Case report details multimodal treatment for aggressive thyroid carcinoma
First new treatment combination in six months stabilizes advanced thyroid cancer
A 61-year-old man with papillary thyroid carcinoma achieved disease stabilization after thyroidectomy, radiotherapy, and targeted therapy. T…
A 61-year-old man with advanced thyroid cancer saw his disease stop growing after a specific mix of treatments within six months of his diag…
RAI therapy shifts hyperthyroidism to hypothyroidism in HRAS-mutated HGDTC with hyperfunctioning metastases
Radioactive iodine therapy helped one patient with rare thyroid cancer metastases
A case report and literature review describes a 68-year-old woman with HRAS-mutated high-grade differentiated thyroid carcinoma (HGDTC) and…
Radioactive iodine therapy successfully treated a rare case of thyroid cancer that had spread to the lungs and bones while overproducing hor…
Research across Cancer
Related studies from across the Cancer family.
Hashimoto's thyroiditis functions as a dual-natured immune microenvironment in differentiated thyroid cancer
Hashimoto's thyroiditis may both help and hinder thyroid cancer
This narrative review explores the role of Hashimoto's thyroiditis (HT) in the immune microenvironment of differentiated thyroid cancer. The…
Hashimoto's thyroiditis can act as both a shield and a sword for thyroid cancer, depending on the specific immune environment of the patient…
Systemic barriers like delayed diagnosis and limited surgery impact survival in high-grade gliomas
Systemic Barriers Impact Survival for Patients with High-Grade Gliomas
This meta-analysis of 30 independent studies evaluates survival outcomes for high-grade gliomas in low- and middle-income countries. Finding…
Limited access to surgery, chemotherapy, and early diagnosis creates significant hurdles for patients with high-grade gliomas in developing …
Radioactive iodine does not significantly reduce recurrence in low-risk differentiated thyroid cancer
Radioactive Iodine May Not Prevent Recurrence in Low-Risk Thyroid Cancer
This meta-analysis of 5260 patients evaluated the impact of radioactive iodine on recurrence and survival in low-risk differentiated thyroid…
New data suggests that radioactive iodine may not provide a significant benefit for preventing cancer recurrence in patients with low-risk t…
High tumoral PD-L1 expression correlates with increased local invasion and distant metastases in differentiated thyroid cancer
High PD-L1 levels linked to thyroid cancer spread
This meta-analysis of 12 retrospective studies indicates that high tumoral PD-L1 expression is significantly associated with lymphovascular …
New data shows that high levels of a specific protein can signal if thyroid cancer is more likely to spread locally or to distant parts of t…
Metachronous pancreatic metastasis from ovarian cancer is rare, mostly high-grade serous
Ovarian cancer can spread to pancreas, rare review finds
This systematic review of 7 studies (8 cases) found that metachronous pancreatic metastasis from ovarian cancer is rare and most often origi…
A rare spread of ovarian cancer to the pancreas may be treatable with surgery or chemo, but evidence is thin.
Reactive oxygen species promote tumorigenic programs and platinum-based chemotherapy resistance in high-grade serous ovarian cancer
Reactive Oxygen Species May Drive Ovarian Cancer Progression
This narrative review of 19 in vitro studies synthesizes how reactive oxygen species (ROS) drive tumor progression, metastatic potential, an…
New research explores how reactive oxygen species (ROS) may help ovarian cancer cells grow, spread, and resist common chemotherapy treatment…
CAR T-cell therapies targeting specific antigens show potential for treating pediatric CNS tumors
New CAR T-cell therapies show promise for pediatric brain tumors
This narrative review synthesizes 18 studies, including preclinical and early-phase clinical trials, regarding CAR T-cell therapy for pediat…
CAR T-cell therapy is showing potential to shrink tumors and extend life in children with aggressive brain cancers like DIPG.
Completion thyroidectomy follows total thyroidectomy for similar operative safety in differentiated thyroid cancer
Less surgery may be safer for thyroid cancer patients
This meta-analysis of 43,362 patients evaluated the surgical safety of completion thyroidectomy (CT) compared to upfront total thyroidectomy…
For some thyroid cancers, a less extensive surgery may be safer with fewer complications.
Laryngeal obstruction as initial sign of MEN2B in two pediatric cases with RET mutations
Rare genetic disorder first shows as breathing trouble in children
This case report describes 2 pediatric patients with MEN2B presenting with laryngeal obstruction and progressive respiratory compromise as i…
Two children with a rare genetic condition first showed breathing trouble from nerve growths in the airway, not the usual symptoms.
TSH suppression therapy promotes tumor progression via G-protein signaling pathways in differentiated thyroid cancer
TSH Suppression Therapy Framework for Differentiated Thyroid Cancer
This systematic review synthesizes the biological mechanisms of TSH-mediated tumor progression and proposes a clinical decision-making frame…
New research outlines how TSH levels impact thyroid cancer growth and offers a new decision-making framework for personalized patient care.
Targeted cytokine delivery platforms in canine oncology provide data for human immuno-oncology dose selection
Cytokine Therapies Show Potential for Treating Canine Cancers
This mini review synthesizes evidence on targeted cytokine delivery platforms, such as IL-12 and IFN-beta, in dogs with various spontaneous …
New research explores how targeted cytokine delivery systems can treat various cancers in dogs and provide data for future human cancer trea…
I-SPECT/CT shows high patient-level specificity of 0.95 for detecting residual disease in DTC
Imaging technology shows promise for detecting thyroid cancer recurrence
This meta-analysis evaluates the diagnostic efficacy of I-SPECT/CT for identifying residual or recurrent disease in patients with differenti…
A new imaging method called I-SPECT/CT helps doctors find leftover or returning thyroid cancer cells with high accuracy after treatment.