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Home › Conditions › Merkel Cell Carcinoma

Merkel Cell Carcinoma

Part of Germ cell tumors

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Merkel Cell Carcinoma

7 trials tracked for Merkel Cell Carcinoma: 1 in phase 3 or 4 and 1 with published results. The most-cited published study has 9 citations.

7Trials tracked
1Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 3 1 Phase 2 5 Other / NA 1
  1. Phase 3 Pembrolizumab (MK-3475) as First-line Therapy for Advanced Merkel Cell Carcinoma (MK-3475-913) Completed · 9 cited
  2. Phase 2 A Study of Tremelimumab and IV Durvalumab Plus Poly-ICLC in Subjects With Biopsy-accessible Cancers Completed
  3. Phase 2 Avelumab in Participants With Merkel Cell Carcinoma (JAVELIN Merkel 200) Completed
  4. Phase 2 A Study of T-VEC (Talimogene Laherparepvec) With or Without Radiotherapy for Melanoma, Merkel Cell Carcinoma, or Other Solid Tumors Completed
  5. Phase 2 MLN0128 in Recurrent/Metastatic Merkel Cell Carcinoma Completed
  6. Phase 2 IL-12 Gene and in Vivo Electroporation-Mediated Plasmid DNA Vaccine Therapy in Patients With Merkel Cell Cancer Completed
Show 1 more trials
  1. N/A The Impact of Total Body Skin Examination on Skin Cancer Detection Completed

Showing the 7 most-cited and recently-updated of 7 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Nodal staging in upper eyelid Merkel cell carcinoma may influence disease-free status and survival outcomes
Oncology Guideline
Nodal staging in upper eyelid Merkel cell carcinoma may influence disease-free status and survival outcomes Eyelid cancer cases show importance of staging for survival
This case report describes 3 patients with upper eyelid Merkel cell carcinoma undergoing wide local excision and reconstruction. One patient…
A small study of eyelid cancer shows that skipping certain staging steps can lead to rapid spread and death.
Frontiers Sep 14, 2026
DNA vaccines against MCPyV LTAg and STAg show potential for Merkel cell carcinoma immunotherapy
Allergy & Immunology Guideline
DNA vaccines against MCPyV LTAg and STAg show potential for Merkel cell carcinoma immunotherapy DNA Vaccines Show Promise Against Merkel Cell Carcinoma in Mice
This guideline summarizes preclinical data regarding DNA vaccines for Merkel cell carcinoma. The findings indicate that LTAgvax and STAgvax …
New DNA vaccines may help trigger a stronger immune response and slow tumor growth in models of Merkel cell carcinoma.
Frontiers Sep 4, 2026
PD-L1 expression shows subtype-specific prognostic value in skin neoplasms, meta-analysis finds
Dermatology Meta-analysis
PD-L1 expression shows subtype-specific prognostic value in skin neoplasms, meta-analysis finds Does a common cancer marker predict survival in skin cancers? It depends
A meta-analysis of 24 observational studies found PD-L1 expression was not significantly associated with overall survival (HR=0.89, 95% CI: …
A common skin cancer marker doesn't predict survival for everyone, but it does for specific types like Merkel cell carcinoma and melanoma.
Apr 6, 2026
FDA Approves Zynyz (retifanlimab-dlwr) for Metastatic Anal Canal Cancer and Merkel Cell Carcinoma
Oncology FDA Approval
FDA Approves Zynyz (retifanlimab-dlwr) for Metastatic Anal Canal Cancer and Merkel Cell Carcinoma FDA approves new drug Zynyz for two rare and aggressive types of cancer
The FDA has approved Zynyz, a PD-1 blocking antibody, for two indications: first-line treatment of inoperable locally recurrent or metastati…
FDA approves new drug Zynyz to treat two rare and aggressive cancers: advanced anal cancer and Merkel cell carcinoma.
FDA Apr 2, 2026

Questions about Merkel Cell Carcinoma

Is retifanlimab used as a first-line treatment for Merkel Cell Carcinoma?

Retifanlimab is approved as a treatment for metastatic or recurrent locally advanced Merkel cell carcinoma, but it is not the standard first-line treatment for non-metastatic cases.

Full answer →