes may help target multiple diabetes complications
This narrative review explores the role of exosomes in diabetic kidney disease, retinopathy, and peripheral neuropathy. It highlights their …
A narrative review suggests exosomes might inform strategies to target multiple diabetes complications together, though clinical standardiza…
Scoping review maps burden of diabetic emergencies in African healthcare settings
Emergency Medicine Sys. Review
Scoping review maps burden of diabetic emergencies in African healthcare settings Diabetic emergencies in Africa show wide variation in rates and outcomes
This scoping review synthesizes data from 25 studies regarding diabetic emergencies in Africa. The authors report wide variation in reported…
A review of 25 studies finds diabetic emergencies in Africa vary widely, with high death rates and long hospital stays.
Review of 16 cases shows 25% mortality for pulmonary mucormycosis in DKA patients treated with amphotericin B
Rheumatology Meta-analysis
Review of 16 cases shows 25% mortality for pulmonary mucormycosis in DKA patients treated with amphotericin B Treatment for rare lung infection kills one in four patients with diabetic ketoacidosis
This case report and literature review synthesizes data from 16 patients with diabetic ketoacidosis complicated by invasive pulmonary mucorm…
A review of 16 patients found that one in four died from this rare lung infection. Early diagnosis and surgery are key.
Narrative review suggests suprachoroidal injections may improve vision and reduce edema in diabetic macular edema
Rheumatology Sys. Review
Narrative review suggests suprachoroidal injections may improve vision and reduce edema in diabetic macular edema New eye injection method reduces shots and protects vision for diabetics
This narrative review examines suprachoroidal space injections versus conventional intravitreal therapies for diabetic macular edema. The au…
A new injection technique for diabetic eye disease could spare patients from frequent shots and lower the risk of cataracts while improving …
Review of immune checkpoint inhibitor-associated diabetes mellitus in two patients
Allergy & Immunology Sys. Review
Review of immune checkpoint inhibitor-associated diabetes mellitus in two patients Diabetes Danger Lingers Months After Cancer Treatment Ends
This narrative review and case report describes two patients with immune checkpoint inhibitor-associated diabetes mellitus. The authors synt…
• Some patients develop dangerous diabetes long after stopping immunotherapy • Helps cancer survivors using newer immune-boosting drugs • St…