Phase 2a trial of dazodalibep plus belatacept shows 25% acute rejection rate in kidney transplant patients
Early study tests two-drug combination to prevent kidney transplant rejection
A phase 2a, open-label, single-arm trial in 23 adults undergoing first kidney transplants evaluated dazodalibep plus belatacept as sole main…
A new two-drug kidney treatment was safe but failed to prevent rejection in most patients during this early study.
Metabolic syndrome associated with higher cardio-renal risk in kidney transplant recipients
Metabolic syndrome linked to higher risks for heart problems and kidney graft issues after transplant
A meta-analysis of 8,986 kidney transplant recipients found metabolic syndrome was associated with higher risks of major adverse cardiovascu…
Kidney transplant patients with metabolic syndrome face double the risk of major heart events and higher chances of graft failure or death.
Synbiotics Reduce Inflammation and Intestinal Permeability in Kidney Transplant Recipients
Could synbiotics help kidney transplant patients feel better and reduce inflammation?
In a trial with 46 kidney transplant recipients, synbiotic supplementation for 12 weeks significantly reduced serum LBP, hs-CRP, IL-6, and s…
For kidney transplant recipients, synbiotics may lower harmful inflammation and improve gut health. This could mean better overall health an…
Research across Chronic Kidney Disease
Related studies from across the Chronic Kidney Disease family.
Gut-kidney axis drives sepsis-associated AKI, review argues for microecological and neuromodulatory therapies
New Approaches Target Gut Health to Treat Sepsis Kidney Damage
This systematic review examines the gut-kidney axis as a mechanistic driver of sepsis-associated acute kidney injury and evaluates microecol…
New research explores how targeting the gut-kidney axis could help treat and prevent kidney damage in patients with sepsis.
Four mailer types aim to increase health care proxy documentation in patients with chronic conditions
New trial plans to use mailers to help patients name proxies
This study protocol describes a factorial randomized trial of approximately 20,000 patients with cancer, congestive heart failure, or chroni…
A new study plans to see if different types of mailers can help patients with serious illnesses name a healthcare proxy.
High abdominal aortic calcification index predicts poorer cardiovascular event-free survival in patients with chronic kidney disease
High Abdominal Aortic Calcification Linked to Worse Outcomes in Kidney Disease
This meta-analysis of 1,914 patients found that high abdominal aortic calcification index (ACI) is associated with significantly worse cardi…
High levels of calcium buildup in the aorta are linked to a higher risk of heart issues and lower survival in patients with chronic kidney d…
Pegylated erythropoietin provides improved Hb stability and reduced dosing frequency in CKD-related anemia
Expert Consensus Shows Pegylated Erythropoietin Benefits Chronic Kidney Disease Patients
This expert consensus evaluates the use of pegylated erythropoietin for CKD-related anemia in India. The consensus indicates that pegylated …
A new expert consensus suggests that pegylated erythropoietin can improve hemoglobin stability and reduce dosing frequency for patients with…
CABG reduces all-cause death and repeat revascularisation risk in patients with diabetes and CKD
CABG Shows Lower Risk for Patients with Diabetes and CKD
This systematic review and meta-analysis of 10594 patients with multivessel coronary disease and multiple long-term conditions found CABG fa…
Surgery may offer better outcomes than other procedures for patients with heart disease who also have diabetes and chronic kidney disease.
Elevated Visceral Adiposity Index is associated with increased risk of diabetic kidney disease
High visceral fat levels linked to higher risk of kidney disease
This meta-analysis of 58,312 participants found that an elevated Visceral Adiposity Index (VAI) is associated with an increased risk of diab…
A large study of over 58,000 people links a specific measure of internal body fat to a higher risk of diabetic kidney disease.
AVF ligation reduces left ventricular mass index by 10.92 g/m in end-stage kidney disease
AVF Ligation Linked to Better Heart Health in Kidney Patients
This meta-analysis of 844 patients with end-stage kidney disease and high-flow arteriovenous fistulas found that AVF ligation was associated…
A review of clinical data suggests that closing certain blood vessels may improve heart structure for patients with end-stage kidney disease…
Vitamin D deficiency is associated with 33% higher odds of progression in chronic kidney disease
Vitamin D Deficiency Linked to Faster Chronic Kidney Disease Progression
This meta-analysis of observational studies indicates that vitamin D deficiency is associated with a 33% higher risk of progression in patie…
Low vitamin D levels are linked to a 33% higher risk of progression in patients with chronic kidney disease.
Pre-stenting increases FANS-UAS placement success from 80.0% to 94.8% in RIRS for kidney stones
Pre-stenting improves success rates for kidney stone surgery
This randomized controlled trial of 221 patients undergoing retrograde intrarenal surgery found that pre-stenting significantly improved FAN…
A new study shows that placing a stent before kidney stone surgery can make it easier for doctors to access stones and place necessary tools…
Exercise training increases circulating s-Klotho levels in adults with CKD and sarcopenia
Exercise Training Increases Klotho Levels in People with Kidney Disease
This meta-analysis of 893 participants evaluated the impact of various exercise modalities on s-Klotho and FGF23 levels. The analysis found …
Regular exercise training, including resistance and high-intensity intervals, may increase Klotho levels in adults with kidney disease and d…
Targeted strategies like senolytics and PFKFB3 blockers show preclinical efficacy in chronic kidney disease
New research explores how cells drive chronic kidney disease
This narrative review explores the mechanisms of necroptotic tubular epithelial cell death and glycolytic reprogramming in chronic kidney di…
Scientists identified a self-amplifying cycle of cell death and aging that drives scarring in chronic kidney disease.
Periodontal conditions and plaque index correlate with lower oral health-related quality of life in ESRD patients
Periodontitis Linked to Lower Oral Quality of Life in Kidney Patients
This meta-analysis of 7 studies identifies that patients with end-stage renal disease (ESRD) report higher OHIP-14 scores compared to health…
Patients with end-stage renal disease and severe gum disease may experience a lower quality of life regarding their oral health.
Questions about Kidney Transplant Rejection
Does having metabolic syndrome increase the risk of rejection in kidney transplant recipients?
Metabolic syndrome increases the risk of acute kidney graft rejection, along with higher risks of heart problems and death in transplant recipients.
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