Research across Kidney Diseases
Related studies from across the Kidney Diseases family.
Intermittent Hemodialysis Falls Short of Continuous Therapy in Critically Ill AKI Trial
Trial shows continuous renal-replacement therapy may reduce kidney injury mortality
In critically ill adults with acute kidney injury, intermittent hemodialysis did not prove noninferior to continuous therapy and was linked …
A trial of 554 critically ill adults found that continuous renal-replacement therapy was associated with lower mortality rates than intermit…
nsMRAs reduce UACR and systolic BP in patients with diabetic kidney disease
New medication class shows promise for diabetic kidney disease
This meta-analysis of 15,143 patients found that nsMRAs reduced log-transformed UACR by 0.36 mg/g and systolic BP by 4.72 mmHg in patients w…
A new class of drugs may lower blood pressure and protein in the urine for people with diabetic kidney disease, though some risks exist.
Metabolic profiles and specific metabolites serve as potential biomarkers for diabetic kidney disease progression
Metabolites May Help Identify New Pathways in Diabetic Kidney Disease
This systematic review synthesizes the roles of metabolites as signaling hubs and substrates for epigenetic modifications in diabetic kidney…
New research identifies how specific metabolites act as signaling hubs that could help doctors better predict and treat diabetic kidney dise…
Monocyte and macrophage sensing of calciprotein particles triggers inflammasome activation and interleukin-1β release
Immune Cells and Calcium Particles May Drive Damage in Kidney Disease
This mini-review synthesizes evidence regarding how monocytes and macrophages respond to calciprotein particles (CPPs). The review details m…
New research shows how certain immune cells react to calcium particles, potentially causing inflammation and tissue damage in kidney patient…
Unhealthy food environments and ultra-processed foods contribute to obesity and related cardiometabolic diseases
Food Environments Linked to Obesity and Type 2 Diabetes
This narrative review examines how food environment factors like accessibility and affordability influence the consumption of ultra-processe…
Unhealthy food environments and ultra-processed foods are linked to serious conditions like insulin resistance, heart disease, and chronic k…
suPAR predicts incident CKD and ESKD in adults with preserved kidney function
suPAR Levels May Predict Risk of Chronic Kidney Disease
This systematic review of 31,416 patients found that suPAR predicts incident CKD (OR 3.13) and ESKD (HR 1.53) in adults with preserved kidne…
A large review suggests that suPAR levels can help predict the risk of developing chronic kidney disease and end-stage kidney disease in som…
Resistance training improves eGFR in non-dialysis diabetic kidney disease while mind-body exercise reduces UAE
Specific types of exercise may help manage diabetic kidney disease
This systematic review and network meta-analysis of 1,746 patients found that resistance training significantly increased eGFR compared to u…
Different types of exercise, from resistance training to mind-body practices, show different benefits for managing diabetic kidney disease a…
RAAS inhibitors modulate inflammatory responses and oxidative stress across multiple chronic conditions
RAAS Inhibitors May Protect Organs Beyond Lowering Blood Pressure
This systematic review synthesizes the roles of ACEI, ARB, DRI, ARNI, and MRA in modulating inflammatory responses and oxidative stress. The…
New research suggests certain blood pressure medications may protect the heart, kidneys, and lungs by reducing inflammation and oxidative st…
Glutamine metabolism serves as a critical energy substrate and potential therapeutic target in AKI and CKD
Glutamine Metabolism May Offer New Insights for Kidney Disease
This narrative review explores the role of glutamine metabolism in acute kidney injury and chronic kidney disease. The authors suggest that …
New research into glutamine metabolism suggests potential new ways to manage and treat acute and chronic kidney diseases.
Multiple biomarkers show potential associations with kidney function decline in patients with type 2 diabetes
Specific Biomarkers May Signal Kidney Decline in Type 2 Diabetes
This systematic review and meta-analysis of 4,569 patients evaluated several biomarkers for detecting kidney function decline in type 2 diab…
New research identifies several biomarkers that may help detect early signs of kidney function decline in people with type 2 diabetes.
Hemodiafiltration in Neonates: Narrative Review Maps Applications but Reports No Clinical Outcomes
Hemodiafiltration in Babies: What We Still Do Not Know
This narrative review examines hemodiafiltration (HDF) in neonates and infants, focusing on clinical applications, potential benefits, safet…
A new review looks at hemodiafiltration for newborns and infants, but reports no actual results or safety data.
HIF-prolyl hydroxylase inhibitors cause modest VEGF increases and reproducible peripheral edema in chronic kidney disease
New data shows how kidney disease drugs affect blood levels
This meta-analysis of 34 randomized controlled trials evaluated HIF-prolyl hydroxylase inhibitors in patients with chronic kidney disease. T…
A review of 34 trials shows that a specific type of kidney medication increases a protein called VEGF, but also carries a risk of swelling.