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13 trials tracked for Opioid-induced constipation: 7 in phase 3 or 4 and 6 with published results. The most-cited published study has 510 citations.
Showing the 13 most-cited and recently-updated of 13 trials. Browse the full registry →
Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.
Naldemedine has demonstrated significant efficacy in improving spontaneous bowel movements (SBM) and overall constipation symptoms. Trials showed a statistically significant increase in the number of SBMs per week from baseline to both Week 1 and the final two weeks of treatment [4, 6]. Specifically, Naldemedine was associated with an increase of approximately 3.42 to 3.88 SBMs per week compared to placebo [4, 5, 6], while also significantly reducing scores on patient assessment scales for constipation symptoms 5.
Methylnaltrexone is associated with rapid laxation responses and increased bowel movement frequency. Evidence indicates a high proportion of subjects achieved rescue-free laxation within 4 hours of dosing 2 and significant improvements in the number of laxations per week 3. Furthermore, methylnaltrexone demonstrated a statistically significant increase in the percentage of participants achieving a laxation response within both 2 and 4 hours of the first dose compared to placebo 8.
While multiple studies evaluated methylnaltrexone for OIC, results regarding specific responder rates over 4 weeks showed no statistically significant difference between treatment arms 7. Additionally, patient preference data suggests that while certain medications like Movantik and PEG 3350 were compared in terms of Bowel Function Index (BFI) scores, there was no statistically significant difference in patient reported preference between the two treatments 1.
AI synthesis of 8 cited trials, updated Aug 27, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.