Phase 2a trial of dazodalibep plus belatacept shows 25% acute rejection rate in kidney transplant patients
Early study tests two-drug combination to prevent kidney transplant rejection
A phase 2a, open-label, single-arm trial in 23 adults undergoing first kidney transplants evaluated dazodalibep plus belatacept as sole main…
A new two-drug kidney treatment was safe but failed to prevent rejection in most patients during this early study.
Metabolic syndrome associated with higher cardio-renal risk in kidney transplant recipients
Metabolic syndrome linked to higher risks for heart problems and kidney graft issues after transplant
A meta-analysis of 8,986 kidney transplant recipients found metabolic syndrome was associated with higher risks of major adverse cardiovascu…
Kidney transplant patients with metabolic syndrome face double the risk of major heart events and higher chances of graft failure or death.
Synbiotics Reduce Inflammation and Intestinal Permeability in Kidney Transplant Recipients
Could synbiotics help kidney transplant patients feel better and reduce inflammation?
In a trial with 46 kidney transplant recipients, synbiotic supplementation for 12 weeks significantly reduced serum LBP, hs-CRP, IL-6, and s…
For kidney transplant recipients, synbiotics may lower harmful inflammation and improve gut health. This could mean better overall health an…
Research across Chronic Kidney Disease
Related studies from across the Chronic Kidney Disease family.
Insulin resistance and hyperinsulinemia drive bidirectional links between biological aging and age-related chronic diseases
Insulin Resistance Links Aging and Chronic Diseases
This narrative review explores the reciprocal relationship between insulin resistance, hyperinsulinemia, and mechanisms of biological aging.…
This review explores how insulin resistance and high insulin levels connect aging to diseases like diabetes, heart disease, and kidney disea…
Frailty associated with higher odds of cognitive impairment in patients with chronic kidney disease
Frailty increases risk of cognitive issues in kidney disease patients
This meta-analysis of 129,868 patients with chronic kidney disease (CKD) found that frailty is associated with a significantly higher risk o…
People with chronic kidney disease who experience frailty are much more likely to face memory and thinking problems than those who stay robu…
Chronic kidney disease prevalence of 13.7% identified across 19 African countries
New data shows high rates of kidney disease across Africa
This systematic review and meta-analysis of 91,723 adults in Africa found a pooled CKD prevalence of 13.7% for stages 1 to 5. The study also…
A large-scale review reveals that over 13% of adults in many African countries live with chronic kidney disease.
GLP-1 receptor agonists and tirzepatide provide cardiovascular benefits across multiple clinical scenarios
Incretin Drugs Show Heart Benefits Across Multiple Conditions
This state-of-the-art review synthesizes evidence regarding incretin analogues, specifically GLP-1 receptor agonists and tirzepatide. The re…
GLP-1 drugs and tirzepatide prove heart benefits in diabetes, obesity, heart failure, and more.
Natural products offer multi-target renoprotective effects for metabolic, inflammatory, and oxidative stress pathways
Natural compounds show promise for kidney disease
This systematic review examines the role of natural products including polysaccharides, flavonoids, and phenolic acids in managing diabetic …
Natural compounds from plants may help protect kidneys by targeting multiple disease pathways at once.
Inflammation and immune dysregulation drive chronic kidney disease progression and associated tissue remodeling
Inflammation and Immune Issues Drive Chronic Kidney Disease Progression
This mini review synthesizes the role of inflammation and immune dysregulation in the initiation and progression of chronic kidney disease. …
Persistent inflammation and immune system issues are central drivers of chronic kidney disease, leading to tissue damage and potential compl…
Herbal Medicinal Bath shows stable efficacy for chronic kidney disease-associated pruritus in network meta-analysis
Herbal medicinal baths may relieve itching in kidney disease
This systematic review and network meta-analysis of 1,968 patients evaluated 12 complementary therapies for chronic kidney disease-associate…
New research suggests herbal medicinal baths are a reliable way to soothe persistent itching for people with chronic kidney disease.
Finerenone Efficacy and Safety in Patients with Chronic Kidney Disease and Glomerular Disease
Finerenone slows kidney function loss in patients with glomerular disease
Finerenone significantly slows eGFR decline and reduces albuminuria in patients with glomerular disease, offering a new therapeutic option f…
A new clinical trial shows that the medication finerenone helps slow kidney decline and reduces protein in the urine for people with specifi…
Vitamin D supplementation shows low certainty reductions in urinary markers for diabetic kidney disease
Vitamin D shows limited benefit for diabetic kidney disease
This umbrella review meta-analysis evaluates vitamin D and its analogs in patients with diabetic kidney disease. While some reduction in uri…
Vitamin D may lower protein in urine for diabetic kidney disease, but evidence is weak and no benefit for kidney function or survival.
Unified cardiometabolic disease framework links T2DM, ASCVD, HFpEF, MASLD, hypertension, and CKD via shared pathophysiology
New Framework Links Heart and Kidney Health in Diabetes
This guideline provides a narrative review of the unified cardiometabolic disease (UCD) continuum. It argues that conditions like T2DM, ASCV…
Experts suggest that diabetes, heart failure, and kidney disease may share a single underlying cause rather than being separate conditions.
Age, male sex, low BMI, and comorbidities like diabetes are significant risk factors for sepsis incidence
Age, diabetes, and COPD raise sepsis risk, meta-analysis finds
This meta-analysis of 21 studies identifies several significant risk factors associated with increased sepsis incidence, including age over …
A new analysis of 21 studies pinpoints key risk factors for sepsis, including age, diabetes, and COPD.
m6A modification regulates renal tubular epithelial cell fate and inflammatory responses in acute kidney injury
Gene modification may drive kidney injury, review finds
This systematic review examines the role of N6-methyladenosine (m6A) modification in the progression of acute kidney injury. The authors con…
A new review reveals that a chemical modification to RNA, called m6A, plays a key role in acute kidney injury by affecting cell death and in…
Questions about Kidney Transplant Rejection
Does having metabolic syndrome increase the risk of rejection in kidney transplant recipients?
Metabolic syndrome increases the risk of acute kidney graft rejection, along with higher risks of heart problems and death in transplant recipients.
Full answer →