Left atrial appendage occlusion and NOACs reduce mortality compared with warfarin in atrial fibrillation
LAAO, low-dose NOACs beat warfarin for atrial fibrillation survival
A network meta-analysis compared left atrial appendage occlusion (LAAO), low-dose NOACs, standard-dose NOACs, and warfarin in non-valvular a…
For people with atrial fibrillation, warfarin may be the worst option for survival. New analysis finds LAAO and NOACs outperform it.
LAAC shows noninferior efficacy and reduced bleeding versus NOACs in non-valvular AF
New data shows left atrial appendage closure offers bleeding safety for some adults with atrial fibrillation
This meta-analysis of RCTs in adults with non-valvular AF found percutaneous left atrial appendage closure (LAAC) achieved noninferiority fo…
A large review of trials found that closing the heart appendage reduced bleeding compared to blood thinners. However, stroke risk trends wer…
Sex differences in outcomes after stroke in NVAF with ASCVD: a post hoc analysis
Women and Men With AFib and Clogged Arteries Share Same Stroke Risk
This post hoc analysis of an RCT included 222 patients with recent ischemic stroke or TIA, NVAF, and ASCVD. No significant sex differences w…
Women and men with AFib and clogged arteries face similar risks for stroke, heart attack, and bleeding over two years.
Machine learning models predict stroke risk in low-risk non-valvular atrial fibrillation patients using cardiac biomarkers
New ML models predict stroke risk in low-risk atrial fibrillation patients
This single-center, retrospective cohort study evaluated machine-learning models for stroke risk prediction in 82 NVAF-related stroke cases …
A new study shows machine learning models using heart markers can better predict stroke risk in patients with low-risk atrial fibrillation.
FDA Approves Xarelto (rivaroxaban) for multiple indications including stroke prevention in nonvalvular atrial fibrillation and treatment of VTE
FDA approves a new blood thinner called Xarelto for several heart and clot conditions
The FDA approved rivaroxaban (Xarelto), a factor Xa inhibitor, for multiple indications including reducing stroke risk in nonvalvular atrial…
FDA approves new blood thinner Xarelto to prevent dangerous clots in heart conditions, deep vein issues, and after major surgeries.
Research across Atrial Fibrillation
Related studies from across the Atrial Fibrillation family.
Higher Triglyceride-glucose index levels are associated with increased risk of Atrial Fibrillation
Higher Triglyceride-Glucose Index Linked to Increased Risk of Atrial Fibrillation
This meta-analysis of 25,376 individuals found significantly higher TyG index levels in patients with Atrial Fibrillation compared to those …
A high triglyceride-glucose index may serve as a potential marker for identifying people at risk for atrial fibrillation and related heart c…
Sarcopenia linked to 2.16-fold higher odds of atrial fibrillation in meta-analysis
Muscle loss linked to higher risk of irregular heartbeats
A meta-analysis of over 3 million patients found sarcopenia associated with significantly higher odds of atrial fibrillation (OR 2.16; 95% C…
A large study involving over 3 million people found that muscle loss, known as sarcopenia, is linked to a higher risk of developing atrial f…
Antazoline May Beat Propafenone and Amiodarone for AF Conversion
Antazoline shows better results for atrial fibrillation heart rhythms
A meta-analysis suggests antazoline is more effective than propafenone or amiodarone for converting atrial fibrillation to sinus rhythm, wit…
A new review suggests antazoline may be more effective than common medications at restoring normal heart rhythms for patients with atrial fi…
Catheter ablation reduces atrial fibrillation recurrence compared to anti-arrhythmic drugs in paroxysmal and persistent cases
Catheter Ablation Shows Lower Recurrence Rates for Atrial Fibrillation
This systematic review and meta-analysis of randomized controlled trials compares catheter ablation to anti-arrhythmic drugs (AAD) for manag…
A review of clinical trials suggests catheter ablation may lead to lower heart rhythm recurrence rates compared to anti-arrhythmic drugs.
Cardiac rehabilitation reduces atrial fibrillation recurrence (RR 0.77) and improves exercise capacity in patients
Cardiac Rehabilitation May Reduce Recurrence of Atrial Fibrillation
This meta-analysis of randomized controlled trials involving 1550 patients found that cardiac rehabilitation significantly reduced overall a…
A review of clinical trials suggests that cardiac rehabilitation can lower the risk of atrial fibrillation returning and improve exercise ca…
Pulsed field ablation reduces procedure time compared to very high-power short-duration ablation in atrial fibrillation
Pulsed field ablation speeds up heart surgery for atrial fibrillation
This meta-analysis of 11 observational studies evaluated pulsed field ablation (PFA) against very high-power short-duration ablation (vHPSD)…
A newer technique called pulsed field ablation can significantly shorten procedure times for patients undergoing heart surgery to treat irre…
Rhythm control for postcardiac surgery atrial fibrillation shows higher conversion rates but increased risks
Rhythm Control Shows Higher Risks for Post-Surgery Heart Patients
Researchers evaluated the clinical impact of rhythm control versus rate control in patients with atrial fibrillation following cardiac surge…
Aggressive heart rhythm treatments may increase the risk of side effects like low blood pressure in patients following heart surgery.
Inadequate sleep duration is associated with higher risk of atrial flutter recurrence after ablation
Short or long sleep may increase risk of heart rhythm issues
This multicentre randomized controlled trial of 720 patients undergoing catheter ablation for atrial fibrillation found no significant assoc…
Patients with atrial fibrillation who get less than 6 hours or more than 8 hours of sleep face a higher risk of specific heart rhythm recurr…
Left atrial appendage electrical isolation combined with pulmonary vein isolation reduces recurrent atrial arrhythmia
Adding Electrical Isolation Reduces Recurrent Arrhythmia in Atrial Fibrillation
This meta-analysis evaluated the addition of left atrial appendage electrical isolation to standard pulmonary vein isolation for patients wi…
A new analysis shows that adding electrical isolation to standard procedures can significantly lower the risk of recurring heart rhythm issu…
Patients with cardiovascular diseases show measurable prevalence of active cancer across multiple conditions
Heart disease patients show measurable risk of developing various cancers
This systematic review and meta-analysis analyzed 4,759,695 patients to determine the prevalence of active cancer in individuals with variou…
New data shows that people with heart conditions like stroke or heart failure have a measurable rate of active cancer cases.
Macrophage migration inhibitory factor serves as a potential biomarker and therapeutic target for atrial fibrillation
Protein levels may predict heart failure and stroke risks
This systematic review synthesizes evidence regarding macrophage migration inhibitory factor (MIF) in the context of atrial fibrillation and…
A specific protein called MIF is linked to heart damage and can help doctors predict serious complications like stroke or heart failure.
Electrical cardioversion and catheter ablation are safe and effective for arrhythmias in pregnant women
Catheter Ablation and Cardioversion Show Success for Pregnant Women
This narrative review synthesizes evidence regarding electrical cardioversion and catheter ablation for managing arrhythmias during pregnanc…
New data shows that both electrical cardioversion and catheter ablation are effective ways to treat heart rhythm issues in pregnant patients…
Questions about Nonvalvular Atrial Fibrillation
Is left atrial appendage occlusion better than warfarin for Nonvalvular Atrial Fibrillation mortality?
Yes, left atrial appendage occlusion (LAAO) is associated with lower all-cause mortality compared to warfarin in patients with nonvalvular atrial fibrillation, based on network meta-analyses.
Full answer →Are there sex differences in stroke outcomes for people with Nonvalvular Atrial Fibrillation?
Yes, sex differences exist: women with NVAF-related stroke tend to have worse short-term outcomes, but after adjusting for age and other factors, their long-term mortality risk may be lower.
Full answer →Does left atrial appendage closure cause less bleeding than NOACs for Nonvalvular Atrial Fibrillation?
Yes, left atrial appendage closure (LAAC) causes significantly less non-procedural bleeding than NOACs in patients with nonvalvular atrial fibrillation, based on recent trials.
Full answer →Is Xarelto approved to prevent strokes in patients with Nonvalvular Atrial Fibrillation?
Yes, Xarelto (rivaroxaban) is FDA-approved for stroke prevention in nonvalvular atrial fibrillation, based on the ROCKET-AF trial showing it is noninferior to warfarin with a favorable benefit-risk profile.
Full answer →