Completion thyroidectomy follows total thyroidectomy for similar operative safety in differentiated thyroid cancer
Less surgery may be safer for thyroid cancer patients
This meta-analysis of 43,362 patients evaluated the surgical safety of completion thyroidectomy (CT) compared to upfront total thyroidectomy…
For some thyroid cancers, a less extensive surgery may be safer with fewer complications.
TSH suppression therapy promotes tumor progression via G-protein signaling pathways in differentiated thyroid cancer
TSH Suppression Therapy Framework for Differentiated Thyroid Cancer
This systematic review synthesizes the biological mechanisms of TSH-mediated tumor progression and proposes a clinical decision-making frame…
New research outlines how TSH levels impact thyroid cancer growth and offers a new decision-making framework for personalized patient care.
I-SPECT/CT shows high patient-level specificity of 0.95 for detecting residual disease in DTC
Imaging technology shows promise for detecting thyroid cancer recurrence
This meta-analysis evaluates the diagnostic efficacy of I-SPECT/CT for identifying residual or recurrent disease in patients with differenti…
A new imaging method called I-SPECT/CT helps doctors find leftover or returning thyroid cancer cells with high accuracy after treatment.
Hemithyroidectomy is associated with a 3% higher risk difference in cancer recurrence rate
Hemithyroidectomy linked to higher thyroid cancer recurrence
This meta-analysis of 98,604 patients with differentiated thyroid carcinoma found that hemithyroidectomy (HT) was associated with a 3% highe…
A large meta-analysis found that hemithyroidectomy for differentiated thyroid cancer has a higher recurrence rate than total thyroidectomy, …
Symptom Network Changes in Differentiated Thyroid Cancer Patients Undergoing Radioactive Iodine Therapy
Radioactive iodine therapy changes how symptoms connect in patients
This prospective cohort study of 520 patients with differentiated thyroid cancer found that radioactive iodine therapy significantly reorgan…
New research shows that radioactive iodine therapy reshapes how physical and psychological symptoms interact in people with thyroid cancer.
Research across Cancer
Related studies from across the Cancer family.
Laryngeal obstruction as initial sign of MEN2B in two pediatric cases with RET mutations
Rare genetic disorder first shows as breathing trouble in children
This case report describes 2 pediatric patients with MEN2B presenting with laryngeal obstruction and progressive respiratory compromise as i…
Two children with a rare genetic condition first showed breathing trouble from nerve growths in the airway, not the usual symptoms.
WBRT shows no significant survival benefit in thyroid cancer brain metastases meta-analysis
Whole-brain radiation shows no clear survival benefit for thyroid cancer brain metastases
A systematic review and individual patient data meta-analysis of 247 patients with thyroid cancer brain metastases found whole-brain radiati…
Whole-brain radiation therapy showed no clear survival benefit for patients with thyroid cancer that spread to their brain.
Nivolumab monotherapy yielded 12-month progression-free survival in metastatic anaplastic thyroid cancer
Off-label immunotherapy may help some patients with metastatic anaplastic thyroid cancer
This case report describes a 76-year-old female with metastatic anaplastic thyroid cancer treated with off-label nivolumab monotherapy. The …
A single case report suggests off-label nivolumab helped a 76-year-old woman live longer with metastatic anaplastic thyroid cancer.
Meta-analysis finds germline LTS and somatic TERT variants are mutually exclusive in thyroid cancer and melanoma
Two different cancer drivers do not appear together in these tumors
This meta-analysis of retrospective observational cohorts examined germline long-telomere syndrome variants and somatic TERT promoter altera…
A large review of nearly 2,000 adults with thyroid cancer or melanoma found that two specific genetic changes never occur in the same tumor.
Case report details multimodal treatment for aggressive thyroid carcinoma
First new treatment combination in six months stabilizes advanced thyroid cancer
A 61-year-old man with papillary thyroid carcinoma achieved disease stabilization after thyroidectomy, radiotherapy, and targeted therapy. T…
A 61-year-old man with advanced thyroid cancer saw his disease stop growing after a specific mix of treatments within six months of his diag…
Trastuzumab emtansine and trastuzumab deruxtecan use in three patients with ERBB2-amplified rare tumors
Rare tumors respond to targeted antibody drug treatments
This retrospective case series evaluated three patients with ERBB2-amplified rare tumors, including periampullary, salivary duct, and poorly…
Three patients with rare, aggressive cancers saw significant tumor shrinkage after receiving targeted antibody drug therapies.
Central lymph node ratio threshold predicts lateral lymph node metastasis in pediatric differentiated thyroid carcinoma
One Number Might Predict Thyroid Cancer Spread in Children
This retrospective cohort study evaluated pediatric patients with differentiated thyroid carcinoma aged ≤14 years.
A simple number helps doctors predict if thyroid cancer will spread to side neck nodes in children under 14 years old.
TIRADS and Bethesda systems predict thyroid malignancy in 70 patients at Baghdad Teaching Hospital
Family history and neck swelling signal higher risk of thyroid cancer
This prospective cross-sectional study evaluated 70 patients with thyroid complaints at Baghdad Teaching Hospital.
A new look at thyroid nodules shows that family history and neck swelling are key signs of cancer, helping doctors catch it sooner.
Case series describes four clear cell variant papillary thyroid carcinoma cases with NCOA4-RET fusions
Rare Thyroid Cancer Has Unique Genetic Signature
This case series with literature review describes four pathologically confirmed cases of clear cell variant of papillary thyroid carcinoma d…
A rare thyroid cancer type may have a specific genetic cause that doctors can now look for.
Machine learning models predict survival in lymph-node-positive medullary thyroid carcinoma
A Machine Learning Tool Now Predicts Survival for One Tricky Thyroid Cancer
This cohort study evaluated machine learning models for predicting survival in patients with lymph-node-positive medullary thyroid carcinoma…
A new AI tool predicts survival for aggressive medullary thyroid cancer that has spread to lymph nodes, revealing that skipping surgery is t…
Autopsy study finds 55% thyroid nodular disease prevalence in Mexico City hospital patients
Autopsy study finds high thyroid nodule rates in Mexico City, no link to salt iodination
A retrospective cohort study of 487 autopsies from a third-level hospital in Mexico City found a thyroid nodular disease prevalence of 55% a…
Autopsies in Mexico City reveal thyroid nodules are very common, yet changing salt iodination rules did not increase their rates.
Encorafenib plus binimetinib maintains quality of life in BRAF V600E-mutated thyroid cancer
Can new drugs help advanced thyroid cancer patients keep their daily life stable?
An uncontrolled phase 2 trial of 22 patients with BRAF V600E-mutated thyroid cancer found encorafenib plus binimetinib was associated with g…
A new drug combination helped advanced thyroid cancer patients maintain daily life stability without worsening their quality of life during …
Questions about differentiated thyroid cancer
Is there a higher recurrence rate with hemithyroidectomy for differentiated thyroid cancer?
Yes, hemithyroidectomy is associated with a higher recurrence rate for differentiated thyroid cancer, with a 3% absolute risk increase compared to total thyroidectomy.
Full answer →What are the side effects of radioactive iodine therapy for differentiated thyroid cancer?
Radioactive iodine therapy for differentiated thyroid cancer commonly causes throat/mouth symptoms, psychological distress, and fatigue, with rare serious side effects like bone marrow suppression.
Full answer →Does a hemithyroidectomy increase the risk of recurrence in differentiated thyroid cancer?
Hemithyroidectomy is linked to a slightly higher recurrence risk (about 3% absolute increase) compared to total thyroidectomy, but for low-risk patients the difference is small and may be acceptable.
Full answer →Does TSH suppression therapy cause tumor progression in differentiated thyroid cancer?
TSH suppression therapy is used to control and slow the progression of differentiated thyroid cancer by preventing the hormone from stimulating tumor growth.
Full answer →