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Home › Conditions › high-grade squamous intraepithelial lesions

High-grade squamous intraepithelial lesions

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for high-grade squamous intraepithelial lesions

2 trials tracked for high-grade squamous intraepithelial lesions: 2 in phase 3 or 4 and 2 with published results. The most-cited published study has 463 citations.

2Trials tracked
2Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 2
  1. Phase 3 Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions Completed · 463 cited
  2. Phase 3 Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions Completed · 3 cited

Showing the 2 most-cited and recently-updated of 2 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Review of botanical drugs targeting cervical HPV infection and lesions
Drug Pipeline Sys. Review
Review of botanical drugs targeting cervical HPV infection and lesions New plant compounds may help clear stubborn HPV infections before cancer starts
This review examines botanical drugs and their bioactive metabolites for cervical HPV infection, high-grade squamous intraepithelial lesions…
Researchers found that specific plant medicines might help the body clear the HPV virus that causes cervical cancer
Frontiers Apr 30, 2026
CLEC14A methylation marker detects HSIL and cervical cancer with 100% sensitivity and 95.3% specificity in a cohort of 431 participants
Oncology Cohort
CLEC14A methylation marker detects HSIL and cervical cancer with 100% sensitivity and 95.3% specificity in a cohort of 431 participants Can a simple blood test spot dangerous cervical cell changes before they become cancer?
This cohort study of 431 participants evaluated the CLEC14A cg05057720 methylation marker for detecting high-grade squamous intraepithelial …
A new blood test marker detects every case of dangerous cervical cell changes while correctly identifying normal tissue in over 95% of cases…
Frontiers Apr 16, 2026
Cervical blockade reduces pain and bleeding during LEEP for HSIL in small RCT
OB/GYN & Women's Health RCT
Cervical blockade reduces pain and bleeding during LEEP for HSIL in small RCT Local cervical anesthesia reduces pain and bleeding during cervical surgery
A small, open-label RCT of 40 patients with HSIL undergoing LEEP found that adding cervical blockade to general anesthesia significantly red…
Adding local anesthesia to cervical surgery reduced pain and bleeding during the procedure for patients having LEEP to remove abnormal cells…
Apr 8, 2026