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Home › Conditions › Otitis Media With Effusion

Otitis Media With Effusion

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials for Otitis Media With Effusion

8 trials tracked for Otitis Media With Effusion: 4 in phase 3 or 4 and 2 with published results. The most-cited published study has 21 citations.

8Trials tracked
4Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 3 4 Other / NA 4
  1. Phase 3 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement Completed · 21 cited
  2. Phase 3 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement Completed · 21 cited
  3. Phase 3 Evaluation of the Tympanostomy Tube Delivery System Completed
  4. Phase 3 Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays Completed
  5. N/A A Clinical Trial of Proton Pump Inhibitors to Treat Children With Chronic Otitis Media With Effusion Completed
  6. N/A Wide Frequency Band Test of Hearing in Veterans Completed
Show 2 more trials
  1. N/A Clinical Study of the Tympanostomy Tube Delivery System Completed
  2. N/A Osteopathic Otitis Media Research Study Completed

Showing the 8 most-cited and recently-updated of 8 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found For clinicians

Otitis Media With Effusion: what the trials found

Clinical trials have evaluated OTO-201 for the treatment of Otitis Media with Effusion. In Phase 3 studies, the treatment failure rates for OTO-201 were reported at 21.3% and 24.6% in two separate trials [1, 2].

The use of tympanostomy tubes has been evaluated in Phase 3 trials for this condition 3. Additionally, triamcinolone acetonide nasal spray was evaluated; however, results for complete normalization of abnormal tympanometry did not reach statistical significance, with p-values of 0.18 and 0.24 respectively 4.

Recent results — preliminary, needs further review

  • Osteopathic manipulative medicine (OMM) showed a statistically significant change in middle ear effusion over four weeks following acute otitis media (p=0.02), though changes immediately following OMM at specific study visits did not reach statistical significance (p=0.32 and p=0.31) 6.
  • The Acclarent Tympanostomy Tube Delivery System 7 and lansoprazole 8 have been investigated but are not yet corroborated.

For the clinician treating this condition

  • OTO-201 demonstrated treatment failure rates between 21.3% and 24.6% in Phase 3 trials [1, 2].
  • Triamcinolone acetonide nasal spray did not show a statistically significant improvement in the normalization of abnormal tympanometry 4.

AI synthesis of 5 cited trials, updated Sep 14, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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This meta-analysis of 582 patients indicates that radiotherapy for nasopharyngeal carcinoma is associated with a significant increase in oti…
Patients undergoing radiotherapy for nasopharyngeal cancer face a higher risk of developing fluid in the middle ear, a common side effect of…
Sep 12, 2026