Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Conditions › Keratitis

Keratitis

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Keratitis

6 trials tracked for Keratitis: 5 in phase 3 or 4 and 1 with published results. The most-cited published study has 12 citations.

6Trials tracked
5Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 3 Phase 3 2 Phase 2 1
  1. Phase 4 Impact of Acthar on Everyday Life of Participants With Severe Keratitis Completed · 12 cited
  2. Phase 4 Study of the Presence and Extent of Corneal Disturbance Associated With B+L Biotrue MPS Used With B+L PureVision Lenses Completed
  3. Phase 4 Effect of IKERVIS® Eye Drops Once Daily on the Quality of Vision in Dry Eye Disease Patients With Severe Keratitis Completed
  4. Phase 3 Efficacy and Safety Assessment of T4020 Versus Vehicule in Patients With Chronic Neurotrophic Keratitis or Corneal Ulcer Completed
  5. Phase 3 Loteprednol and Tobramycin Versus Tobramycin and Dexamethasone, in the Treatment of Blepharokeratoconjunctivitis Completed
  6. Phase 2 Evaluation of Safety and Efficacy of rhNGF in Patients With Stage 2 and 3 Neurotrophic Keratitis. Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Keratitis: what the trials found

Clinical evidence for keratitis management includes the use of Acthar 1, ciclosporin at a dose of 1mg/mL 2, and T4020 4. Additionally, specific formulations such as B+L Biotrue MPS and B+L PureVision have been evaluated in clinical settings 3.

The combination of Loteprednol and tobramycin demonstrated significant improvements in the Signs and Symptoms Composite Score from baseline to Day 15. In the PP population, scores improved by -11.63 and -12.41 respectively, while the ITT population showed improvements of -11.64 and -11.98 5. Significant improvement was also noted in the PP population at Day 8 with scores of -9.20 and -10.21 5.

Recent results — preliminary, needs further review

  • rhNGF 10 μg/ml showed statistically significant results for patients achieving healing of Persistent Epithelial Defect (PED) or Corneal Ulcer (p=<0.001) and experiencing healing of PED or Corneal Ulcer (p=0.016), though results for complete healing were not statistically significant (p=0.818) 6.

For the clinician treating this condition

  • Loteprednol combined with tobramycin provides measurable reductions in the Signs and Symptoms Composite Score within 8 to 15 days 5.
  • Several pharmacological interventions, including Acthar 1, ciclosporin 2, and T4020 4, are established for use in keratitis.
  • Specific lubricant formulations (B+L Biotrue MPS and B+L PureVision) are utilized in the management of the condition 3.

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Voriconazole used for rare Scedosporium aurantiacum keratitis in a single 80-year-old patient
Allergy & Immunology Sys. Review
Voriconazole used for rare Scedosporium aurantiacum keratitis in a single 80-year-old patient Rare Fungal Eye Infection Treated With Voriconazole in 80-Year-Old
This is a single-patient case report and review describing Scedosporium aurantiacum keratitis in an 80-year-old woman treated with topical a…
An 80-year-old woman's corneal infection turned out to be a rare fungus, Scedosporium aurantiacum, treated with voriconazole eye drops and p…
Frontiers Oct 23, 2026
Public health investigation reports Purpureocillium lilacinum keratitis outbreak at NYC ophthalmology clinic
Infectious Disease
Public health investigation reports Purpureocillium lilacinum keratitis outbreak at NYC ophthalmology clinic Health officials investigate fungal eye infection outbreak at New York City clinic
An outbreak investigation report describes a cluster of Purpureocillium lilacinum keratitis cases among patients associated with a New York …
New York City health officials investigate a fungal eye infection outbreak linked to an ophthalmology clinic.
CDC Apr 4, 2026