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Home › Conditions › Eye Diseases

Eye Diseases

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Eye Diseases

16 trials tracked for Eye Diseases: 5 in phase 3 or 4 and 2 with published results. The most-cited published study has 4 citations.

16Trials tracked
5Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 5 Phase 2 5 Phase 1 2 Other / NA 4
  1. Phase 3 Study to Collect Safety and ECG Data on Brolucizumab 6 mg Intravitreal Treatment in Patients With Wet AMD Completed · 4 cited
  2. Phase 3 FLuorometholone as Adjunctive MEdical Therapy for TT Surgery (FLAME) Trial Completed · 2 cited
  3. Phase 3 Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of Presbyopia Completed
  4. Phase 3 Phase 3 Efficacy Study of LNZ100 & LNZ101 for the Treatment of Presbyopia Completed
  5. Phase 3 Phase 3 Safety Study of LNZ100 and LNZ101 for the Treatment of Presbyopia Subjects Completed
  6. Phase 2 Assess the Efficacy and Safety of Repeat Intravitreal Injections of Foselutoclax (UBX1325) in Patients With DME (ASPIRE) Completed
Show 10 more trials
  1. Phase 2 INTREPID - IRay Plus Anti-VEGF Treatment For Patients With Wet AMD Completed
  2. Phase 2 Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of Presbyopia Completed
  3. Phase 2 A Study to Evaluate the Efficacy and Safety of LASN01 in Patients With Thyroid Eye Disease Completed
  4. Phase 2 Evaluation of the Safety and Effectiveness of Aceclidine (LNZ101) and Aceclidine + Brimonidine (LNZ100) in the Treatment of Presbyopia Completed
  5. Phase 1 Safety And Tolerability Study Of RN6G In Patients With Dry, Age-Related Macular Degeneration Completed
  6. Phase 1 Safety And Tolerability Study Of RN6G In Subjects With Advanced Dry, Age-Related Macular Degeneration Including Geographic Atrophy Completed
  7. N/A Feasibility Study of Retinal Screening Using the RetinaVue 100 Camera in Outpatient Dialysis Centers Completed
  8. N/A Fundus Findings and Thiol-Disulfide Homeostais Completed
  9. N/A Investigation of the Safety and Effectiveness of Monofocal Toric Intraocular Lens (IOL) Completed
  10. N/A Investigation of the Safety and Effectiveness of a Trifocal IOL Completed

Showing the 16 most-cited and recently-updated of 16 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Eye Diseases: what the trials found

Multiple trials evaluated the Aceclidine+Brimonidine combination ophthalmic solution, consistently demonstrating significant improvements in near vision. Specifically, patients showed a statistically significant increase in the percentage of participants achieving a ≥ 3-line improvement in near vision without losing ≥ 5 letters of distance vision across several studies [3, 4, 9, 10].

Clinical evaluations of Fluorometholone 0.1% Oph Susp demonstrated no statistically significant differences in incidence of postoperative tear tape (TT) use, entropion, or reoperation rates compared to control groups 1.

Early-phase studies for RN6G established safety and pharmacokinetic profiles, including measurements of plasma Amyloid (A) Beta concentrations and Prothrombin Time (PT) International Normalized Ratio (INR) [12, 13].

Recent results — preliminary, needs further review

  • LASN01 showed a response in proptosis measured by Hertel Exophthalmometer in 6% of patients and a response in Clinical Activity Score (CAS) in 15% of patients 5.
  • PODEYE TORIC Monofocal IOL demonstrated significantly lower mean residual manifest cylinder compared to control arms (p<0.0001) 6.
  • Aflibercept was evaluated in a Phase 2 trial 8.

For the clinician treating this condition

  • Aceclidine+Brimonidine combination ophthalmic solution is highly effective for improving near vision outcomes as evidenced by consistent results across multiple trials.
  • Fluorometholone 0.1% Oph Susp shows stable safety profiles regarding common surgical complications like entropion and reoperation.
  • RN6G has established baseline data regarding plasma amyloid levels and coagulation markers.

AI synthesis of 4 cited trials, updated Jun 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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