Case report details multimodal treatment for aggressive thyroid carcinoma
First new treatment combination in six months stabilizes advanced thyroid cancer
A 61-year-old man with papillary thyroid carcinoma achieved disease stabilization after thyroidectomy, radiotherapy, and targeted therapy. T…
A 61-year-old man with advanced thyroid cancer saw his disease stop growing after a specific mix of treatments within six months of his diag…
RAI therapy shifts hyperthyroidism to hypothyroidism in HRAS-mutated HGDTC with hyperfunctioning metastases
Radioactive iodine therapy helped one patient with rare thyroid cancer metastases
A case report and literature review describes a 68-year-old woman with HRAS-mutated high-grade differentiated thyroid carcinoma (HGDTC) and…
Radioactive iodine therapy successfully treated a rare case of thyroid cancer that had spread to the lungs and bones while overproducing hor…
Research across Cancer
Related studies from across the Cancer family.
CAR T-cell therapies targeting specific antigens show potential for treating pediatric CNS tumors
New CAR T-cell therapies show promise for pediatric brain tumors
This narrative review synthesizes 18 studies, including preclinical and early-phase clinical trials, regarding CAR T-cell therapy for pediat…
CAR T-cell therapy is showing potential to shrink tumors and extend life in children with aggressive brain cancers like DIPG.
Completion thyroidectomy follows total thyroidectomy for similar operative safety in differentiated thyroid cancer
Less surgery may be safer for thyroid cancer patients
This meta-analysis of 43,362 patients evaluated the surgical safety of completion thyroidectomy (CT) compared to upfront total thyroidectomy…
For some thyroid cancers, a less extensive surgery may be safer with fewer complications.
Laryngeal obstruction as initial sign of MEN2B in two pediatric cases with RET mutations
Rare genetic disorder first shows as breathing trouble in children
This case report describes 2 pediatric patients with MEN2B presenting with laryngeal obstruction and progressive respiratory compromise as i…
Two children with a rare genetic condition first showed breathing trouble from nerve growths in the airway, not the usual symptoms.
TSH suppression therapy promotes tumor progression via G-protein signaling pathways in differentiated thyroid cancer
TSH Suppression Therapy Framework for Differentiated Thyroid Cancer
This systematic review synthesizes the biological mechanisms of TSH-mediated tumor progression and proposes a clinical decision-making frame…
New research outlines how TSH levels impact thyroid cancer growth and offers a new decision-making framework for personalized patient care.
Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
Cytokine Therapies Show Potential for Treating Canine Cancers
This mini review synthesizes evidence on targeted cytokine delivery platforms, such as IL-12 and IFN-beta, in dogs with various spontaneous …
New research explores how targeted cytokine delivery systems can treat various cancers in dogs and provide data for future human cancer trea…
I-SPECT/CT shows high patient-level specificity of 0.95 for detecting residual disease in DTC
Imaging technology shows promise for detecting thyroid cancer recurrence
This meta-analysis evaluates the diagnostic efficacy of I-SPECT/CT for identifying residual or recurrent disease in patients with differenti…
A new imaging method called I-SPECT/CT helps doctors find leftover or returning thyroid cancer cells with high accuracy after treatment.
Immunohistochemical profiling helps differentiate synchronous primary breast invasive carcinoma from metastatic ovarian carcinoma
One woman diagnosed with two different types of cancer simultaneously
This case report and literature review describes a patient with concurrent primary breast cancer and metastatic high-grade serous ovarian ca…
A rare case reveals how one patient can have both breast and ovarian cancer at once, highlighting a complex diagnostic challenge.
Hemithyroidectomy is associated with a 3% higher risk difference in cancer recurrence rate
Hemithyroidectomy linked to higher thyroid cancer recurrence
This meta-analysis of 98,604 patients with differentiated thyroid carcinoma found that hemithyroidectomy (HT) was associated with a 3% highe…
A large meta-analysis found that hemithyroidectomy for differentiated thyroid cancer has a higher recurrence rate than total thyroidectomy, …
Intracranial immunotherapy delivery does not improve survival for pediatric high-grade glioma compared to systemic administration
Intracranial Delivery Shows Higher Neurotoxicity Risk in Pediatric Brain Tumors
This meta-analysis of 22 studies evaluated intracranial versus systemic immunotherapy delivery in pediatric patients with high-grade and dif…
New analysis shows that while delivery methods do not change survival for pediatric brain tumors, some routes carry a higher risk of severe …
WBRT shows no significant survival benefit in thyroid cancer brain metastases meta-analysis
Whole-brain radiation shows no clear survival benefit for thyroid cancer brain metastases
A systematic review and individual patient data meta-analysis of 247 patients with thyroid cancer brain metastases found whole-brain radiati…
Whole-brain radiation therapy showed no clear survival benefit for patients with thyroid cancer that spread to their brain.
Follicular T cell subsets and tertiary lymphoid structures may guide immunotherapy in ovarian cancer
New immune targets offer hope for ovarian cancer patients
This narrative review synthesizes evidence on follicular T cell subsets, tertiary lymphoid structures, and other immune features in ovarian …
A review highlights new immune system features that could help doctors predict treatment success and find better ways to fight ovarian cance…
Nivolumab monotherapy yielded 12-month progression-free survival in metastatic anaplastic thyroid cancer
Off-label immunotherapy may help some patients with metastatic anaplastic thyroid cancer
This case report describes a 76-year-old female with metastatic anaplastic thyroid cancer treated with off-label nivolumab monotherapy. The …
A single case report suggests off-label nivolumab helped a 76-year-old woman live longer with metastatic anaplastic thyroid cancer.