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Home › Conditions › neuropathy

Neuropathy

3 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for neuropathy

16 trials tracked for neuropathy: 3 in phase 3 or 4 and 2 with published results. The most-cited published study has 239 citations.

16Trials tracked
3Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 3 Phase 2 5 Phase 1 1 Other / NA 7
  1. Phase 3 Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy Completed · 239 cited
  2. Phase 3 S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, II, or IIIA Breast Cancer Undergoing Chemo Completed · 217 cited
  3. Phase 3 Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carboplatin in Patients With Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer Completed
  4. Phase 2 A Comparison of EpiCept™ NP-1 Topical Cream vs. Oral Gabapentin in Postherpetic Neuralgia (PHN) Completed
  5. Phase 2 The Efficacy and Safety of Clonidine Hydrochloride Topical Gel, vs Clonidine Hydrochloride Gel Comparator to Treat Painful Diabetic Neuropathy Completed
  6. Phase 2 Eribulin in Combination With Cyclophosphamide in Patients With Solid Tumor Malignancies Completed
Show 10 more trials
  1. Phase 2 Study of Clonidine Hydrochloride Topical Gel, 0.1% in the Treatment of Pain Associated With Diabetic Neuropathy Completed
  2. Phase 2 Therapeutic Interventions For Pain Induced By Vincristine Treatment For Childhood Acute Lymphoblastic Leukemia (ALL) Completed
  3. Phase 1 Study to Investigate the Effect of AB-101 in Breast Cancer Survivors Completed
  4. N/A Voxx Human Performance Technology Socks for Chemotherapy-Induced Peripheral Neuropathy Completed
  5. N/A Pregabalin in CIPN Completed
  6. N/A Electro-acupuncture for the Prevention of Taxane Induced Myalgias and Neuropathy Completed
  7. N/A A Wearable "Balance Booster" - Stepping Closer to the Market Completed
  8. N/A Tango for Neuropathy Among Breast Cancer Survivors Completed
  9. N/A Scrambler Therapy in the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy Completed
  10. N/A Effect of the Erchonia® EVRL OTC™ for the Relief of Diabetic Peripheral Neuropathy Foot Pain Completed

Showing the 16 most-cited and recently-updated of 16 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Neuropathy: what the trials found

Clinical data regarding chemotherapy-induced neuropathy and related interventions show varied outcomes. In studies evaluating calcium gluconate, research identified specific cumulative oxaliplatin doses (approximately 8.0 to 8.4) that could be administered without dose-limiting chronic neurotoxicity (p=0.89) 1.

Assessments of acetyl-L-carnitine hydrochloride for neuropathy did not show statistically significant differences compared to placebo in terms of FACT-Taxane Neurotoxicity Model-adjusted scores (p=0.17), FACT-Trial Outcome Index (TOI) functional status (p=0.92), or FACIT-fatigue scores (p=0.20) 2.

In trials evaluating Carboplatin, the assessment of Paclitaxel/Carboplatin induced peripheral neuropathy via EORTC QLQ-CIPN20 showed no significant difference between groups (p=0.21). Additionally, very low percentages of patients required chemotherapy delays or dose reductions due to peripheral neuropathy 3.

Recent results — preliminary, needs further review

  • Rhythmic Auditory Stimulation was evaluated for neuropathy symptoms and cancer-related fatigue; however, results showed mixed outcomes in symptom scores (6.68 vs 3.29) and BFI scores (8.56 vs 1.21) 10.

For the clinician treating this condition

  • Oxaliplatin administration can be managed with specific cumulative dose thresholds to avoid dose-limiting chronic neurotoxicity 1.
  • Acetyl-L-carnitine hydrochloride did not demonstrate statistically significant improvements in functional status or fatigue scores compared to placebo in the studied cohort 2.
  • Carboplatin/Paclitaxel regimens showed low rates of treatment delays or dose reductions specifically due to peripheral neuropathy 3.

AI synthesis of 4 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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