Phase 2a trial of dazodalibep plus belatacept shows 25% acute rejection rate in kidney transplant patients
Early study tests two-drug combination to prevent kidney transplant rejection
A phase 2a, open-label, single-arm trial in 23 adults undergoing first kidney transplants evaluated dazodalibep plus belatacept as sole main…
A new two-drug kidney treatment was safe but failed to prevent rejection in most patients during this early study.
Metabolic syndrome associated with higher cardio-renal risk in kidney transplant recipients
Metabolic syndrome linked to higher risks for heart problems and kidney graft issues after transplant
A meta-analysis of 8,986 kidney transplant recipients found metabolic syndrome was associated with higher risks of major adverse cardiovascu…
Kidney transplant patients with metabolic syndrome face double the risk of major heart events and higher chances of graft failure or death.
Synbiotics Reduce Inflammation and Intestinal Permeability in Kidney Transplant Recipients
Could synbiotics help kidney transplant patients feel better and reduce inflammation?
In a trial with 46 kidney transplant recipients, synbiotic supplementation for 12 weeks significantly reduced serum LBP, hs-CRP, IL-6, and s…
For kidney transplant recipients, synbiotics may lower harmful inflammation and improve gut health. This could mean better overall health an…
Research across Chronic Kidney Disease
Related studies from across the Chronic Kidney Disease family.
Metabolic profiles and specific metabolites serve as potential biomarkers for diabetic kidney disease progression
Metabolites May Help Identify New Pathways in Diabetic Kidney Disease
This systematic review synthesizes the roles of metabolites as signaling hubs and substrates for epigenetic modifications in diabetic kidney…
New research identifies how specific metabolites act as signaling hubs that could help doctors better predict and treat diabetic kidney dise…
Monocyte and macrophage sensing of calciprotein particles triggers inflammasome activation and interleukin-1β release
Immune Cells and Calcium Particles May Drive Damage in Kidney Disease
This mini-review synthesizes evidence regarding how monocytes and macrophages respond to calciprotein particles (CPPs). The review details m…
New research shows how certain immune cells react to calcium particles, potentially causing inflammation and tissue damage in kidney patient…
Unhealthy food environments and ultra-processed foods contribute to obesity and related cardiometabolic diseases
Food Environments Linked to Obesity and Type 2 Diabetes
This narrative review examines how food environment factors like accessibility and affordability influence the consumption of ultra-processe…
Unhealthy food environments and ultra-processed foods are linked to serious conditions like insulin resistance, heart disease, and chronic k…
suPAR predicts incident CKD and ESKD in adults with preserved kidney function
suPAR Levels May Predict Risk of Chronic Kidney Disease
This systematic review of 31,416 patients found that suPAR predicts incident CKD (OR 3.13) and ESKD (HR 1.53) in adults with preserved kidne…
A large review suggests that suPAR levels can help predict the risk of developing chronic kidney disease and end-stage kidney disease in som…
Resistance training improves eGFR in non-dialysis diabetic kidney disease while mind-body exercise reduces UAE
Specific types of exercise may help manage diabetic kidney disease
This systematic review and network meta-analysis of 1,746 patients found that resistance training significantly increased eGFR compared to u…
Different types of exercise, from resistance training to mind-body practices, show different benefits for managing diabetic kidney disease a…
RAAS inhibitors modulate inflammatory responses and oxidative stress across multiple chronic conditions
RAAS Inhibitors May Protect Organs Beyond Lowering Blood Pressure
This systematic review synthesizes the roles of ACEI, ARB, DRI, ARNI, and MRA in modulating inflammatory responses and oxidative stress. The…
New research suggests certain blood pressure medications may protect the heart, kidneys, and lungs by reducing inflammation and oxidative st…
Glutamine metabolism serves as a critical energy substrate and potential therapeutic target in AKI and CKD
Glutamine Metabolism May Offer New Insights for Kidney Disease
This narrative review explores the role of glutamine metabolism in acute kidney injury and chronic kidney disease. The authors suggest that …
New research into glutamine metabolism suggests potential new ways to manage and treat acute and chronic kidney diseases.
Multiple biomarkers show potential associations with kidney function decline in patients with type 2 diabetes
Specific Biomarkers May Signal Kidney Decline in Type 2 Diabetes
This systematic review and meta-analysis of 4,569 patients evaluated several biomarkers for detecting kidney function decline in type 2 diab…
New research identifies several biomarkers that may help detect early signs of kidney function decline in people with type 2 diabetes.
Hemodiafiltration in Neonates: Narrative Review Maps Applications but Reports No Clinical Outcomes
Hemodiafiltration in Babies: What We Still Do Not Know
This narrative review examines hemodiafiltration (HDF) in neonates and infants, focusing on clinical applications, potential benefits, safet…
A new review looks at hemodiafiltration for newborns and infants, but reports no actual results or safety data.
HIF-prolyl hydroxylase inhibitors cause modest VEGF increases and reproducible peripheral edema in chronic kidney disease
New data shows how kidney disease drugs affect blood levels
This meta-analysis of 34 randomized controlled trials evaluated HIF-prolyl hydroxylase inhibitors in patients with chronic kidney disease. T…
A review of 34 trials shows that a specific type of kidney medication increases a protein called VEGF, but also carries a risk of swelling.
Mineralocorticoid receptor antagonists exert cardioprotective effects by restoring coronary microvascular function
Mineralocorticoid Receptor Antagonists May Improve Heart Function in Heart Failure
This mini-review examines the mechanisms of mineralocorticoid receptor antagonists in patients with heart failure, hypertension, and chronic…
New research highlights how mineralocorticoid receptor antagonists may protect the heart by improving blood flow in small vessels for patien…
Higher H3.1 nucleosome levels associate with 48% increased 28-day mortality in septic shock
H3.1 Nucleosome Levels Linked to Sepsis Mortality and Kidney Risk
This secondary analysis of a multicenter randomized controlled trial involved 971 patients with sepsis and septic shock. Higher plasma H3.1 …
Higher levels of H3.1 nucleosomes in patients with sepsis and septic shock are linked to a higher risk of death and need for kidney replacem…
Questions about Kidney Transplant Rejection
Does having metabolic syndrome increase the risk of rejection in kidney transplant recipients?
Metabolic syndrome increases the risk of acute kidney graft rejection, along with higher risks of heart problems and death in transplant recipients.
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