Balanced human microbiota supports regulatory T-cell responses and barrier integrity in immune-mediated diseases
Healthy Gut Bacteria Help Protect the Body Against Immune System Problems
This narrative review explores the role of the human microbiota in immune-mediated diseases. The authors conclude that a balanced microbiota…
Your gut bacteria play a huge role in keeping your immune system healthy and strong. A balanced gut helps your body fight off germs and stay…
Anti-rituximab antibodies are associated with lower rituximab levels and increased relapse rates in nephropathies
Antibodies may impact how well rituximab treats certain kidney diseases
This narrative review examines the prevalence and clinical implications of anti-rituximab antibodies (ADAs) in patients with nephropathies a…
Certain antibodies can lower the effectiveness of rituximab and lead to more frequent relapses in patients with kidney and immune diseases.
High-resolution HLA variation analysis identifies 1,461 significant associations with immune-mediated disease phenotypes
Genetic Markers Linked to Immune Mediated Diseases in Large Study
This meta-analysis of data from the All of Us Research Program analyzes high-resolution HLA variations across six genetic ancestry groups. T…
A large-scale analysis of over 390,000 people identified thousands of genetic links between specific immune markers and various health condi…
CAR T-cell optimization strategies are reviewed for hematologic cancers, solid tumors, and immune-mediated diseases
Can fixing CAR T-cells in multiple ways finally make them safer and more effective for cancer patients?
This systematic review evaluates CAR T-cell therapy optimization strategies involving genetic, epigenetic, metabolic, and microenvironmental…
Fixing CAR T-cells across genetics, metabolism, and environment offers a safer, more effective path for treating blood cancers, solid tumors…
Questions about immune-mediated diseases
What are the optimization strategies for CAR T-cell therapy in immune-mediated diseases?
Optimization of CAR T-cell therapy for immune-mediated diseases focuses on improving safety, precision, and durability through genetic engineering, metabolic reprogramming, and transient expression methods.
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