Research across Cancer
Related studies from across the Cancer family.
Encorafenib and Binimetinib Combination Therapy for Patients with BRAF Mutated Cutaneous Melanoma
Trial Shows Encorafenib and Binimetinib for Melanoma Patients
This trial evaluates the safety and efficacy of encorafenib and binimetinib in patients with resected stage IIB/IIC melanoma.
A clinical trial shows that a combination of encorafenib and binimetinib may improve recurrence-free survival for patients with specific mel…
Objective response rate correlates with overall survival in nivolumab-containing regimens for metastatic melanoma
Nivolumab regimens show link between tumor shrinkage and melanoma survival
This meta-analysis of 1865 treatment-naive patients with metastatic melanoma evaluated the association between clinical surrogates and overa…
New data shows that shrinking tumors and staying stable provides a strong link to longer survival for patients with metastatic melanoma.
Mitophagy acts as a core barrier to effective immunotherapy in melanoma and other skin cancers
Mitophagy acts as a barrier to skin cancer immunotherapy
This narrative review explores how mitophagy functions as a barrier to immunotherapy in melanoma, cutaneous squamous cell carcinoma, and bas…
A cellular process called mitophagy may help skin cancers hide from the immune system, making it harder for certain treatments to work.
PGE2 signaling via EP receptors drives tumor progression and context-dependent neuroinflammation in various diseases
Understanding the Role of PGE2 Signaling in Brain Health and Cancer
This systematic review examines the role of PGE2 signaling across neurological, oncological, and metabolic conditions. The findings indicate…
New research shows how different parts of a single protein pathway can either protect your brain or help tumors grow.
mRNA vaccines offer a flexible and rapid production platform for personalized melanoma immunotherapy
mRNA Vaccines Show Promise for Treating Melanoma Cancer
This systematic review examines mRNA cancer vaccines, including lipid nanoparticle delivery systems, as potential treatments for melanoma. T…
New research highlights mRNA technology as a flexible and fast way to develop personalized treatments for melanoma patients.
Fecal microbiota transplantation may modulate tumor microenvironment and enhance immunotherapy responses in several cancers
Fecal Microbiota Transplantation Shows Potential for Several Cancer Treatments
This systematic review explores the role of fecal microbiota transplantation (FMT) in treating colorectal cancer, liver cancer, and melanoma…
Fecal microbiota transplantation may help manage side effects and improve how the body responds to cancer treatments like chemotherapy and i…
Pregnancy-associated melanoma does not independently worsen overall survival when stage is adequately controlled
Pregnancy associated melanoma does not lower overall survival rates
This meta-analysis of observational studies involving 16,467 women found no significant difference in overall survival for patients with pre…
New data shows that a melanoma diagnosis during or shortly after pregnancy does not change the long-term survival outlook for women.
CD73-adenosine axis serves as a metabolic immune checkpoint and potential target to overcome melanoma resistance
CD73 Target May Help Overcome Melanoma Treatment Resistance
This systematic review examines the role of the CD73-adenosine axis in advanced melanoma and its implications for treatment resistance. The …
New research explores how blocking the CD73-adenosine axis could help patients with advanced melanoma overcome resistance to current treatme…
AI-assisted clinicians achieve 1.000 sensitivity in melanoma diagnosis but autonomous AI lacks clear clinical advantage
Artificial Intelligence Shows Mixed Results in Detecting Melanoma
This meta-analysis of 17 diagnostic arms from 10 studies evaluates artificial intelligence for dermoscopic image analysis in melanoma detect…
New research shows that while AI can help identify skin cancer, it does not yet outperform traditional methods used by doctors.
Opsin 3 serves as a potential therapeutic target for melanoma and inflammatory skin diseases
Opsin 3 May Offer New Path for Skin Disease Treatment
This narrative review explores the role of Opsin 3 (OPN3) in skin pathophysiology, including its involvement in UV damage, melanoma developm…
A protein called Opsin 3 may play a key role in how skin cells respond to UV damage, aging, and inflammation.
AI diagnostic tools show high accuracy but limited real-world validation in systematic review
Artificial intelligence shows high accuracy in detecting various medical conditions
This systematic review of 24 studies synthesizes evidence on AI and deep learning for disease detection across multiple imaging modalities. …
New analysis of 24 studies shows AI tools can reach over 90% accuracy in spotting everything from lung cancer to skin disorders.
Actinic keratosis increases melanoma risk while alcohol consumption is associated with lower squamous cell carcinoma risk
Actinic Keratosis Linked to Higher Risk of Melanoma
This meta-analysis of genome-wide association studies evaluates causal relationships between 11 modifiable risk factors and skin cancers. Th…
New research identifies a link between actinic keratosis and melanoma risk while highlighting potential new targets for skin cancer treatmen…