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Migraine with or without aura

Part of Migraine

0 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for migraine with or without aura

11 trials tracked for migraine with or without aura: 9 in phase 3 or 4 and 9 with published results. The most-cited published study has 412 citations.

11Trials tracked
9Phase 3 & 4
0Recruiting
9With published results
Phase distribution
Phase 3 9 Phase 2 1 Other / NA 1
  1. Phase 3 Trial in Adult Subjects With Acute Migraines Completed · 412 cited
  2. Phase 3 Safety and Efficacy in Adult Subjects With Acute Migraines Completed · 411 cited
  3. Phase 3 Efficacy, Safety, and Tolerability of Multiple Dosing Regimens of Oral Atogepant (AGN-241689) in Episodic Migraine Prevention Completed · 230 cited
  4. Phase 3 Safety and Efficacy Study in Adult Subjects With Acute Migraines Completed · 51 cited
  5. Phase 3 Open Label Safety Study in Acute Treatment of Migraine Completed · 48 cited
  6. Phase 3 Efficacy, Safety, and Tolerability of Oral Ubrogepant in the Acute Treatment of Migraine Completed · 36 cited
Show 5 more trials
  1. Phase 3 Efficacy, Safety, and Tolerability Study of Oral Ubrogepant in the Acute Treatment of Migraine Completed · 36 cited
  2. Phase 3 An Extension Study to Evaluate the Long-Term Safety and Tolerability of Ubrogepant in the Treatment of Migraine Completed · 26 cited
  3. Phase 3 Three Doses of Lasmiditan (50 mg, 100 mg and 200 mg) Compared to Placebo in the Acute Treatment of Migraine Completed · 22 cited
  4. Phase 2 The Preventive Treatment of Migraine With Low-Dose Naltrexone and Acetaminophen Combination Completed
  5. N/A Cooling to Alleviate Migraine #3 Completed

Showing the 11 most-cited and recently-updated of 11 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Migraine with or without aura: what the trials found

Rimegepant has demonstrated statistically significant improvements in acute migraine symptoms at 2 hours post-dose. Specifically, trials showed significantly higher rates of pain freedom compared to placebo across multiple studies [2, 3, 5]. Additionally, Rimegepant was associated with significantly higher rates of freedom from the most bothersome symptom (MBS) and photophobia [2, 5]. One trial also reported a low incidence of liver enzyme elevations (AST/ALT > 3x ULN concurrent with total bilirubin > 2x ULN) during treatment 6.

Ubrogepant demonstrated statistically significant improvements in pain freedom at 2 hours post-dose compared to placebo across two trials [7, 8]. While results for the absence of the most bothersome symptom (MBS) were not statistically significant in one trial 7, they were significantly higher than placebo in another 8. Furthermore, Ubrogepant showed a statistically significant increase in pain relief at 2 hours post-dose compared to placebo 8.

Atogepant demonstrated a statistically significant reduction in mean monthly migraine days (migraine/probable migraine headache days) over a 12-week treatment period 4. It also resulted in a statistically significant reduction in mean monthly headache days during the same period 4. Lasmiditan 50 mg showed statistically significant results for both pain freedom and freedom from the most bothersome symptom at 2 hours post-dose 10.

Recent results — preliminary, needs further review

  • Mi-Helper did not show a statistically significant difference compared to placebo for pain freedom at 2 hours, freedom from most bothersome symptom (MBS) at 2 hours, or sustained pain freedom at 24 hours 1.

For the clinician treating this condition

  • Rimegepant provides statistically significant relief from pain, photophobia, and the most bothersome symptoms within 2 hours of administration [2, 3, 5].
  • Ubrogepant is associated with statistically significant pain freedom and increased pain relief at 2 hours post-dose [7, 8].
  • Atogepant significantly reduces the mean number of monthly migraine days over a 12-week period 4.
  • Lasmiditan 50 mg provides statistically significant relief from both pain and the most bothersome symptoms at 2 hours post-dose 10.

AI synthesis of 6 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
No published articles yet for this condition. Check back soon.

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