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Home › Conditions › Dysthymia

Dysthymia

0 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Dysthymia

9 trials tracked for Dysthymia: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 24 citations.

9Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 4 Phase 2 3 Other / NA 2
  1. Phase 4 A Study of L-DOPA for Depression and Slowing in Older Adults Completed · 24 cited
  2. Phase 4 Desvenlafaxine vs. Placebo Treatment of Chronic Depression Completed · 7 cited
  3. Phase 4 Dichotic Listening as a Predictor of Medication Response in Depression Completed
  4. Phase 4 Project to Improve Symptoms and Mood in People With Spinal Cord Injury Completed
  5. Phase 2 Safety and Efficacy Study of Citalopram and Lithium for the Treatment of Depressive Mood Disorder Symptoms Completed
  6. Phase 2 Dichotic Listening as a Predictor of Medication Response in Depression Completed
Show 3 more trials
  1. Phase 2 Pramipexole to Target "Anhedonic Depression" Completed
  2. N/A Treating Depression Among Low-Income Patients With Cancer Completed
  3. N/A Cognitive Behavioral Therapy (REBT/CBT) Evaluation for Dysthymia in the Practice of Clinical Social Work at Primary Care Completed

Showing the 9 most-cited and recently-updated of 9 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Dysthymia: what the trials found

Pharmacological management of dysthymia includes several established options. Desvenlafaxine demonstrated a significant response rate in clinical trials 2. Venlafaxine XR showed statistically significant improvements in both the Hamilton Depression Rating Scale-17 (p=<.025) and the Hamilton Depression Rating Scale-Maier Subscale (p=<.025) 4.

Other established pharmacological interventions for dysthymia include Levodopa 1 and escitalopram 3.

Recent results — preliminary, needs further review

  • Pramipexole Pill showed a reduction in Montgomery Åsberg Depression Rating Scale (MADRS) scores from 26.33 to 15.67, alongside an increase in Dimensional Anhedonia Rating Scale (DARS) scores from 15.75 to 33.08 5.

For the clinician treating this condition

  • Venlafaxine XR is supported by evidence showing significant improvements across multiple depression rating scales 4.
  • Desvenlafaxine has demonstrated a statistically significant response rate in patients with dysthymia 2.
  • Levodopa and escitalopram are established pharmacological options for this condition [1, 3].

AI synthesis of 5 cited trials, updated Jul 31, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
No published articles yet for this condition. Check back soon.